pI: 6.4784 |
Length (AA): 932 |
MW (Da): 104035 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 123 | 3mkq (A) | 587 | 709 | 7.00 | 0.000062 | 0.02 | 0.195874 | -0.2 |
8 | 123 | 5i9d (A) | 68 | 184 | 11.00 | 0.0000094 | 0.26 | 0.194364 | -0.32 |
398 | 541 | 1elr (A) | 223 | 349 | 20.00 | 0 | 0.84 | 0.323006 | -0.38 |
442 | 737 | 1b89 (A) | 1186 | 1468 | 16.00 | 0 | 1 | 0.164097 | 1.4 |
487 | 614 | 3q49 (B) | 24 | 155 | 18.00 | 0 | 0.34 | 0.296839 | -0.32 |
863 | 930 | 5a01 (A) | 367 | 435 | 15.00 | 0.3 | 0.08 | 0.394861 | -1.92 |
867 | 910 | 2kck (A) | 21 | 64 | 16.00 | 0.58 | 0.06 | 0.30911 | -1.14 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst. | Gregory Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | ME49 Bradyzoite. | Sibley/Greg |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_130315)
Species | Accession | Gene Product |
---|---|---|
Caenorhabditis elegans | CELE_C27A7.4 | Protein CHE-11 |
Drosophila melanogaster | Dmel_CG11838 | reduced mechanoreceptor potential A |
Echinococcus granulosus | EgrG_000374900 | intraflagellar transport protein 140 |
Echinococcus multilocularis | EmuJ_000374900 | intraflagellar transport protein 140 |
Homo sapiens | ENSG00000187535 | intraflagellar transport 140 |
Leishmania braziliensis | LbrM.32.0380 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_320320.1 | intraflagellar transport protein 140, putative |
Leishmania infantum | LinJ.32.0320 | hypothetical protein, conserved |
Leishmania major | LmjF.32.0310 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.31.0310 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_15585 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06991 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12707 | hypothetical protein |
Mus musculus | ENSMUSG00000024169 | intraflagellar transport 140 |
Neospora caninum | NCLIV_052170 | hypothetical protein, conserved |
Onchocerca volvulus | OVOC10121 |
|
Onchocerca volvulus | OVOC10126 |
|
Schistosoma japonicum | Sjp_0108670 | IPR008262,Lipase, active site;IPR001680,WD-40 repeat;IPR011046,WD40-like,domain-containing |
Schistosoma japonicum | Sjp_0101550 | Conserved hypothetical protein |
Schistosoma mansoni | Smp_163250 | hypothetical protein |
Schmidtea mediterranea | mk4.027327.00 | |
Schmidtea mediterranea | mk4.013795.00 | |
Schmidtea mediterranea | mk4.004640.01 | Intraflagellar transport protein 140 homolog |
Schmidtea mediterranea | mk4.004640.00 | Intraflagellar transport protein 140 homolog |
Trypanosoma brucei gambiense | Tbg972.10.17590 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.14470 | intraflagellar transport protein 140 |
Trypanosoma congolense | TcIL3000_10_12370 | intraflagellar transport protein 140, putative |
Trypanosoma cruzi | TcCLB.506215.19 | intraflagellar transport protein 140, putative |
Toxoplasma gondii | TGME49_215195 | tetratricopeptide repeat-containing protein |
Toxoplasma gondii | TGME49_215185 | hypothetical protein |
Trichomonas vaginalis | TVAG_083840 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_404040 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_003730 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_483890 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_310210 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14470 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14470 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14470 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.14470 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_215195 this record | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_215185 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.