Detailed view for TcCLB.510879.50

Basic information

TDR Targets ID: 34059
Trypanosoma cruzi, regulatory subunit of protein kinase a-like protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.5687 | Length (AA): 558 | MW (Da): 62801 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
207 387 1q3e (A) 448 622 16.00 0 0.6 0.51 -0.25
256 535 1cx4 (A) 131 411 19.00 0 1 0.5 -0.28
270 384 1pf0 (A) 228 335 19.00 0.0000000000031 0.98 0.49 -0.74
19 149 2lem (A) 82 206 18.00 0.24 0.07 0.399867 -0.27
217 521 4din (B) 53 374 27.00 0 1 0.798995 0.7
233 521 2qcs (B) 90 374 31.00 0 1 0.905721 -0.17
237 513 3tnp (B) 110 392 25.00 0 1 0.711816 0.57
260 532 1cx4 (A) 135 408 27.00 0 1 0.863047 -0.33
260 383 5c8w (A) 151 269 21.00 0 1 0.580622 -1.15
271 362 4off (A) 412 498 36.00 0.0000047 1 0.573675 -0.08
385 513 5jix (A) 271 400 28.00 0 1 0.669783 -0.91
490 551 3kcc (B) 92 153 19.00 0.0054 0.02 0.360211 -0.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_166709)

Species Accession Gene Product
Leishmania braziliensis LbrM.20.2440   regulatory subunit of protein kinase a-like protein
Leishmania donovani LdBPK_342680.1   regulatory subunit of protein kinase a-like protein
Leishmania infantum LinJ.34.2680   regulatory subunit of protein kinase a-like protein
Leishmania major LmjF.34.2820   regulatory subunit of protein kinase a-like protein
Leishmania mexicana LmxM.33.2820   regulatory subunit of protein kinase a-like protein
Trypanosoma cruzi TcCLB.510879.50   regulatory subunit of protein kinase a-like protein, putative
Trypanosoma cruzi TcCLB.504013.60   regulatory subunit of protein kinase a-like protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.510879.50 (Trypanosoma cruzi), regulatory subunit of protein kinase a-like protein, putative
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