Detailed view for PF3D7_0308200

Basic information

TDR Targets ID: 3582
Plasmodium falciparum, T-complex protein 1 subunit eta
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.3037 | Length (AA): 539 | MW (Da): 59577 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00118   TCP-1/cpn60 chaperonin family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005832   chaperonin-containing T-complex  
GO:0051082   unfolded protein binding  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0044267   cellular protein metabolic process  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 528 1q3q (A) 9 526 35.00 0 1 1.35 -1.17
18 524 1a6d (A) 17 519 36.00 0 1 1.5 -1.41
9 527 4b2t (H) 6 523 58.00 0 1 1.57339 -0.25
227 366 1ass (A) 12 151 32.00 0.000000027 1 0.76534 -0.98

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 48 hs, gametocyte, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127782)

Species Accession Gene Product
Arabidopsis thaliana AT3G11830   TCP-1/cpn60 chaperonin family protein
Babesia bovis BBOV_IV006970   T-complex protein 1 eta subunit, putative
Brugia malayi Bm1_22985   T-complex protein 1, eta subunit
Candida albicans CaO19.3206   similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Candida albicans CaO19.10718   similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Caenorhabditis elegans CELE_T10B5.5   Protein CCT-7, isoform B
Cryptosporidium hominis Chro.40440   T-complex protein 1
Cryptosporidium parvum cgd4_3860   TCP-1/cpn60 chaperonin family, T-complex protein subunit 7 (eta)
Dictyostelium discoideum DDB_G0291225   chaperonin containing TCP1 eta subunit
Drosophila melanogaster Dmel_CG8351   CG8351 gene product from transcript CG8351-RA
Echinococcus granulosus EgrG_000576700   T complex protein 1 subunit eta
Entamoeba histolytica EHI_083260   T-complex protein 1 subunit eta, putative
Entamoeba histolytica EHI_044940   T-complex protein 1 subunit eta, putative
Echinococcus multilocularis EmuJ_000576700   T complex protein 1 subunit eta
Giardia lamblia GL50803_16124   TCP-1 chaperonin subunit eta
Homo sapiens ENSG00000135624   chaperonin containing TCP1, subunit 7 (eta)
Leishmania braziliensis LbrM.34.3840   T-complex protein 1, eta subunit, putative
Leishmania donovani LdBPK_353900.1   T-complex protein 1, eta subunit, putative
Leishmania infantum LinJ.35.3900   T-complex protein 1, eta subunit, putative
Leishmania major LmjF.35.3860   T-complex protein 1, eta subunit, putative
Leishmania mexicana LmxM.34.3860   T-complex protein 1, eta subunit, putative
Loa Loa (eye worm) LOAG_00662   T-complex protein 1
Mus musculus ENSMUSG00000030007   chaperonin containing Tcp1, subunit 7 (eta)
Neospora caninum NCLIV_006510   TCP-1/cpn60 family chaperonin, putative
Oryza sativa 4341893   Os06g0687700
Plasmodium berghei PBANKA_0406500   T-complex protein 1 subunit eta, putative
Plasmodium falciparum PF3D7_0308200   T-complex protein 1 subunit eta
Plasmodium knowlesi PKNH_0834500   T-complex protein 1 subunit eta, putative
Plasmodium vivax PVX_119530   T-complex protein 1 subunit eta, putative
Plasmodium yoelii PY01933   chaperonin, 60 kDa
Saccharomyces cerevisiae YJL111W   Cct7p
Schistosoma japonicum Sjp_0211340   ko:K09499 T-complex protein 1 subunit eta, putative
Schistosoma mansoni Smp_149900   chaperonin containing t-complex protein 1 eta subunit tcph
Schmidtea mediterranea mk4.015406.00  
Trypanosoma brucei gambiense Tbg972.9.6730   T-complex protein 1, eta subunit, putative,t- complex protein 1 (eta subunit), putative
Trypanosoma brucei Tb927.9.11270   t- complex protein 1 (eta subunit), putative
Trypanosoma congolense TcIL3000_9_4650   t- complex protein 1 (eta subunit), putative
Trypanosoma cruzi TcCLB.508461.410   T-complex protein 1, eta subunit, putative
Toxoplasma gondii TGME49_297500   T-complex protein 1 eta subunit
Theileria parva TP03_0210   T-complex protein 1, eta subunit, putative
Trichomonas vaginalis TVAG_182370   chaperonin containing t-complex protein 1, gamma subunit, tcpg, putative
Trichomonas vaginalis TVAG_398480   chaperonin-60kD, ch60, putative

Essentiality

PF3D7_0308200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.2570 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.2570 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.2570 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.2570 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T10B5.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_T10B5.5 Caenorhabditis elegans larval arrest wormbase
CELE_T10B5.5 Caenorhabditis elegans slow growth wormbase
CELE_T10B5.5 Caenorhabditis elegans sterile wormbase
YJL111W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0406500 Plasmodium berghei Essential plasmo
TGME49_297500 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaaca fascicularis T-complex protein 1 subunit beta 535 aa 34.9% 542 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0308200 (Plasmodium falciparum), T-complex protein 1 subunit eta
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