Detailed view for BBOV_IV011370

Basic information

TDR Targets ID: 359246
Babesia bovis, PK4 protein kinase

Source Database / ID: 

pI: 6.3347 | Length (AA): 1033 | MW (Da): 116319 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
146 224 2yms (C) 231 318 22.00 0 0.3 0.0661763 -0.09
545 616 2w1z (A) 213 282 20.00 0 0.15 0.2094 -0.13
575 616 3uiu (A) 257 296 37.00 0 0.34 0.324358 0.11
579 610 4x7k (A) 587 618 44.00 0 0.35 0.338678 1.08
747 1031 5da3 (A) 187 421 24.00 0 1 0.312595 0.09
819 913 2a19 (C) 333 466 57.00 0.000015 0.84 0.178865 1.26
854 911 1cm8 (A) 116 174 52.00 0.0053 1 0.578047 -0.33
864 918 3e3p (A) 123 180 40.00 0.7 0.7 0.420143 0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_140247)

Species Accession Gene Product
Babesia bovis BBOV_IV011370   PK4 protein kinase
Cryptosporidium hominis Chro.10109   protein kinase domain
Cryptosporidium parvum cgd1_890   protein kinase domain
Dictyostelium discoideum DDB_G0276043   GCN2 subfamily protein kinase
Dictyostelium discoideum DDB_G0268642   PEK family protein kinase
Dictyostelium discoideum DDB_G0295843   hypothetical protein
Plasmodium berghei PBANKA_1126900   eukaryotic translation initiation factor 2-alpha kinase
Plasmodium falciparum PF3D7_0628200   eukaryotic translation initiation factor 2-alpha kinase
Plasmodium knowlesi PKNH_1121600   eukaryotic translation initiation factor 2-alpha kinase, putative
Plasmodium vivax PVX_114512   eukaryotic translation initiation factor 2-alpha kinase, putative
Plasmodium yoelii PY05545   Protein kinase domain, putative
Theileria parva TP01_1167   protein kinase, putative

Essentiality

BBOV_IV011370 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1126900 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Casein kinase I isoform alpha 125 aa 28.2% 124 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier BBOV_IV011370 (Babesia bovis), PK4 protein kinase
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