Detailed view for BBOV_IV007730

Basic information

TDR Targets ID: 361145
Babesia bovis, cysteine protease 2
Source Database / ID: 

pI: 7.3085 | Length (AA): 445 | MW (Da): 49328 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00112   Papain family cysteine protease
PF08246   Cathepsin propeptide inhibitor domain (I29)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
123 444 3qt4 (A) 7 310 28.00 0 1 0.930296 0.21
126 422 1xkg (A) 8 281 31.00 0 1 0.847516 0.61
126 188 3f75 (P) 117 178 23.00 0 0.09 0.346973 0.03
238 445 3bcn (A) 3 203 46.00 0 1 0.880516 0.08
238 445 1yal (A) 3 214 44.00 0 1 0.989516 -0.81
238 444 1gec (E) 3 213 43.00 0 1 1.01727 -0.81
240 437 1iwd (A) 5 205 41.00 0 1 0.902044 -0.36
240 437 2fo5 (A) 8 215 47.00 0 1 0.929044 -0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129645)

Species Accession Gene Product
Babesia bovis BBOV_III010070   papain family cysteine protease containing protein
Babesia bovis BBOV_IV007730   cysteine protease 2
Mus musculus ENSMUSG00000028111   cathepsin K
Theileria parva TP03_0284   cysteine proteinase, putative
Theileria parva TP03_0280   cysteine proteinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus cathepsin K Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major cathepsin L-like protease 348 aa 32.2% 326 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 32.8% 326 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 32.5% 326 aa Compounds References
Dermatophagoides pteronyssinus Peptidase 1 320 aa 27.2% 305 aa Compounds References
Oryctolagus cuniculus Cathepsin K 329 aa 30.3% 343 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 32.8% 326 aa Compounds References
Rattus norvegicus Cathepsin K 329 aa 31.0% 326 aa Compounds References
Capra hircus Cathepsin H 335 aa 31.0% 339 aa Compounds References
Leishmania donovani Cysteine protease 394 aa 31.3% 326 aa Compounds References
Canis familiaris Cathepsin K 330 aa 30.0% 343 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 32.5% 326 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier BBOV_IV007730 (Babesia bovis), cysteine protease 2
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