Detailed view for Chro.60564

Basic information

TDR Targets ID: 364483
Cryptosporidium hominis, transporter
Source Database / ID: 

pI: 5.9743 | Length (AA): 446 | MW (Da): 49734 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08627   CRT-like, chloroquine-resistance transporter-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0015238   drug transporter activity  
GO:0006855   multidrug transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133154)

Species Accession Gene Product
Arabidopsis thaliana AT4G24460   CRT (chloroquine-resistance transporter)-like transporter 2
Arabidopsis thaliana AT5G12170   CRT (chloroquine-resistance transporter)-like transporter 3
Arabidopsis thaliana AT5G19380   CRT (chloroquine-resistance transporter)-like transporter 1
Babesia bovis BBOV_III003790   conserved hypothetical protein
Cryptosporidium hominis Chro.60564   transporter
Cryptosporidium parvum cgd6_4890   transporter protein with conserved Zn ribbon C11C7CxxC
Dictyostelium discoideum DDB_G0277321   chloroquine resistance transporter-like protein
Dictyostelium discoideum DDB_G0270204   chloroquine resistance transporter-like protein
Dictyostelium discoideum DDB_G0276943   chloroquine resistance transporter-like protein
Neospora caninum NCLIV_057130   hypothetical protein, conserved
Oryza sativa 4325409   Os01g0955700
Oryza sativa 4352325   Os12g0511300
Plasmodium berghei PBANKA_1219500   chloroquine resistance transporter, putative
Plasmodium falciparum PF3D7_0709000   chloroquine resistance transporter
Plasmodium knowlesi PKNH_0107600   chloroquine resistance transporter, putative
Plasmodium vivax PVX_087980   chloroquine resistance transporter, putative
Plasmodium yoelii PY05061   putative transporter protein CG10
Toxoplasma gondii TGME49_313930   transmembrane protein
Theileria parva TP02_0224   hypothetical protein

Essentiality

Chro.60564 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1219500 Plasmodium berghei Essential plasmo
TGME49_313930 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum chloroquine resistance transporter Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Chro.60564 (Cryptosporidium hominis), transporter
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