Detailed view for cgd7_1840

Basic information

TDR Targets ID: 376123
Cryptosporidium parvum, calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands
Source Database / ID: 

pI: 5.1999 | Length (AA): 676 | MW (Da): 77553 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00686   Starch binding domain
PF13202   EF hand
PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:2001070   GO:starch binding  

GO:0030246   carbohydrate binding  
GO:0005524   ATP binding  
GO:0005509   calcium ion binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 101 1vem (A) 423 508 22.00 0 0.45 0.225291 -0.31
59 483 3uto (A) 6 442 28.00 0 1 0.859398 0.37
187 648 3q5i (A) 38 517 37.00 0 1 1.15343 -0.7
190 465 2qg5 (A) 12 287 96.00 0 1 1.48348 -1.03
194 647 3hx4 (A) 39 503 37.00 0 1 1.1523 -0.83
194 651 3lij (A) 50 515 38.00 0 1 1.17921 -0.84
502 564 2pmy (A) 6 67 23.00 0.00034 0.86 0.532895 -1.56
581 645 2ro9 (A) 86 145 47.00 0 0.97 0.505954 -0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2QG5:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3F3Z:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_170347)

Species Accession Gene Product
Cryptosporidium hominis Chro.70214   calmodulin-domain protein kinase 2
Cryptosporidium parvum cgd7_1840   calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands
Neospora caninum NCLIV_047220   Calcium-dependent protein kinase, related
Toxoplasma gondii TGME49_225490   calcium-dependent protein kinase CDPK2

Essentiality

cgd7_1840 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_225490 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 23.4% 337 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 27.5% 306 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 27.4% 157 aa Compounds References
Bos taurus Calmodulin 149 aa 30.5% 151 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.9% 294 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 29.7% 303 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 27.3% 286 aa Compounds References
Triticum aestivum Calcium dependent protein kinase 548 aa 34.4% 485 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 29.1% 309 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 27.4% 303 aa Compounds References
Patiria pectinifera Cdc2 300 aa 24.6% 293 aa Compounds References
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 528 aa 35.9% 468 aa Compounds References
Zea mays CaM kinase I alpha 492 aa 35.9% 463 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier cgd7_1840 (Cryptosporidium parvum), calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands
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