pI: 8.4949 |
Length (AA): 492 |
MW (Da): 52019 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 489 | 3tsb (B) | 0 | 476 | 48.00 | 0 | 1 | 1.30657 | 0.65 |
10 | 489 | 1zfj (A) | 9 | 481 | 47.00 | 0 | 1 | 1.47981 | 0.04 |
10 | 490 | 5uwx (A) | 5 | 472 | 53.00 | 0 | 1 | 1.01684 | 1.29 |
101 | 215 | 3oco (A) | 233 | 342 | 18.00 | 0 | 0.99 | 0.50544 | -0.68 |
163 | 489 | 5upy (A) | 17 | 476 | 42.00 | 0 | 1 | 1.04433 | 0.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126887)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G16350 | inosine-5'-monophosphate dehydrogenase 2 |
Arabidopsis thaliana | AT1G79470 | inosine-5'-monophosphate dehydrogenase |
Babesia bovis | BBOV_IV006900 | inosine-5'-monophosphate dehydrogenase, putative |
Brugia malayi | Bm1_31240 | inosine-5'-monophosphate dehydrogenase family protein |
Candida albicans | CaO19.7689 | guanosine nucleotide biosynthesis |
Candida albicans | CaO19.18 | guanosine nucleotide biosynthesis |
Candida albicans | CaO19.19 | N terminus of Inosine-5'-monophosphate dehydrogenase |
Candida albicans | CaO19.7690 | N terminus of Inosine-5'-monophosphate dehydrogenase |
Caenorhabditis elegans | CELE_T22D1.3 | Protein T22D1.3, isoform B |
Cryptosporidium hominis | Chro.60012 | inosine-5-monophosphate dehydrogenase |
Cryptosporidium parvum | cgd6_20 | inosine-5-monophosphate dehydrogenase |
Dictyostelium discoideum | DDB_G0283701 | IMP dehydrogenase |
Drosophila melanogaster | Dmel_CG1799 | raspberry |
Escherichia coli | b2508 | IMP dehydrogenase |
Echinococcus granulosus | EgrG_000120200 | inosine 5' monophosphate dehydrogenase 2 |
Echinococcus multilocularis | EmuJ_000120200 | inosine 5' monophosphate dehydrogenase 2 |
Homo sapiens | ENSG00000106348 | IMP (inosine 5'-monophosphate) dehydrogenase 1 |
Homo sapiens | ENSG00000178035 | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
Leishmania braziliensis | LbrM.19.1820 | inosine-5-monophosphate dehydrogenase |
Leishmania braziliensis | LbrM.17.0790 | guanosine monophosphate reductase, putative |
Leishmania donovani | LdBPK_191590.1 | inosine-5'-monophosphate dehydrogenase |
Leishmania donovani | LdBPK_170870.1 | GMP reductase |
Leishmania infantum | LinJ.19.1590 | inosine-5-monophosphate dehydrogenase |
Leishmania infantum | LinJ.17.0870 | guanosine monophosphate reductase, putative |
Leishmania major | LmjF.17.0725 | guanosine monophosphate reductase |
Leishmania major | LmjF.19.1560 | inosine-5-monophosphate dehydrogenase |
Leishmania mexicana | LmxM.17.0725 | guanosine monophosphate reductase |
Leishmania mexicana | LmxM.19.1560 | inosine-5-monophosphate dehydrogenase |
Loa Loa (eye worm) | LOAG_00767 | IMP dehydrogenase 1 |
Mycobacterium leprae | ML0388 | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena |
Mycobacterium leprae | ML0387 | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) |
Mus musculus | ENSMUSG00000062867 | inosine 5'-phosphate dehydrogenase 2 |
Mus musculus | 100042069 | predicted gene 15210 |
Mus musculus | ENSMUSG00000003500 | inosine 5'-phosphate dehydrogenase 1 |
Mycobacterium tuberculosis | Rv3411c | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase |
Mycobacterium tuberculosis | Rv3410c | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase |
Mycobacterium ulcerans | MUL_0901 | inosine 5-monophosphate dehydrogenase |
Mycobacterium ulcerans | MUL_0900 | inosine 5'-monophosphate dehydrogenase |
Neospora caninum | NCLIV_032920 | hypothetical protein |
Oryza sativa | 4334308 | Os03g0780500 |
Plasmodium berghei | PBANKA_0821700 | inosine-5'-monophosphate dehydrogenase, putative |
Plasmodium falciparum | PF3D7_0920800 | inosine-5'-monophosphate dehydrogenase |
Plasmodium knowlesi | PKNH_0718800 | inosine-5'-monophosphate dehydrogenase, putative |
Plasmodium vivax | PVX_099455 | inosine-5'-monophosphate dehydrogenase, putative |
Plasmodium yoelii | PY03601 | inosine-5'-monophosphate dehydrogenase |
Saccharomyces cerevisiae | YHR216W | IMP dehydrogenase IMD2 |
Saccharomyces cerevisiae | YML056C | IMP dehydrogenase IMD4 |
Saccharomyces cerevisiae | YLR432W | IMP dehydrogenase IMD3 |
Schistosoma japonicum | Sjp_0061360 | ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative |
Schistosoma mansoni | Smp_012930 | inosine-5-monophosphate dehydrogenase |
Schmidtea mediterranea | mk4.000519.05 | Inosine-5'-monophosphate dehydrogenase |
Schmidtea mediterranea | mk4.000519.04 | |
Schmidtea mediterranea | mk4.037673.02 | Inosine-5'-monophosphate dehydrogenase |
Trypanosoma brucei gambiense | Tbg972.10.19740 | inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative |
Trypanosoma brucei gambiense | Tbg972.5.2930 | inosine-5-monophosphate dehydrogenase, putative |
Trypanosoma brucei | Tb927.10.16120 | inosine-5'-monophosphate dehydrogenase |
Trypanosoma brucei | Tb927.5.2080 | GMP reductase |
Trypanosoma congolense | TcIL3000_5_1940 | GMP reductase |
Trypanosoma cruzi | TcCLB.508909.20 | GMP reductase |
Trypanosoma cruzi | TcCLB.506519.130 | GMP reductase |
Trypanosoma cruzi | TcCLB.507211.40 | inosine-5'-monophosphate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.511351.9 | inosine-5'-monophosphate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.511301.110 | inosine-5'-monophosphate dehydrogenase, putative |
Toxoplasma gondii | TGME49_233110 | IMP dehydrogenas |
Theileria parva | TP03_0220 | Inosine-5'-monophosphate dehydrogenase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0527 | IMP dehydrogenase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3472 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.5.2080 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.2080 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.2080 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.2080 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.16120 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.16120 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.16120 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.16120 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2508 | Escherichia coli | essential | goodall |
PBANKA_0821700 | Plasmodium berghei | Essential | plasmo |
TGME49_233110 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | inosine 5'-phosphate dehydrogenase 2 | Compounds | References |
Bacillus anthracis | Inosine-5'-monophosphate dehydrogenase | Compounds | References |
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Compounds | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Compounds | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Compounds | References |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | Compounds | References |
Escherichia coli | IMP dehydrogenase | Compounds | References |