Detailed view for TcCLB.511321.26

Basic information

TDR Targets ID: 43395
Trypanosoma cruzi, vesicle transport v-SNARE protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.5618 | Length (AA): 286 | MW (Da): 33044 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
178 256 1n7s (C) 5 83 25.00 0.0000023 0.05 0.58 -0.93
191 256 3b5n (C) 433 498 21.00 0 0.01 0.498469 -0.98
201 252 1nhl (A) 28 79 29.00 0 0.05 0.540518 -1.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131529)

Species Accession Gene Product
Arabidopsis thaliana AT3G29100   vesicle transport V-snare 13
Arabidopsis thaliana AT2G35190   novel plant SNARE 11
Babesia bovis BBOV_I001720   conserved hypothetical protein
Cryptosporidium hominis Chro.30485   hypothetical protein
Cryptosporidium parvum cgd3_4300   possible t-snare domain, possible transmembrane domain or GPI anchor signal at C-terminus
Dictyostelium discoideum DDB_G0285365   hypothetical protein
Drosophila melanogaster Dmel_CG44009   CG44009 gene product from transcript CG44009-RB
Entamoeba histolytica EHI_116720   hypothetical protein
Leishmania braziliensis LbrM.17.0360   Qa-SNARE protein, putative
Leishmania donovani LdBPK_170430.1   Qa-SNARE protein, putative
Leishmania infantum LinJ.17.0430   Qa-SNARE protein, putative
Leishmania major LmjF.17.0380   Qa-SNARE protein, putative
Leishmania mexicana LmxM.17.0380   hypothetical protein, conserved
Oryza sativa 4332931   Os03g0369800
Oryza sativa 9267986   Os06g0715100
Oryza sativa 4344040   Os07g0637400
Plasmodium berghei PBANKA_1312300   SNARE protein, putative
Plasmodium falciparum PF3D7_1448600   SNARE protein, putative
Plasmodium knowlesi PKNH_1233500   SNARE protein, putative
Plasmodium vivax PVX_118060   hypothetical protein, conserved
Plasmodium yoelii PY05111   Arabidopsis thaliana At2g35190/T4C15.14, putative
Trypanosoma brucei gambiense Tbg972.7.7450   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.6440   vesicle transport v-SNARE protein, putative
Trypanosoma congolense TcIL3000_7_5340   vesicle transport v-SNARE protein, putative
Trypanosoma cruzi TcCLB.511321.26   vesicle transport v-SNARE protein, putative
Trypanosoma cruzi TcCLB.510053.50   vesicle transport v-SNARE protein, putative
Toxoplasma gondii TGME49_306640   hypothetical protein
Theileria parva TP01_0526   hypothetical protein, conserved
Trichomonas vaginalis TVAG_446910   Novel plant SNARE, putative

Essentiality

TcCLB.511321.26 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.6440 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.6440 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.6440 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.6440 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1312300 Plasmodium berghei Essential plasmo
TGME49_306640 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511321.26 (Trypanosoma cruzi), vesicle transport v-SNARE protein, putative
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