Detailed view for TcCLB.508771.10

Basic information

TDR Targets ID: 44163
Trypanosoma cruzi, cysteine peptidase, Clan CA, family C51, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.288 | Length (AA): 195 | MW (Da): 21998 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05257   CHAP domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 195 2io8 (A) 10 193 32.00 0 1 1.30207 -0.23
10 155 2vob (A) 18 154 38.00 0.00000000051 1 1.09472 0.04
10 193 2vob (A) 18 191 31.00 0 1 1.23169 -0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_135897)

Species Accession Gene Product
Leishmania braziliensis LbrM.33.3140   D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative
Leishmania braziliensis LbrM.33.3110   D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative
Leishmania donovani LdBPK_332970.1   cysteine peptidase, Clan CA, family C51, putative
Leishmania donovani LdBPK_333000.1   cysteine peptidase, Clan CA, family C51, putative
Leishmania infantum LinJ.33.2970   D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative
Leishmania infantum LinJ.33.3000   D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative
Leishmania major LmjF.33.2850   D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative
Leishmania major LmjF.33.2830   D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative
Leishmania mexicana LmxM.32.2850   D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative
Leishmania mexicana LmxM.32.2830   D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative
Trypanosoma brucei gambiense Tbg.972.2.1900   D-alanyl-glycyl endopeptidase-like protein, putative,cysteine peptidase, Clan CA, family C51, putative
Trypanosoma brucei gambiense Tbg.972.2.1890   D-alanyl-glycyl endopeptidase-like protein, putative,cysteine peptidase, Clan CA, family C51, putative
Trypanosoma brucei Tb927.2.3440   cysteine peptidase, Clan CA, family C51, putative
Trypanosoma brucei Tb927.2.3460   cysteine peptidase, Clan CA, family C51, putative
Trypanosoma congolense TcIL3000_0_44670   cysteine peptidase, Clan CA, family C51, putative
Trypanosoma congolense TcIL3000_0_44680   cysteine peptidase, Clan CA, family C51, putative
Trypanosoma cruzi TcCLB.507715.10   cysteine peptidase, Clan CA, family C51, putative
Trypanosoma cruzi TcCLB.508771.10   cysteine peptidase, Clan CA, family C51, putative
Trypanosoma cruzi TcCLB.508771.20   cysteine peptidase, Clan CA, family C51, putative
Trypanosoma cruzi TcCLB.486465.9   cysteine peptidase, Clan CA, family C51, putative
Trypanosoma cruzi TcCLB.403875.10   cysteine peptidase, Clan CA, family C51, putative

Essentiality

TcCLB.508771.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.3440 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.3440 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.3440 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.3440 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.3460 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.3460 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.3460 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.2.3460 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative Compounds References
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0754 0.3563 0.3548
0.0369 0.3564 0.3564
0.0369 0.3577 0.3577
0.0684 0.3547 0.3538
0.0759 0.3547 0.3538
0.0716 0.2684 0.3679
0.0239 0.3439 0.3322
0.0168 0.3322 0.3322
0.0377 0.3513 0.3511
0.0244 0.3705 0.37
0.0327 0.334 0.3506
0.0716 0.3547 0.3538
0.0339 0.3512 0.3511
0.0679 0.2684 0.3679
0.0334 0.3254 0.3564
0.0313 0.3577 0.3577
0.0354 0.349 0.3619
0.0850606 0.421343 0.415749
0.0369 0.3564 0.3564
0.0609 0.2684 0.3679
0.0679 0.2684 0.3679
0.0305 0.3582 0.3577
0.0314 0.3468 0.3462
0.0716 0.3547 0.3538
0.0545 0.2691 0.3693
0.0311 0.3463 0.3458
0.0363 0.3622 0.3619
0.0762 0.3563 0.3547
0.034 0.3547 0.3547
0.0323 0.3646 0.3646
0.017 0.3538 0.3538
0.0336 0.3577 0.3577
0.0324 0.3577 0.3577
0.0319 0.32 0.3511
0.037 0.3665 0.3662
0.0679 0.2684 0.3679
0.0354 0.3548 0.3619
0.037 0.3665 0.3662
0.037 0.3622 0.3619
0.0362 0.3457 0.3441
0.0337 0.3512 0.3511
0.0321 0.3108 0.35
0.0647 0.3547 0.3538
0.0583 0.2724 0.3732
0.0724494 0.421438 0.415749
0.0754 0.3547 0.3538
0.0754 0.3547 0.3538
0.0307 0.3462 0.3462
0.0306 0.3622 0.3619
0.0303 0.3647 0.3619
0.034 0.3547 0.3547
0.0441407 0.399001 0.399001
0.0369 0.3564 0.3564
0.0647 0.3547 0.3538
0.0329 0.366 0.3646
0.0332 0.3135 0.3514
0.0332 0.3258 0.3523
0.0724494 0.421438 0.415749
0.0342 0.3564 0.3564
0.0366 0.3622 0.3619
0.0318 0.3468 0.3462
0.0309 0.2562 0.3466
0.0309 0.3517 0.3514
0.0302 0.3577 0.3577
0.0361 0.3538 0.349
0.0168 0.3421 0.335
0.0332 0.3503 0.3511
0.0324 0.3365 0.3305
0.0348 0.3564 0.3564
0.0336 0.3173 0.3517
0.031 0.3189 0.3621
0.0316 0.3564 0.3564
0.0308 0.3577 0.3577
0.0352 0.2619 0.3489
0.0545 0.2691 0.3693
0.033 0.3564 0.3564
0.0336 0.3577 0.3577
0.0358 0.2581 0.3462
0.0716 0.2665 0.3662
0.0341 0.3514 0.3489
0.0331 0.342 0.3483
0.0321 0.366 0.3645
0.0321 0.3564 0.3564
0.0325 0.3652 0.3646
0.0309 0.2562 0.3466
0.0305 0.3582 0.3577
0.0354 0.3548 0.3619
0.0754 0.3563 0.3548
0.0377 0.3648 0.3644
0.0328 0.3186 0.3646
0.0242 0.3566 0.3566
0.0367 0.366 0.3646
0.0377 0.3421 0.3358
0.0423818 0.295119 0.414922
0.0342 0.3564 0.3564
0.0312 0.3449 0.3411
0.0337 0.3423 0.3423
0.0684 0.3547 0.3538
0.0722 0.3547 0.3538
0.0377 0.3648 0.3644
0.0305 0.3577 0.3577
0.0334 0.3254 0.3564
0.0373 0.3622 0.3619
0.0313 0.3577 0.3577
0.0313 0.3577 0.3577
0.032 0.3564 0.3564
0.0305 0.3427 0.3322
0.0377 0.3648 0.3644
0.034 0.3439 0.3418
0.0304 0.3243 0.3549
0.0342 0.3577 0.3577
0.0311 0.3463 0.3458
0.0362 0.3577 0.3577
0.0354 0.3604 0.3654
0.0545 0.2598 0.3581
0.0307 0.2895 0.3501
0.0759 0.3547 0.3538
0.0304 0.3243 0.3549
0.0352 0.2619 0.3489
0.0242 0.3566 0.3566
0.0309 0.3652 0.3645
0.0759 0.3547 0.3538
0.0679 0.3547 0.3538
0.0242 0.3549 0.3538
0.0377 0.3443 0.3443
0.0313 0.3577 0.3577
0.0303 0.3577 0.3577
0.0377 0.3617 0.3564
0.0412 0.3034 0.3651
0.0342 0.3538 0.3538
0.0348 0.3592 0.3592
0.033 0.3486 0.3462
0.0321 0.3283 0.3662
0.0373 0.3578 0.3577
0.0355 0.3577 0.3577
0.0307 0.3391 0.3266
0.0313 0.2682 0.3322
0.0349 0.366 0.3646
0.0722 0.3547 0.3538
0.0306 0.3512 0.3511
0.0373 0.3622 0.3619
0.0366 0.3622 0.3619
0.0583 0.2724 0.3732
0.0306 0.3622 0.3619
0.0324 0.3577 0.3577
0.032 0.3564 0.3564
0.0309 0.3652 0.3645
0.0716 0.2684 0.3679
0.0316 0.3582 0.3577
0.0716 0.3547 0.3538
0.0342 0.3599 0.3619
0.0754 0.3538 0.3538
0.0716 0.2665 0.3662
0.0319 0.32 0.3511
0.0314 0.366 0.3645
0.0304 0.3243 0.3549
0.037 0.3665 0.3662
0.0363 0.3621 0.3619
0.0321 0.3283 0.3662
0.0321 0.3283 0.3662
0.0307 0.2895 0.3501
0.034 0.3547 0.3547
0.0318 0.366 0.3645
0.0302 0.3382 0.3662
0.0324 0.3564 0.3564
0.0307 0.3406 0.3406
0.0362 0.3457 0.3441
0.0365 0.3564 0.3564
0.0716 0.2665 0.3662
0.0351 0.3487 0.3462
0.0679 0.3547 0.3538
0.0311 0.3489 0.3489
0.0716 0.2665 0.3662
0.0684 0.3547 0.3538
0.0306 0.3652 0.3645
0.0313 0.3577 0.3577
0.0545 0.3547 0.3538
0.0716 0.3547 0.3538
0.0722 0.3547 0.3538
0.0325 0.3489 0.3489
0.0325 0.3468 0.3462
0.0321 0.3485 0.3462
0.0342 0.366 0.3646
0.034 0.3498 0.3519

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.508771.10 (Trypanosoma cruzi), cysteine peptidase, Clan CA, family C51, putative
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