Detailed view for LmxM.29.3550

Basic information

TDR Targets ID: 446709
Leishmania mexicana, cytochrome p450-like protein
Source Database / ID: 

pI: 7.1354 | Length (AA): 509 | MW (Da): 58365 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 502 4lxj (A) 17 528 19.00 0 1 1.1686 -0.04
52 492 2ve3 (A) 20 436 26.00 0 1 1.2027 -0.63
68 498 3mdm (A) 64 489 17.00 0 1 1.05886 -0.4
364 464 3r9b (A) 293 384 35.00 0.0091 0.75 0.421728 0.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131167)

Species Accession Gene Product
Arabidopsis thaliana AT2G28860   cytochrome P450 710A4
Arabidopsis thaliana AT2G34500   cytochrome P450 710A1
Arabidopsis thaliana AT2G34490   cytochrome P450 710A2
Arabidopsis thaliana AT2G28850   cytochrome P450 710A3
Candida albicans CaO19.12645   cytochrome P450 similar to S. cerevisiae ERG5 (YMR015C) C-22 sterol desaturase
Candida albicans CaO19.5178   cytochrome P450 similar to S. cerevisiae ERG5 (YMR015C) C-22 sterol desaturase
Candida albicans CaO19_5178   hypothetical protein
Dictyostelium discoideum DDB_G0269016   cytochrome P450 family protein
Drosophila melanogaster Dmel_CG4321   Cytochrome P450-4d8
Leishmania braziliensis LbrM.30.3580   cytochrome p450-like protein
Leishmania donovani LdBPK_303610.1   cytochrome p450-like protein
Leishmania infantum LinJ.30.3610   cytochrome p450-like protein
Leishmania major LmjF.30.3550   cytochrome p450-like protein
Leishmania mexicana LmxM.29.3550   cytochrome p450-like protein
Oryza sativa 4325563   Os01g0211200
Oryza sativa 4325564   Os01g0211600
Oryza sativa 9267882   Os01g0211000
Oryza sativa 9267503   Os03g0836100
Oryza sativa 4325562   Os01g0210900
Saccharomyces cerevisiae YMR015C   C-22 sterol desaturase
Trypanosoma cruzi TcCLB.506945.190   cytochrome p450-like protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major lanosterol 14-alpha-demethylase, putative 479 aa 22.8% 438 aa Compounds References
Rattus norvegicus Cytochrome P450 51 503 aa 21.2% 419 aa Compounds References
Sorghum bicolor Obtusifoliol 14-alpha demethylase 492 aa 22.6% 451 aa Compounds References
Rattus norvegicus Cytochrome P450 3A1 504 aa 21.3% 456 aa Compounds References
Trypanosoma cruzi Lanosterol 14-alpha demethylase 481 aa 24.2% 500 aa Compounds References
Trypanosoma cruzi Lanosterol 14-alpha demethylase 481 aa 24.0% 500 aa Compounds References
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 451 aa 22.4% 433 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.29.3550 (Leishmania mexicana), cytochrome p450-like protein
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