pI: 9.6951 |
Length (AA): 86 |
MW (Da): 9564 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127008)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G47930 | 40S ribosomal protein S27-3 |
Arabidopsis thaliana | AT3G61111 | zinc-binding ribosomal protein family protein |
Arabidopsis thaliana | AT2G45710 | 40S ribosomal protein S27-1 |
Arabidopsis thaliana | AT3G61110 | 40S ribosomal protein S27-2 |
Babesia bovis | BBOV_III003560 | 40S ribosomal protein S27, putative |
Brugia malayi | Bm1_03910 | 40S ribosomal protein S27 |
Caenorhabditis elegans | CELE_F56E10.4 | Protein RPS-27 |
Cryptosporidium hominis | Chro.70173 | 40S ribosomal protein S27 |
Cryptosporidium parvum | cgd7_1460 | ribosomal protein S27 |
Dictyostelium discoideum | DDB_G0277635 | 40S ribosomal protein S27 |
Drosophila melanogaster | Dmel_CG10423 | Ribosomal protein S27 |
Echinococcus granulosus | EgrG_000297000 | ribosomal protein S27 |
Entamoeba histolytica | EHI_152230 | 40S ribosomal protein S27, putative |
Entamoeba histolytica | EHI_004200 | 40S ribosomal protein S27, putative |
Entamoeba histolytica | EHI_149000 | 40S ribosomal protein S27 |
Echinococcus multilocularis | EmuJ_000297000 | ribosomal protein S27 |
Giardia lamblia | GL50803_10780 | Ribosomal protein S27 |
Homo sapiens | ENSG00000177954 | ribosomal protein S27 |
Homo sapiens | 51065 | ribosomal protein S27-like |
Leishmania braziliensis | LbrM.35.3990 | 40S ribosomal protein S27-1, putative |
Leishmania braziliensis | LbrM.18.0670 | 40S ribosomal protein S27-1 |
Leishmania donovani | LdBPK_363940.1 | 40S ribosomal protein S27-1, putative |
Leishmania infantum | LinJ.36.3940 | 40S ribosomal protein S27-1, putative |
Leishmania major | LmjF.36.3750 | 40S ribosomal protein S27-1, putative |
Leishmania mexicana | LmxM.36.3750 | 40S ribosomal protein S27-1, putative |
Loa Loa (eye worm) | LOAG_03894 | 40S ribosomal protein S27 |
Mus musculus | 57294 | ribosomal protein S27 |
Mus musculus | ENSMUSG00000050621 | ribosomal protein S27, retrogene |
Mus musculus | ENSMUSG00000036781 | ribosomal protein S27-like |
Neospora caninum | NCLIV_062350 | Ribosomal protein S27, related |
Oryza sativa | 4329362 | Os02g0478700 |
Oryza sativa | 4335531 | Os04g0346100 |
Plasmodium berghei | PBANKA_1406800 | 40S ribosomal protein S27, putative |
Plasmodium falciparum | PF3D7_1308300 | 40S ribosomal protein S27 |
Plasmodium knowlesi | PKNH_1408700 | 40S ribosomal protein S27, putative |
Plasmodium vivax | PVX_122245 | 40S ribosomal protein S27, putative |
Plasmodium yoelii | PY03153 | ribosomal protein S27 |
Saccharomyces cerevisiae | YKL156W | ribosomal 40S subunit protein S27A |
Saccharomyces cerevisiae | YHR021C | ribosomal 40S subunit protein S27B |
Schistosoma japonicum | Sjp_0202200 | ko:K02978 small subunit ribosomal protein S27e, putative |
Schistosoma mansoni | Smp_041650 | 40S ribosomal protein S27 |
Schmidtea mediterranea | mk4.008691.00 | 40S ribosomal protein S27 |
Trypanosoma brucei gambiense | Tbg972.11.10910 | 40S ribosomal protein S27, putative |
Trypanosoma brucei | Tb927.10.13517 | 40S ribosomal protein S27-like, putative |
Trypanosoma cruzi | TcCLB.506963.14 | 40S ribosomal protein S27, putative |
Trypanosoma cruzi | TcCLB.511233.14 | 40S ribosomal protein S27, putative |
Trypanosoma cruzi | TcCLB.511277.175 | ribosomal protein S27, putative |
Toxoplasma gondii | TGME49_217570 | ribosomal protein RPS27 |
Theileria parva | TP03_0052 | 40S ribosomal protein S27, putative |
Trichomonas vaginalis | TVAG_064320 | 40S ribosomal protein S27, putative |
Trichomonas vaginalis | TVAG_378970 | 40S ribosomal protein S27, putative |
Trichomonas vaginalis | TVAG_110520 | 40S ribosomal protein S27, putative |
Trichomonas vaginalis | TVAG_356540 | 40S ribosomal protein S27, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.1475 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.1475 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.1475 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb11.01.1475 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F56E10.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F56E10.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F56E10.4 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1406800 | Plasmodium berghei | Essential | plasmo |
TGME49_217570 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ribosomal protein S27 | Compounds | References |