Detailed view for NCLIV_068740

Basic information

TDR Targets ID: 476457
Neospora caninum, Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related
Source Database / ID: 

pI: 8.4888 | Length (AA): 292 | MW (Da): 34332 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00479   Glucose-6-phosphate dehydrogenase, NAD binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0050661   NADP binding  
GO:0004345   glucose-6-phosphate dehydrogenase activity  
GO:0055114   oxidation reduction  
GO:0006006   glucose metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 289 2bh9 (A) 28 230 38.00 0 1 0.978432 0.91
17 289 5aq1 (A) 65 276 37.00 0 1 0.991432 1.08
174 246 5kzm (A) 78 147 27.00 0.39 0.17 0.4873 -0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127121)

Species Accession Gene Product
Arabidopsis thaliana AT5G40760   glucose-6-phosphate dehydrogenase 6
Arabidopsis thaliana AT1G24280   glucose-6-phosphate dehydrogenase 3
Arabidopsis thaliana AT3G27300   glucose-6-phosphate dehydrogenase 5
Arabidopsis thaliana AT5G35790   glucose-6-phosphate dehydrogenase 1
Arabidopsis thaliana AT5G13110   glucose-6-phosphate dehydrogenase 2
Babesia bovis BBOV_IV001600   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
Brugia malayi Bm1_36755   glucose-6-phosphate dehydrogenase
Candida albicans CaO19.12218   likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C)
Candida albicans CaO19.4754   likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C)
Caenorhabditis elegans CELE_B0035.5   Protein GSPD-1
Chlamydia trachomatis CT_185   glucose-6-phosphate 1-dehydrogenase
Dictyostelium discoideum DDB_G0273639   glucose 6-phosphate-1-dehydrogenase
Dictyostelium discoideum DDB_G0273131   glucose 6-phosphate-1-dehydrogenase
Drosophila melanogaster Dmel_CG12529   Zwischenferment
Drosophila melanogaster Dmel_CG7140   CG7140 gene product from transcript CG7140-RB
Escherichia coli b1852   glucose-6-phosphate 1-dehydrogenase
Echinococcus granulosus EgrG_000126400   glucose 6 phosphate 1 dehydrogenase
Echinococcus multilocularis EmuJ_000126400   glucose 6 phosphate 1 dehydrogenase
Giardia lamblia GL50803_8682   Glucose-6-phosphate 1-dehydrogenase
Homo sapiens ENSG00000160211   glucose-6-phosphate dehydrogenase
Leishmania braziliensis LbrM.20.0160   glucose-6-phosphate 1-dehydrogenase, putative
Leishmania donovani LdBPK_340080.1   glucose-6-phosphate 1-dehydrogenase, putative
Leishmania infantum LinJ.34.0080   glucose-6-phosphate 1-dehydrogenase, putative
Leishmania major LmjF.34.0080   glucose-6-phosphate 1-dehydrogenase, putative
Leishmania mexicana LmxM.33.0080   glucose-6-phosphate dehydrogenase
Loa Loa (eye worm) LOAG_04956   glucose-6-phosphate dehydrogenase
Mus musculus ENSMUSG00000089992   glucose-6-phosphate dehydrogenase 2
Mus musculus ENSMUSG00000031400   glucose-6-phosphate dehydrogenase X-linked
Mycobacterium tuberculosis Rv1447c   Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)
Mycobacterium ulcerans MUL_1842   glucose-6-phosphate 1-dehydrogenase
Neospora caninum NCLIV_068740   Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related
Neospora caninum NCLIV_067180   Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related
Oryza sativa 4336209   Os04g0485300
Oryza sativa 4342988   Os07g0406300
Oryza sativa 4333103   Os03g0412800
Oryza sativa 4329889   Os02g0600400
Plasmodium berghei PBANKA_1317500   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative
Plasmodium falciparum PF3D7_1453800   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
Plasmodium knowlesi PKNH_1228300   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative
Plasmodium vivax PVX_117790   glucose-6-phosphate 1-dehydrogenase, putative
Plasmodium yoelii PY00793   Glucose-6-phosphate dehydrogenase, putative
Saccharomyces cerevisiae YNL241C   glucose-6-phosphate dehydrogenase
Schistosoma japonicum Sjp_0026090   ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative
Schistosoma mansoni Smp_052810   glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.062629.00  
Schmidtea mediterranea mk4.053429.00  
Schmidtea mediterranea mk4.014447.00   Glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.025737.00   Glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.011860.01   Glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.045079.00   Glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.062629.01   Putative 6-phosphogluconolactonase
Trypanosoma brucei gambiense Tbg972.10.3100   glucose-6-phosphate 1-dehydrogenase, putative
Trypanosoma brucei Tb927.10.2490   glucose-6-phosphate 1-dehydrogenase
Trypanosoma congolense TcIL3000_10_2120   glucose-6-phosphate 1-dehydrogenase, putative
Trypanosoma cruzi TcCLB.509287.50   glucose-6-phosphate 1-dehydrogenase, putative
Toxoplasma gondii TGME49_278830   glucose-6-phosphate 1-dehydrogenase
Treponema pallidum TP0478   glucose-6-phosphate 1-dehydrogenase
Theileria parva TP03_0558   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative
Trichomonas vaginalis TVAG_414060   glucosamine-6-phosphate isomerase, putative
Trichomonas vaginalis TVAG_094630   glucosamine-6-phosphate isomerase, putative
Trichomonas vaginalis TVAG_089600   6-phosphogluconolactonase, putative

Essentiality

NCLIV_068740 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2490 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.2490 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.2490 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.2490 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b1852 Escherichia coli essential goodall
CELE_B0035.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0035.5 Caenorhabditis elegans slow growth wormbase
CELE_B0035.5 Caenorhabditis elegans sterile wormbase
YNL241C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1317500 Plasmodium berghei Slow plasmo
TGME49_278830 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Saccharomyces cerevisiae glucose-6-phosphate dehydrogenase Compounds References
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Compounds References
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Compounds References
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Compounds References
Homo sapiens glucose-6-phosphate dehydrogenase Compounds References
Plasmodium falciparum Glucose-6-phosphate 1-dehydrogenase Compounds References
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier NCLIV_068740 (Neospora caninum), Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related
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