pI: 6.2621 |
Length (AA): 513 |
MW (Da): 59267 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 505 | 6d23 (C) | 53 | 545 | 48.00 | 0 | 1 | 1.60671 | -1.08 |
24 | 510 | 6e08 (L) | 28 | 509 | 59.00 | 0 | 1 | 1.75692 | -1.4 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127121)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G40760 | glucose-6-phosphate dehydrogenase 6 |
Arabidopsis thaliana | AT1G24280 | glucose-6-phosphate dehydrogenase 3 |
Arabidopsis thaliana | AT3G27300 | glucose-6-phosphate dehydrogenase 5 |
Arabidopsis thaliana | AT5G35790 | glucose-6-phosphate dehydrogenase 1 |
Arabidopsis thaliana | AT5G13110 | glucose-6-phosphate dehydrogenase 2 |
Babesia bovis | BBOV_IV001600 | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
Brugia malayi | Bm1_36755 | glucose-6-phosphate dehydrogenase |
Candida albicans | CaO19.12218 | likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) |
Candida albicans | CaO19.4754 | likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) |
Caenorhabditis elegans | CELE_B0035.5 | Protein GSPD-1 |
Chlamydia trachomatis | CT_185 | glucose-6-phosphate 1-dehydrogenase |
Dictyostelium discoideum | DDB_G0273639 | glucose 6-phosphate-1-dehydrogenase |
Dictyostelium discoideum | DDB_G0273131 | glucose 6-phosphate-1-dehydrogenase |
Drosophila melanogaster | Dmel_CG12529 | Zwischenferment |
Drosophila melanogaster | Dmel_CG7140 | CG7140 gene product from transcript CG7140-RB |
Escherichia coli | b1852 | glucose-6-phosphate 1-dehydrogenase |
Echinococcus granulosus | EgrG_000126400 | glucose 6 phosphate 1 dehydrogenase |
Echinococcus multilocularis | EmuJ_000126400 | glucose 6 phosphate 1 dehydrogenase |
Giardia lamblia | GL50803_8682 | Glucose-6-phosphate 1-dehydrogenase |
Homo sapiens | ENSG00000160211 | glucose-6-phosphate dehydrogenase |
Leishmania braziliensis | LbrM.20.0160 | glucose-6-phosphate 1-dehydrogenase, putative |
Leishmania donovani | LdBPK_340080.1 | glucose-6-phosphate 1-dehydrogenase, putative |
Leishmania infantum | LinJ.34.0080 | glucose-6-phosphate 1-dehydrogenase, putative |
Leishmania major | LmjF.34.0080 | glucose-6-phosphate 1-dehydrogenase, putative |
Leishmania mexicana | LmxM.33.0080 | glucose-6-phosphate dehydrogenase |
Loa Loa (eye worm) | LOAG_04956 | glucose-6-phosphate dehydrogenase |
Mus musculus | ENSMUSG00000089992 | glucose-6-phosphate dehydrogenase 2 |
Mus musculus | ENSMUSG00000031400 | glucose-6-phosphate dehydrogenase X-linked |
Mycobacterium tuberculosis | Rv1447c | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) |
Mycobacterium ulcerans | MUL_1842 | glucose-6-phosphate 1-dehydrogenase |
Neospora caninum | NCLIV_068740 | Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related |
Neospora caninum | NCLIV_067180 | Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related |
Oryza sativa | 4336209 | Os04g0485300 |
Oryza sativa | 4342988 | Os07g0406300 |
Oryza sativa | 4333103 | Os03g0412800 |
Oryza sativa | 4329889 | Os02g0600400 |
Plasmodium berghei | PBANKA_1317500 | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative |
Plasmodium falciparum | PF3D7_1453800 | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
Plasmodium knowlesi | PKNH_1228300 | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative |
Plasmodium vivax | PVX_117790 | glucose-6-phosphate 1-dehydrogenase, putative |
Plasmodium yoelii | PY00793 | Glucose-6-phosphate dehydrogenase, putative |
Saccharomyces cerevisiae | YNL241C | glucose-6-phosphate dehydrogenase |
Schistosoma japonicum | Sjp_0026090 | ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative |
Schistosoma mansoni | Smp_052810 | glucose-6-phosphate 1-dehydrogenase |
Schmidtea mediterranea | mk4.062629.00 | |
Schmidtea mediterranea | mk4.053429.00 | |
Schmidtea mediterranea | mk4.014447.00 | Glucose-6-phosphate 1-dehydrogenase |
Schmidtea mediterranea | mk4.025737.00 | Glucose-6-phosphate 1-dehydrogenase |
Schmidtea mediterranea | mk4.011860.01 | Glucose-6-phosphate 1-dehydrogenase |
Schmidtea mediterranea | mk4.045079.00 | Glucose-6-phosphate 1-dehydrogenase |
Schmidtea mediterranea | mk4.062629.01 | Putative 6-phosphogluconolactonase |
Trypanosoma brucei gambiense | Tbg972.10.3100 | glucose-6-phosphate 1-dehydrogenase, putative |
Trypanosoma brucei | Tb927.10.2490 | glucose-6-phosphate 1-dehydrogenase |
Trypanosoma congolense | TcIL3000_10_2120 | glucose-6-phosphate 1-dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.509287.50 | glucose-6-phosphate 1-dehydrogenase, putative |
Toxoplasma gondii | TGME49_278830 | glucose-6-phosphate 1-dehydrogenase |
Treponema pallidum | TP0478 | glucose-6-phosphate 1-dehydrogenase |
Theileria parva | TP03_0558 | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative |
Trichomonas vaginalis | TVAG_414060 | glucosamine-6-phosphate isomerase, putative |
Trichomonas vaginalis | TVAG_094630 | glucosamine-6-phosphate isomerase, putative |
Trichomonas vaginalis | TVAG_089600 | 6-phosphogluconolactonase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.2490 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2490 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2490 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.2490 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1852 | Escherichia coli | essential | goodall |
CELE_B0035.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0035.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_B0035.5 | Caenorhabditis elegans | sterile | wormbase |
YNL241C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1317500 | Plasmodium berghei | Slow | plasmo |
TGME49_278830 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | inferred from specific protein inhibition (ECO:0000020) | Schistosoma japonicum | 101154 579291 579292 | ||
Annotator: | stewac@u.washington.edu. | Comment: | 2009/03/25. | References: | 10678112 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Compound | Source | Reference |
---|---|---|
Curated by TDRTargets | References | |
Curated by TDRTargets | References | |
Curated by TDRTargets | References |
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | Glucose-6-phosphate 1-dehydrogenase | Compounds | References |
Trypanosoma brucei gambiense | glucose-6-phosphate 1-dehydrogenase, putative | Compounds | References |
Saccharomyces cerevisiae | glucose-6-phosphate dehydrogenase | Compounds | References |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | Compounds | References |
Plasmodium berghei | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative | Compounds | References |
Homo sapiens | glucose-6-phosphate dehydrogenase | Compounds | References |