Detailed view for TcCLB.509171.100

Basic information

TDR Targets ID: 47819
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.0462 | Length (AA): 636 | MW (Da): 69912 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 92 3qbt (B) 563 638 17.00 0 0.08 0.194608 0.23
76 313 2j3s (A) 2056 2315 23.00 0.88 0.7 0.373614 1.3
185 313 4p3w (F) 2197 2315 28.00 0.12 0.07 0.21523 1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128968)

Species Accession Gene Product
Echinococcus granulosus EgrG_000863000   leucine rich repeat flightless interacting
Echinococcus granulosus EgrG_001163700   hydrocephalus inducing
Echinococcus multilocularis EmuJ_000863000   leucine rich repeat flightless interacting
Echinococcus multilocularis EmuJ_001163700   hydrocephalus inducing
Homo sapiens ENSG00000157423   HYDIN, axonemal central pair apparatus protein
Homo sapiens 101930373   hydrocephalus-inducing protein homolog
Leishmania braziliensis LbrM.17.0870   hypothetical protein, conserved
Leishmania donovani LdBPK_301810.1   Zeta toxin, putative
Leishmania infantum LinJ.30.1810   hypothetical protein, conserved
Leishmania major LmjF.30.1810   hypothetical protein, conserved
Leishmania mexicana LmxM.29.1810   hypothetical protein, conserved
Mus musculus ENSMUSG00000059854   HYDIN, axonemal central pair apparatus protein
Neospora caninum NCLIV_044250   hypothetical protein, conserved
Schistosoma japonicum Sjp_0003880   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0104760   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0304440   Leucine-rich repeat flightless-interacting protein 2, putative
Schistosoma japonicum Sjp_0003890   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0003900   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0118680   hypothetical protein
Schistosoma japonicum Sjp_0109230   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0118340   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0003910   Hydrocephalus-inducing protein, putative
Schistosoma mansoni Smp_175450   hypothetical protein
Schistosoma mansoni Smp_175460   hypothetical protein
Schmidtea mediterranea mk4.000152.18   Hydrocephalus-inducing protein homolog
Trypanosoma brucei gambiense Tbg972.6.2940   Hydin,flagellar component
Trypanosoma brucei Tb927.6.3150   Hydin
Trypanosoma congolense TcIL3000_0_11680   Hydin
Trypanosoma cruzi TcCLB.509173.9   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509171.100   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507023.220   hypothetical protein, conserved
Toxoplasma gondii TGME49_206550   hypothetical protein
Trichomonas vaginalis TVAG_481960   conserved hypothetical protein
Trichomonas vaginalis TVAG_129800   conserved hypothetical protein
Trichomonas vaginalis TVAG_241570   conserved hypothetical protein
Trichomonas vaginalis TVAG_169860   conserved hypothetical protein
Trichomonas vaginalis TVAG_130090   conserved hypothetical protein
Trichomonas vaginalis TVAG_309160   conserved hypothetical protein
Trichomonas vaginalis TVAG_449190   conserved hypothetical protein
Trichomonas vaginalis TVAG_412510   conserved hypothetical protein
Trichomonas vaginalis TVAG_041110   conserved hypothetical protein
Trichomonas vaginalis TVAG_069480   conserved hypothetical protein
Trichomonas vaginalis TVAG_457560   conserved hypothetical protein

Essentiality

TcCLB.509171.100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.3150 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.3150 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.3150 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.3150 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_206550 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.509171.100 (Trypanosoma cruzi), hypothetical protein, conserved
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