Detailed view for NCLIV_002760

Basic information

TDR Targets ID: 479185
Neospora caninum, CMGC kinase, MAPK family, putative
Source Database / ID: 

pI: 7.7616 | Length (AA): 548 | MW (Da): 62191 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004707   MAP kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

EGFR tyrosine kinase inhibitor resistance (KEGG)
Endocrine resistance (KEGG)
Platinum drug resistance (KEGG)
MAPK signaling pathway (KEGG)
MAPK signaling pathway - yeast (KEGG)
ErbB signaling pathway (KEGG)
MAPK signaling pathway - fly (KEGG)
Ras signaling pathway (KEGG)
Rap1 signaling pathway (KEGG)
cGMP-PKG signaling pathway (KEGG)
cAMP signaling pathway (KEGG)
Chemokine signaling pathway (KEGG)
HIF-1 signaling pathway (KEGG)
FoxO signaling pathway (KEGG)
Sphingolipid signaling pathway (KEGG)
Phospholipase D signaling pathway (KEGG)
Oocyte meiosis (KEGG)
Regulation of autophagy (KEGG)
mTOR signaling pathway (KEGG)
PI3K-Akt signaling pathway (KEGG)
Apoptosis (KEGG)
Apoptosis - fly (KEGG)
Cellular senescence (KEGG)
Adrenergic signaling in cardiomyocytes (KEGG)
Vascular smooth muscle contraction (KEGG)
Dorso-ventral axis formation (KEGG)
TGF-beta signaling pathway (KEGG)
Axon guidance (KEGG)
VEGF signaling pathway (KEGG)
Apelin signaling pathway (KEGG)
Osteoclast differentiation (KEGG)
Focal adhesion (KEGG)
Adherens junction (KEGG)
Gap junction (KEGG)
Signaling pathways regulating pluripotency of stem cells (KEGG)
Platelet activation (KEGG)
Toll-like receptor signaling pathway (KEGG)
NOD-like receptor signaling pathway (KEGG)
Natural killer cell mediated cytotoxicity (KEGG)
IL-17 signaling pathway (KEGG)
Th1 and Th2 cell differentiation (KEGG)
Th17 cell differentiation (KEGG)
T cell receptor signaling pathway (KEGG)
B cell receptor signaling pathway (KEGG)
Fc epsilon RI signaling pathway (KEGG)
Fc gamma R-mediated phagocytosis (KEGG)
TNF signaling pathway (KEGG)
Circadian entrainment (KEGG)
Long-term potentiation (KEGG)
Neurotrophin signaling pathway (KEGG)
Retrograde endocannabinoid signaling (KEGG)
Glutamatergic synapse (KEGG)
Cholinergic synapse (KEGG)
Serotonergic synapse (KEGG)
Long-term depression (KEGG)
Regulation of actin cytoskeleton (KEGG)
Insulin signaling pathway (KEGG)
GnRH signaling pathway (KEGG)
Progesterone-mediated oocyte maturation (KEGG)
Estrogen signaling pathway (KEGG)
Melanogenesis (KEGG)
Prolactin signaling pathway (KEGG)
Thyroid hormone signaling pathway (KEGG)
Oxytocin signaling pathway (KEGG)
Type II diabetes mellitus (KEGG)
AGE-RAGE signaling pathway in diabetic complications (KEGG)
Aldosterone-regulated sodium reabsorption (KEGG)
Alzheimer's disease (KEGG)
Prion diseases (KEGG)
Alcoholism (KEGG)
Shigellosis (KEGG)
Salmonella infection (KEGG)
Pertussis (KEGG)
Leishmaniasis (KEGG)
Chagas disease (KEGG)
Toxoplasmosis (KEGG)
Tuberculosis (KEGG)
Hepatitis C (KEGG)
Hepatitis B (KEGG)
Influenza A (KEGG)
Human papillomavirus infection (KEGG)
Kaposi's sarcoma-associated herpesvirus infection (KEGG)
Pathways in cancer (KEGG)
Viral carcinogenesis (KEGG)
Proteoglycans in cancer (KEGG)
Colorectal cancer (KEGG)
Renal cell carcinoma (KEGG)
Pancreatic cancer (KEGG)
Endometrial cancer (KEGG)
Glioma (KEGG)
Prostate cancer (KEGG)
Thyroid cancer (KEGG)
Melanoma (KEGG)
Bladder cancer (KEGG)
Chronic myeloid leukemia (KEGG)
Acute myeloid leukemia (KEGG)
Non-small cell lung cancer (KEGG)
Breast cancer (KEGG)
Central carbon metabolism in cancer (KEGG)
Choline metabolism in cancer (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 140 4zia (A) 6 113 11.00 0 0.01 0.34118 -0.85
64 491 3kvw (A) 80 463 27.00 0 1 0.744022 0.62
135 540 3rp9 (A) 45 450 99.00 0 1 1.75688 -1.01
143 291 2vd5 (A) 69 215 28.00 0.0025 0.36 0.344898 0.58
151 493 3ddq (C) 10 289 47.00 0 1 0.719912 0.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138034)

Species Accession Gene Product
Babesia bovis BBOV_IV005520   mitogen-activated protein kinase, putative
Cryptosporidium hominis Chro.20465   mitogen-activated protein kinase 2
Cryptosporidium parvum cgd2_4340   mitogen-activated protein kinase 2, putative
Neospora caninum NCLIV_002760   CMGC kinase, MAPK family, putative
Plasmodium berghei PBANKA_0933700   mitogen-activated protein kinase 2
Plasmodium falciparum PF3D7_1113900   mitogen-activated protein kinase 2
Plasmodium knowlesi PKNH_0911500   mitogen-activated protein kinase 2, putative
Plasmodium vivax PVX_091340   mitogen-activated protein kinase 2, putative
Plasmodium yoelii PY00731   mitogen-activated protein kinase 2
Toxoplasma gondii TGME49_207820   cell-cycle-associated protein kinase MAPK, putative
Theileria parva TP01_0359   mitogen-activated protein kinase 2, putative

Essentiality

NCLIV_002760 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0933700 Plasmodium berghei Dispensable plasmo
TGME49_207820 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum mitogen-activated protein kinase 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Glycogen synthase kinase 3 beta 420 aa 31.2% 375 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 33.0% 367 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 32.8% 354 aa Compounds References
Rattus norvegicus Glycogen synthase kinase-3 beta 420 aa 30.9% 375 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 33.4% 350 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 37.1% 394 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 34.6% 355 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 34.6% 205 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 26.0% 296 aa Compounds References
Patiria pectinifera Cdc2 300 aa 31.0% 345 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 32.4% 346 aa Compounds References
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 419 aa 31.2% 375 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 26.8% 380 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier NCLIV_002760 (Neospora caninum), CMGC kinase, MAPK family, putative
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