Detailed view for TcCLB.509569.120

Basic information

TDR Targets ID: 48440
Trypanosoma cruzi, RNA-binding protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.9965 | Length (AA): 403 | MW (Da): 44911 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  
GO:0000166   nucleotide binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
121 269 1n52 (B) 20 151 14.00 0 0.84 0.28 0.54
128 233 2cq4 (A) 126 231 20.00 0.000000038 1 0.56 -0.38
149 263 2adc (A) 336 445 13.00 0.000051 0.31 0.4 -0.24
151 227 1hd0 (A) 98 172 23.00 0.00000000032 1 0.63 -1.38
68 143 5hzp (C) 56 126 11.00 0 0 0.339786 -1.36
90 222 3smz (A) 76 203 29.00 0.014 1 0.617525 -0.34
157 225 1whw (A) 45 112 25.00 0 1 0.529416 -0.48
194 244 1qo0 (D) 83 137 35.00 0.75 0.29 0.388051 0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128388)

Species Accession Gene Product
Arabidopsis thaliana AT5G04600   RNA recognition motif-containing protein
Babesia bovis BBOV_IV003970   RNA recognition motif containing protein
Brugia malayi Bm1_45185   putative RNA binding protein
Candida albicans CaO19.7050   RRM-containing orf similar to SPCC1827.05c and to NOP15
Candida albicans CaO19_7050   hypothetical protein
Caenorhabditis elegans CELE_T04A8.6   Protein T04A8.6
Cryptosporidium hominis Chro.70191   mki67 (FHA domain) interacting nucleolar phosphoprotein (human) - like
Cryptosporidium parvum cgd7_1620   nop15p/nopp34; nucleolar protein with 1 RRM domain
Dictyostelium discoideum DDB_G0275885   hypothetical protein
Drosophila melanogaster Dmel_CG6937   CG6937 gene product from transcript CG6937-RA
Entamoeba histolytica EHI_068680   nucleolar phosphoprotein Nopp34, putative
Echinococcus multilocularis EmuJ_000452900   expressed protein
Giardia lamblia GL50803_6054   RNA binding protein, putative
Homo sapiens ENSG00000155438   nucleolar protein interacting with the FHA domain of MKI67
Leishmania braziliensis LbrM.10.1130   RNA-binding protein-like protein
Leishmania donovani LdBPK_101110.1   RNA-binding protein-like protein
Leishmania infantum LinJ.10.1110   RNA-binding protein-like protein
Leishmania major LmjF.10.1030   RNA-binding protein-like protein
Leishmania mexicana LmxM.10.1030   RNA-binding protein-like protein
Loa Loa (eye worm) LOAG_00920   hypothetical protein
Mus musculus ENSMUSG00000026377   nucleolar protein interacting with the FHA domain of MKI67
Neospora caninum NCLIV_052320   RNA binding protein, putative
Oryza sativa 4345558   Os08g0412200
Saccharomyces cerevisiae YNL110C   Nop15p
Schistosoma mansoni Smp_078520   nucleolar phosphoprotein
Trypanosoma brucei gambiense Tbg972.8.4210   RNA-binding protein, putative
Trypanosoma brucei Tb927.8.4450   RNA-binding protein, putative
Trypanosoma congolense TcIL3000_8_4220   RNA-binding protein, putative
Trypanosoma cruzi TcCLB.509569.120   RNA-binding protein, putative
Trypanosoma cruzi TcCLB.508989.30   RNA-binding protein, putative
Toxoplasma gondii TGME49_215400   RNA recognition motif-containing protein
Theileria parva TP01_1032   RNA-binding protein, putative
Trichomonas vaginalis TVAG_139660   conserved hypothetical protein
Trichomonas vaginalis TVAG_286120   conserved hypothetical protein

Essentiality

TcCLB.509569.120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.4450 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.4450 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.4450 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.4450 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T04A8.6 Caenorhabditis elegans larval arrest wormbase
CELE_T04A8.6 Caenorhabditis elegans slow growth wormbase
CELE_T04A8.6 Caenorhabditis elegans sterile wormbase
YNL110C Saccharomyces cerevisiae inviable yeastgenome
TGME49_215400 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.509569.120 (Trypanosoma cruzi), RNA-binding protein, putative
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