Detailed view for TcCLB.508731.9

Basic information

TDR Targets ID: 52006
Trypanosoma cruzi, Uncharacterised ACR, YagE family COG1723, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.2355 | Length (AA): 419 | MW (Da): 47567 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02582   Uncharacterised ACR, YagE family COG1723

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127371)

Species Accession Gene Product
Arabidopsis thaliana AT5G13610   hypothetical protein
Arabidopsis thaliana AT1G69380   hypothetical protein
Brugia malayi Bm1_12970   Uncharacterized ACR, YagE family COG1723 containing protein
Candida albicans CaO19.1617   similar to S. cerevisiae YDR282C
Candida albicans CaO19.9184   similar to S. cerevisiae YDR282C
Candida albicans CaO19.3158   similar to S. cerevisiae gene Required for Meiotic Division
Candida albicans CaO19.10667   similar to S. cerevisiae gene Required for Meiotic Division
Caenorhabditis elegans CELE_ZK1010.2   Protein ZK1010.2
Cryptosporidium hominis Chro.40468   hypothetical protein
Cryptosporidium parvum cgd4_4110   hypothetical conserved protein, possible transmembrane domain near C-terminus
Chlamydia trachomatis CT_472   hypothetical protein
Dictyostelium discoideum DDB_G0287989   hypothetical protein
Drosophila melanogaster Dmel_CG11679   CG11679 gene product from transcript CG11679-RA
Echinococcus granulosus EgrG_000718100   required for meiotic nuclear division protein 1
Echinococcus multilocularis EmuJ_000718100   required for meiotic nuclear division protein 1
Homo sapiens ENSG00000155906   required for meiotic nuclear division 1 homolog (S. cerevisiae)
Leishmania braziliensis LbrM.13.0930   hypothetical protein, conserved
Leishmania donovani LdBPK_131030.1   Uncharacterised ACR, YagE family COG1723, putative
Leishmania infantum LinJ.13.1030   hypothetical protein, conserved
Leishmania mexicana LmxM.13.1130   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_14233   hypothetical protein
Loa Loa (eye worm) LOAG_14991   hypothetical protein
Loa Loa (eye worm) LOAG_15279   hypothetical protein
Mus musculus 66084   required for meiotic nuclear division 1 homolog (S. cerevisiae)
Neospora caninum NCLIV_037720   Os07g0694800 protein, related
Oryza sativa 4326888   Os01g0764300
Oryza sativa 4344398   Os07g0694800
Onchocerca volvulus OVOC9484   Required for meiotic nuclear division protein 1 homolog
Plasmodium berghei PBANKA_0711300   conserved protein, unknown function
Plasmodium falciparum PF3D7_0819500   conserved protein, unknown function
Plasmodium knowlesi PKNH_1313300   conserved protein, unknown function
Plasmodium vivax PVX_089390   hypothetical protein, conserved
Plasmodium yoelii PY03075   unknown-related
Saccharomyces cerevisiae YDR282C   hypothetical protein
Saccharomyces cerevisiae YDL001W   Rmd1p
Schistosoma japonicum Sjp_0027160   similar to Uncharacterized protein YDR282C, putative
Schistosoma mansoni Smp_084860   hypothetical protein
Schmidtea mediterranea mk4.029200.00  
Schmidtea mediterranea mk4.004589.00  
Schmidtea mediterranea mk4.037186.00  
Trypanosoma brucei gambiense Tbg972.11.4230   hypothetical protein, conserved
Trypanosoma brucei Tb427tmp.02.1180   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.3700   Uncharacterised ACR, YagE family COG1723, putative, unspecified product
Trypanosoma congolense TcIL3000_0_36840   Uncharacterised ACR, YagE family COG1723, putative
Trypanosoma congolense TcIL3000.11.3650   Uncharacterised ACR, YagE family COG1723, putative
Trypanosoma cruzi TcCLB.503821.5   Uncharacterised ACR, YagE family COG1723, putative
Trypanosoma cruzi TcCLB.508731.9   Uncharacterised ACR, YagE family COG1723, putative
Trypanosoma cruzi TcCLB.509683.30   Uncharacterised ACR, YagE family COG1723, putative
Toxoplasma gondii TGME49_268630   YagE family protein

Essentiality

TcCLB.508731.9 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.1180 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.1180 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.1180 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.1180 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0711300 Plasmodium berghei Dispensable plasmo
TGME49_268630 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.508731.9 (Trypanosoma cruzi), Uncharacterised ACR, YagE family COG1723, putative
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