Detailed view for PKNH_0915400

Basic information

TDR Targets ID: 530920
Plasmodium knowlesi, GTP-binding nuclear protein RAN/TC4, putative
Source Database / ID: 

pI: 7.8781 | Length (AA): 214 | MW (Da): 24843 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0003924   GTPase activity  
GO:0006913   nucleocytoplasmic transport  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)
RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 212 3m1i (A) 10 216 71.00 0 1 1.82002 -0.91
9 204 3gj0 (B) 10 206 69.00 0.0000000031 1 1.80629 -1.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127514)

Species Accession Gene Product
Arabidopsis thaliana AT5G20010   GTP-binding nuclear protein Ran-1
Arabidopsis thaliana AT5G55190   GTP-binding nuclear protein Ran-3
Arabidopsis thaliana AT5G20020   GTP-binding nuclear protein Ran-2
Babesia bovis BBOV_IV010920   GTP-binding nuclear protein Ran
Brugia malayi Bm1_44725   GTP-binding nuclear protein RAN/TC4
Candida albicans CaO19.5493   Ran, Ras family GTP-binding protein
Candida albicans CaO19.12948   Ran, Ras family GTP-binding protein
Caenorhabditis elegans CELE_K01G5.4   Protein RAN-1
Cryptosporidium hominis Chro.70035   GTP-binding nuclear protein ran/tc4
Cryptosporidium parvum cgd7_220   GTP-binding nuclear protein ran/tc4
Dictyostelium discoideum DDB_G0291235   GTP-binding nuclear protein Ran
Drosophila melanogaster Dmel_CG1404   CG1404 gene product from transcript CG1404-RC
Echinococcus granulosus EgrG_000127100   GTP binding nuclear protein Ran
Entamoeba histolytica EHI_148190   Ran family GTPase
Echinococcus multilocularis EmuJ_000127100   GTP binding nuclear protein Ran
Giardia lamblia GL50803_15869   GTP-binding nuclear protein RAN/TC4
Homo sapiens 5901   RAN, member RAS oncogene family
Leishmania braziliensis LbrM.25.2050   GTP-binding protein, putative
Leishmania donovani LdBPK_251460.1   GTP-binding protein, putative
Leishmania infantum LinJ.25.1460   GTP-binding protein, putative
Leishmania major LmjF.25.1420   GTP-binding protein, putative
Leishmania mexicana LmxM.25.1420   GTP-binding protein, putative
Loa Loa (eye worm) LOAG_08002   GTP-binding nuclear protein RAN/TC4
Mus musculus ENSMUSG00000028287   RIKEN cDNA 1700009N14 gene
Mus musculus 102641332   GTP-binding nuclear protein Ran-like
Mus musculus ENSMUSG00000029430   RAN, member RAS oncogene family
Neospora caninum NCLIV_064310   GTP-binding nuclear protein Ran, related
Oryza sativa 4339683   Os05g0574500
Oryza sativa 4325312   Os01g0611100
Oryza sativa 9266942   Os06g0600301
Plasmodium berghei PBANKA_0930300   GTP-binding nuclear protein RAN/TC4, putative
Plasmodium falciparum PF3D7_1117700   GTP-binding nuclear protein RAN/TC4
Plasmodium knowlesi PKNH_0915400   GTP-binding nuclear protein RAN/TC4, putative
Plasmodium vivax PVX_091515   GTP-binding nuclear protein RAN/TC4, putative
Plasmodium yoelii PY04253   GTP-binding nuclear protein ran/tc4
Saccharomyces cerevisiae YLR293C   Ran GTPase GSP1
Saccharomyces cerevisiae YOR185C   Ran GTPase GSP2
Schistosoma japonicum Sjp_0071910   ko:K07936 GTP-binding nuclear protein Ran, putative
Schistosoma mansoni Smp_079430.1   ran
Schistosoma mansoni Smp_079430.2   ran
Schmidtea mediterranea mk4.001160.00   GTP-binding nuclear protein ran-1
Trypanosoma brucei gambiense Tbg972.3.830   GTP-binding nuclear protein rtb2, putative
Trypanosoma brucei Tb927.3.1120   GTP-binding nuclear protein rtb2, putative
Trypanosoma congolense TcIL3000_3_340   GTP-binding nuclear protein rtb2, putative
Trypanosoma cruzi TcCLB.509455.80   GTP-binding nuclear protein rtb2, putative
Trypanosoma cruzi TcCLB.503539.30   GTP-binding nuclear protein rtb2, putative
Toxoplasma gondii TGME49_248340   GTP-binding nuclear protein ran/tc4
Theileria parva TP01_0757   GTP-binding nuclear protein ran, putative
Trichomonas vaginalis TVAG_185080   ran, putative

Essentiality

PKNH_0915400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.1120 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.3.1120 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.1120 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.3.1120 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K01G5.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_K01G5.4 Caenorhabditis elegans larval arrest wormbase
CELE_K01G5.4 Caenorhabditis elegans larval lethal wormbase
CELE_K01G5.4 Caenorhabditis elegans sterile wormbase
YLR293C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0930300 Plasmodium berghei Essential plasmo
TGME49_248340 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens RAN, member RAS oncogene family Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PKNH_0915400 (Plasmodium knowlesi), GTP-binding nuclear protein RAN/TC4, putative
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