Detailed view for PKNH_0409500

Basic information

TDR Targets ID: 531253
Plasmodium knowlesi, tyrosine kinase-like protein, putative
Source Database / ID: 

pI: 9.3197 | Length (AA): 1036 | MW (Da): 119110 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
546 634 4q3i (A) 82 173 12.00 0.34 0.05 0.210507 -0.52
575 693 5w53 (A) 244 351 29.00 0.16 0.25 0.0750649 1.13
672 1023 3cd3 (A) 460 819 19.00 0 1 0.444768 0.82
725 963 3ofm (A) 19 233 29.00 0.000002 1 0.326895 0.92
748 1021 3ppz (A) 542 808 37.00 0 1 0.614079 -0.02
766 963 2vz6 (A) 20 213 29.00 0.00000000013 0.99 0.37032 0.48
810 963 2a2a (A) 60 217 32.00 0.00000000063 0.96 0.498849 -0.06
811 1022 3s95 (A) 381 608 31.00 0 1 0.552833 -0.2
879 973 2b9h (A) 128 235 39.00 0.00000021 0.39 0.275899 0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130251)

Species Accession Gene Product
Arabidopsis thaliana AT1G73660   MAPKKK-like kinase
Arabidopsis thaliana AT5G11850   protein kinase superfamily protein
Arabidopsis thaliana AT1G18160   protein kinase family protein
Arabidopsis thaliana AT1G08720   serine/threonine-protein kinase EDR1
Caenorhabditis elegans CELE_R13F6.6   Protein ZAK-1, isoform B
Cryptosporidium hominis Chro.80284   protein kinase
Cryptosporidium parvum cgd8_2430   Ser/Thr protein kinase with MORN repeats at the N-terminus and a sterile alpha motif (SAM_ domain
Homo sapiens ENSG00000091436   sterile alpha motif and leucine zipper containing kinase AZK
Mus musculus ENSMUSG00000004085   sterile alpha motif and leucine zipper containing kinase AZK
Neospora caninum NCLIV_015900   Protein kinase domain-containing protein (EC 2.7.11.-), related
Oryza sativa 4348694   Os10g0430900
Oryza sativa 4331696   Os03g0160100
Oryza sativa 4328754   Os02g0220700
Oryza sativa 4340578   Os06g0232100
Oryza sativa 4330701   Os02g0743500
Plasmodium berghei PBANKA_0308500   tyrosine kinase-like protein, putative
Plasmodium falciparum PF3D7_0211700   tyrosine kinase-like protein, putative
Plasmodium knowlesi PKNH_0409500   tyrosine kinase-like protein, putative
Plasmodium vivax PVX_002945   tyrosine kinase-like protein, putative
Plasmodium yoelii PY02503   MORN repeat, putative
Toxoplasma gondii TGME49_239130   Tyrosine kinase-like (TKL) protein

Essentiality

PKNH_0409500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0308500 Plasmodium berghei Dispensable plasmo
TGME49_239130 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens sterile alpha motif and leucine zipper containing kinase AZK Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PKNH_0409500 (Plasmodium knowlesi), tyrosine kinase-like protein, putative
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