Detailed view for PY05711

Basic information

TDR Targets ID: 538699
Plasmodium yoelii, tubulin beta chain
Source Database / ID: 

pI: 4.4987 | Length (AA): 445 | MW (Da): 49790 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00091   Tubulin/FtsZ family, GTPase domain
PF03953   Tubulin C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005874   microtubule  
GO:0005525   GTP binding  
GO:0005200   structural constituent of cytoskeleton  
GO:0003924   GTPase activity  
GO:0007017   microtubule-based process  

Metabolic Pathways

Phagosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 431 4i4t (D) 1 441 88.00 0 1 2.14734 -2.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126611)

Species Accession Gene Product
Arabidopsis thaliana AT5G44340   tubulin beta-4 chain
Arabidopsis thaliana AT1G75780   tubulin beta-1 chain
Arabidopsis thaliana AT2G29550   tubulin beta-7 chain
Arabidopsis thaliana AT5G12250   beta-6 tubulin
Arabidopsis thaliana AT4G20890   tubulin beta-9 chain
Arabidopsis thaliana AT5G23860   tubulin beta-8 chain
Arabidopsis thaliana AT5G62700   tubulin beta-2/beta-3 chain
Arabidopsis thaliana AT5G62690   tubulin beta-2/beta-3 chain
Arabidopsis thaliana AT1G20010   tubulin beta-5 chain
Babesia bovis BBOV_III004850   tubulin beta chain
Brugia malayi Bm1_07675   Tubulin beta-1 chain
Brugia malayi Bm1_25780   beta-tubulin, identical
Caenorhabditis elegans CELE_C54C6.2   Protein BEN-1
Caenorhabditis elegans CELE_C36E8.5   Protein TBB-2
Caenorhabditis elegans CELE_B0272.1   Protein TBB-4
Caenorhabditis elegans CELE_K01G5.7   Protein TBB-1
Caenorhabditis elegans CELE_ZK154.3   Protein MEC-7
Cryptosporidium hominis Chro.60548   beta-catenin-like repeat protein
Cryptosporidium parvum cgd6_4760   tubulin beta chain
Dictyostelium discoideum DDB_G0269196   beta tubulin
Drosophila melanogaster Dmel_CG9277   beta-Tubulin at 56D
Drosophila melanogaster Dmel_CG3401   beta-Tubulin at 60D
Drosophila melanogaster Dmel_CG4869   beta-Tubulin at 97EF
Drosophila melanogaster Dmel_CG9359   beta-Tubulin at 85D
Echinococcus granulosus EgrG_000955100   Tubulin beta 2C chain
Echinococcus granulosus EgrG_000069900   beta tubulin
Echinococcus granulosus EgrG_000617000   Tubulin beta 2C chain
Echinococcus granulosus EgrG_001126150   tubulin beta 4A class IVa
Echinococcus granulosus EgrG_000569000   tubulin subunit beta
Echinococcus granulosus EgrG_000041100   Tubulin beta 2C chain
Echinococcus granulosus EgrG_000202500   beta tubulin
Echinococcus granulosus EgrG_000202600   Tubulin beta 2C chain
Echinococcus granulosus EgrG_001081200   tubulin beta 1 chain
Echinococcus granulosus EgrG_000672200   Tubulin beta 2C chain
Entamoeba histolytica EHI_167010   tubulin family protein
Entamoeba histolytica EHI_049920   tubulin family protein
Echinococcus multilocularis EmuJ_001126150   tubulin, beta 4A class IVa
Echinococcus multilocularis EmuJ_000672200   Tubulin beta 2C chain
Echinococcus multilocularis EmuJ_000955100   Tubulin beta 2C chain
Echinococcus multilocularis EmuJ_000202500   beta tubulin
Echinococcus multilocularis EmuJ_000569000   tubulin subunit beta
Echinococcus multilocularis EmuJ_000069900   beta tubulin
Echinococcus multilocularis EmuJ_000617000   Tubulin beta 2C chain
Echinococcus multilocularis EmuJ_000202600   Tubulin beta 2C chain
Echinococcus multilocularis EmuJ_001081200   tubulin beta 1 chain
Echinococcus multilocularis EmuJ_000041100   Tubulin beta 2C chain
Giardia lamblia GL50803_101291   Beta tubulin
Giardia lamblia GL50803_136020   Beta tubulin
Giardia lamblia GL50803_136021   Beta tubulin
Homo sapiens ENSG00000137267   tubulin, beta 2A class IIa
Homo sapiens ENSG00000261456   tubulin, beta 8 class VIII
Homo sapiens ENSG00000196230   tubulin, beta class I
Homo sapiens ENSG00000104833   tubulin, beta 4A class IVa
Homo sapiens ENSG00000258947   tubulin, beta 3 class III
Homo sapiens ENSG00000258839   melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Homo sapiens ENSG00000101162   tubulin, beta 1 class VI
Homo sapiens ENSG00000188229   tubulin, beta 4B class IVb
Homo sapiens ENSG00000137285   tubulin, beta 2B class IIb
Homo sapiens ENSG00000176014   tubulin, beta 6 class V
Leishmania braziliensis LbrM.21.2150   beta tubulin
Leishmania braziliensis LbrM.33.0960   beta-tubulin
Leishmania braziliensis LbrM.33.0930   beta-tubulin
Leishmania braziliensis LbrM.33.0920   beta-tubulin
Leishmania infantum LinJ.08.1280   beta tubulin
Leishmania infantum LinJ.08.1290   beta tubulin
Leishmania infantum LinJ.21.2240   beta tubulin
Leishmania infantum LinJ.33.0860   beta-tubulin
Leishmania major LmjF.33.0816   beta tubulin
Leishmania major LmjF.33.0812   beta tubulin
Leishmania major LmjF.33.0806   beta tubulin
Leishmania major LmjF.08.1230   beta tubulin
Leishmania major LmjF.33.0804   beta tubulin
Leishmania major LmjF.33.0802   beta tubulin
Leishmania major LmjF.33.0808   beta tubulin
Leishmania major LmjF.33.0792   beta tubulin
Leishmania major LmjF.33.0819   beta tubulin
Leishmania major LmjF.33.0818   beta tubulin
Leishmania major LmjF.21.1860   beta tubulin
Leishmania major LmjF.33.0800   beta tubulin
Leishmania major LmjF.33.0814   beta tubulin
Leishmania major LmjF.33.0798   beta tubulin
Leishmania major LmjF.33.0796   beta tubulin
Leishmania major LmjF.33.0810   beta tubulin
Leishmania major LmjF.33.0794   beta tubulin
Leishmania major LmjF.33.0820   beta tubulin
Leishmania mexicana LmxM.32.0792   beta tubulin
Leishmania mexicana LmxM.21.1860   beta tubulin
Leishmania mexicana LmxM.32.0794   beta tubulin
Leishmania mexicana LmxM.08.1171  
Leishmania mexicana LmxM.08.1230   beta tubulin
Loa Loa (eye worm) LOAG_04418   tubulin beta chain
Loa Loa (eye worm) LOAG_12815   BEN-1 protein
Loa Loa (eye worm) LOAG_08711   tubulin beta-1 chain
Loa Loa (eye worm) LOAG_11824   beta-tubulin
Loa Loa (eye worm) LOAG_12555   BEN-1 protein
Loa Loa (eye worm) LOAG_00602   tubulin beta-2A chain
Loa Loa (eye worm) LOAG_10501   tubulin beta-4 chain
Mus musculus ENSMUSG00000036752   tubulin, beta 4B class IVB
Mus musculus ENSMUSG00000001525   tubulin, beta 5 class I
Mus musculus ENSMUSG00000058672   tubulin, beta 2A class IIA
Mus musculus ENSMUSG00000062591   tubulin, beta 4A class IVA
Mus musculus ensembl-mmu:ENSMUSG00000001473   tubulin, beta 6 class V
Mus musculus ENSMUSG00000045136   tubulin, beta 2B class IIB
Mus musculus 545486   tubulin, beta 1 class VI
Mus musculus ENSMUSG00000062380   tubulin, beta 3 class III
Neospora caninum NCLIV_005150   hypothetical protein
Neospora caninum NCLIV_039100   hypothetical protein
Neospora caninum NCLIV_049140   hypothetical protein
Oryza sativa 4333632   Os03g0661300
Oryza sativa 4341810   Os06g0671900
Oryza sativa 4328420   Os02g0167300
Oryza sativa 4331315   Os03g0105600
Oryza sativa 4327550   Os01g0805900
Oryza sativa 4338790   Os05g0413200
Oryza sativa 4326917   Os01g0282800
Oryza sativa 4334309   Os03g0780600
Plasmodium berghei PBANKA_1206900   tubulin beta chain, putative
Plasmodium falciparum PF3D7_1008700   tubulin beta chain
Plasmodium vivax PVX_094635   tubulin beta chain, putative
Plasmodium yoelii PY05711   tubulin beta chain
Saccharomyces cerevisiae YFL037W   beta-tubulin
Schistosoma japonicum Sjp_0027870   Tubulin beta-4 chain, putative
Schistosoma japonicum Sjp_0060500   Tubulin beta chain, putative
Schistosoma japonicum Sjp_0095680   Tubulin beta-7 chain, putative
Schistosoma japonicum Sjp_0090690   ko:K07375 tubulin beta, putative
Schistosoma japonicum Sjp_0068060   Tubulin beta chain, putative
Schistosoma japonicum Sjp_0080560   Tubulin beta-1 chain, putative
Schistosoma japonicum Sjp_0209650   Tubulin beta chain, putative
Schistosoma japonicum Sjp_0080550   Tubulin beta chain, putative
Schistosoma japonicum Sjp_0067680   Tubulin beta-1 chain, putative
Schistosoma japonicum Sjp_0090950   ko:K07375 tubulin beta, putative
Schistosoma mansoni Smp_078040   tubulin subunit beta
Schistosoma mansoni Smp_079970   tubulin subunit beta
Schistosoma mansoni Smp_192110   tubulin subunit beta
Schistosoma mansoni Smp_079960   tubulin subunit beta
Schistosoma mansoni Smp_035760   tubulin subunit beta
Schistosoma mansoni Smp_030730   tubulin subunit beta
Schmidtea mediterranea mk4.005007.03  
Schmidtea mediterranea mk4.002479.04  
Schmidtea mediterranea mk4.009333.02  
Schmidtea mediterranea mk4.004337.00  
Schmidtea mediterranea mk4.035087.00  
Schmidtea mediterranea mk4.000452.01   Tubulin beta-1 chain
Schmidtea mediterranea mk4.000225.08  
Schmidtea mediterranea mk4.005538.05   Tubulin beta-2 chain
Schmidtea mediterranea mk4.000157.13   Tubulin beta-1 chain
Schmidtea mediterranea mk4.006183.00   Tubulin beta-2 chain
Schmidtea mediterranea mk4.038724.00   Tubulin beta chain, putative
Schmidtea mediterranea mk4.000299.16   Tubulin beta-2 chain
Schmidtea mediterranea mk4.002542.01   Tubulin beta-2 chain
Schmidtea mediterranea mk4.000536.06   Tubulin beta-2 chain
Schmidtea mediterranea mk4.001487.01  
Schmidtea mediterranea mk4.055780.00   Tubulin beta chain, putative
Schmidtea mediterranea mk4.000062.06   Tubulin beta-1 chain
Schmidtea mediterranea mk4.002158.04   Tubulin beta-1 chain
Schmidtea mediterranea mk4.009683.01  
Schmidtea mediterranea mk4.001602.00  
Schmidtea mediterranea mk4.004971.01   Tubulin beta-1 chain
Schmidtea mediterranea mk4.007635.00  
Schmidtea mediterranea mk4.002409.02  
Schmidtea mediterranea mk4.000062.07   Tubulin beta-1 chain
Schmidtea mediterranea mk4.000397.07  
Trypanosoma brucei gambiense Tbg972.1.1350   beta tubulin
Trypanosoma brucei gambiense Tbg972.1.1370   beta tubulin
Trypanosoma brucei Tb927.1.2350   beta tubulin
Trypanosoma brucei Tb927.1.2330   beta tubulin
Trypanosoma brucei Tb927.1.2390   beta tubulin
Trypanosoma brucei Tb927.1.2370   beta tubulin
Trypanosoma congolense TcIL3000_0_31240   beta tubulin
Trypanosoma cruzi TcCLB.506563.40   beta tubulin, putative
Toxoplasma gondii TGME49_221620   beta-tubulin, putative
Toxoplasma gondii TGME49_266960   beta tubulin
Toxoplasma gondii TGME49_212240   beta-1 tubulin, putative
Theileria parva TP02_0464   tubulin beta chain, putative
Trichomonas vaginalis TVAG_008680   tubulin epsilon chain, putative
Trichomonas vaginalis TVAG_338530   tubulin epsilon chain, putative
Trichomonas vaginalis TVAG_525430   tubulin gamma chain, putative
Trichomonas vaginalis TVAG_456920   tubulin alpha chain, putative
Trichomonas vaginalis TVAG_062880   tubulin, putative
Trichomonas vaginalis TVAG_034440   tubulin beta chain, putative

Essentiality

PY05711 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.2330 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.1.2330 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.1.2330 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.1.2330 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C54C6.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C54C6.2 Caenorhabditis elegans larval arrest wormbase
CELE_C54C6.2 Caenorhabditis elegans slow growth wormbase
CELE_C54C6.2 Caenorhabditis elegans sterile wormbase
CELE_ZK154.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK154.3 Caenorhabditis elegans larval arrest wormbase
CELE_ZK154.3 Caenorhabditis elegans larval lethal wormbase
CELE_ZK154.3 Caenorhabditis elegans slow growth wormbase
CELE_ZK154.3 Caenorhabditis elegans sterile wormbase
CELE_K01G5.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_K01G5.7 Caenorhabditis elegans larval arrest wormbase
CELE_K01G5.7 Caenorhabditis elegans slow growth wormbase
CELE_K01G5.7 Caenorhabditis elegans sterile wormbase
CELE_C36E8.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C36E8.5 Caenorhabditis elegans larval lethal wormbase
CELE_C36E8.5 Caenorhabditis elegans slow growth wormbase
CELE_C36E8.5 Caenorhabditis elegans sterile wormbase
CELE_B0272.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0272.1 Caenorhabditis elegans slow growth wormbase
YFL037W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1206900 Plasmodium berghei Essential plasmo
TGME49_212240 Toxoplasma gondii Probably non-essential sidik
TGME49_266960 Toxoplasma gondii Probably non-essential sidik
TGME49_221620 Toxoplasma gondii Probably non-essential sidik
TGME49_212240 Toxoplasma gondii Probably essential sidik
TGME49_266960 Toxoplasma gondii Probably essential sidik
TGME49_221620 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major beta tubulin Compounds References
Homo sapiens tubulin, beta 6 class V Compounds References
Leishmania major beta tubulin Compounds References
Leishmania major beta tubulin Compounds References
Leishmania major beta tubulin Compounds References
Plasmodium falciparum tubulin beta chain Compounds References
Leishmania major beta tubulin Compounds References
Homo sapiens tubulin, beta 2B class IIb Compounds References
Leishmania major beta tubulin Compounds References
Leishmania major beta tubulin Compounds References
Leishmania major beta tubulin Compounds References
Homo sapiens tubulin, beta 2A class IIa Compounds References
Homo sapiens tubulin, beta 8 class VIII Compounds References
Leishmania major beta tubulin Compounds References
Homo sapiens tubulin, beta 4B class IVb Compounds References
Leishmania major beta tubulin Compounds References
Bos taurus Tubulin beta chain Compounds References
Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Compounds References
Leishmania major beta tubulin Compounds References
Leishmania donovani Beta tubulin Compounds References
Homo sapiens tubulin, beta 4A class IVa Compounds References
Homo sapiens tubulin, beta 1 class VI Compounds References
Trypanosoma brucei beta tubulin Compounds References
Leishmania major beta tubulin Compounds References
Leishmania major beta tubulin Compounds References
Leishmania major beta tubulin Compounds References
Leishmania major beta tubulin Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Tubulin 85 aa 51.2% 80 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PY05711 (Plasmodium yoelii), tubulin beta chain
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