Detailed view for TcCLB.506801.80

Basic information

TDR Targets ID: 54350
Trypanosoma cruzi, cysteine peptidase inhibitor
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.0727 | Length (AA): 110 | MW (Da): 12034 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09394   Chagasin family peptidase inhibitor I42

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 110 2fo8 (A) 3 110 96.00 0 1 2.06 -0.43
3 110 2h7w (A) 3 110 97.00 0 1 2.16472 -1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2FO8:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2H7W:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2NNR:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2NQD:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2OUL:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3CBJ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3CBK:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3E1Z:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_136685)

Species Accession Gene Product
Cryptosporidium hominis Chro.60226   transmembrane protein
Cryptosporidium parvum cgd6_1910   conserved hypothetical protein
Entamoeba histolytica EHI_159600   cysteine protease inhibitor 1 (EhICP1)
Entamoeba histolytica EHI_040460   cysteine protease inhibitor 2 (EhICP2)
Leishmania braziliensis LbrM.24.1840   inhibitor of cysteine peptidase
Leishmania donovani LdBPK_241840.1   inhibitor of cysteine peptidase
Leishmania infantum LinJ.24.1840   inhibitor of cysteine peptidase
Leishmania major LmjF.24.1770   inhibitor of cysteine peptidase
Leishmania mexicana LmxM.24.1770   inhibitor of cysteine peptidase
Trypanosoma brucei gambiense Tbg972.8.6530   inhibitor of cysteine peptidase, putative,ICP, putative
Trypanosoma brucei Tb927.8.6450   inhibitor of cysteine peptidase
Trypanosoma cruzi TcCLB.506801.80   cysteine peptidase inhibitor
Trypanosoma cruzi TcCLB.511907.200   cysteine peptidase inhibitor, putative

Essentiality

TcCLB.506801.80 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.6450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.6450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.6450 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.6450 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major inhibitor of cysteine peptidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0512 0.256 0.2549
0.0232 0.2546 0.2543
0.0536 0.256 0.2549
0.0277 0.2579 0.2579
0.0265 0.2549 0.2643
0.0274 0.2646 0.2643
0.054 0.256 0.2549
0.0254 0.2519 0.2517
0.0252 0.2519 0.2517
0.0564 0.2578 0.256
0.0255 0.2613 0.2613
0.0512 0.256 0.2549
0.0234 0.2594 0.2594
0.0569 0.256 0.2549
0.0244 0.2681 0.2673
0.028 0.2646 0.2643
0.0508 0.256 0.2549
0.0256 0.269 0.2673
0.0231 0.2681 0.2673
0.0282 0.2697 0.2692
0.0508 0.256 0.2549
0.024 0.2579 0.2579
0.054 0.256 0.2549
0.0564 0.256 0.2549
0.0564 0.2549 0.2549
0.0236 0.2579 0.2579
0.0181 0.2582 0.2582
0.0251 0.2594 0.2594
0.0265 0.2649 0.2683
0.0265 0.2592 0.2643
0.0275 0.269 0.2673
0.0234 0.2594 0.2594
0.0243 0.2594 0.2594
0.0569 0.256 0.2549
0.0255 0.2512 0.2527
0.0183 0.2741 0.2736
0.0536 0.256 0.2549
0.0536 0.256 0.2549
0.023 0.2646 0.2643
0.0277 0.2646 0.2643
0.0231 0.2681 0.2673
0.0353971 0.305248 0.305248
0.0256 0.2594 0.2594
0.0580982 0.331185 0.32461
0.0282 0.252 0.2517
0.0266 0.2594 0.2594
0.0272 0.2646 0.2643
0.0233 0.2514 0.2514
0.023 0.2681 0.2673
0.0536 0.256 0.2549
0.0234 0.2594 0.2594
0.0277 0.2695 0.2692
0.0246 0.269 0.2673
0.0181 0.2561 0.2549
0.0235 0.2594 0.2594
0.0274 0.2646 0.2643
0.0227 0.2594 0.2594
0.0277 0.2695 0.2692
0.0484 0.256 0.2549
0.0242 0.2673 0.2673
0.0272 0.2645 0.2643
0.0256 0.2579 0.2579
0.0234 0.2594 0.2594
0.0282 0.2641 0.2579
0.0238 0.269 0.2673
0.0282 0.2697 0.2692
0.0512 0.256 0.2549
0.0255 0.2613 0.2613
0.0564 0.2578 0.256
0.024 0.251 0.2482
0.0261 0.2579 0.2579
0.0251 0.2594 0.2594
0.0236 0.26 0.2594
0.0277 0.2579 0.2579
0.0249 0.2512 0.2517
0.0265 0.2592 0.2643
0.0682114 0.331076 0.32461
0.0256 0.2629 0.2643
0.0564 0.256 0.2549
0.0128 0.2549 0.2549
0.0233 0.2508 0.2503
0.0571 0.2578 0.256
0.054 0.256 0.2549
0.0255 0.2613 0.2613
0.0229 0.2594 0.2594
0.0229 0.2519 0.2518
0.0256 0.2579 0.2579
0.023 0.2646 0.2643
0.0241 0.2579 0.2579
0.0229 0.26 0.2594
0.0263 0.2511 0.2482
0.0229 0.26 0.2594
0.0274 0.2579 0.2579
0.023 0.2594 0.2594
0.024 0.2579 0.2579
0.0248 0.251 0.2482
0.0255 0.2542 0.2514
0.0277 0.2695 0.2692
0.0569 0.256 0.2549
0.0226 0.2594 0.2594
0.027 0.258 0.2526
0.0181 0.2582 0.2582
0.0276 0.2594 0.2594
0.0279 0.2595 0.2594
0.0408 0.256 0.2549
0.0243 0.2579 0.2579
0.0262 0.269 0.2674
0.0580982 0.331185 0.32461
0.0271 0.2594 0.2594
0.0256 0.2549 0.2549
0.024 0.269 0.2673
0.0235 0.269 0.2673
0.0227 0.2675 0.2643
0.028 0.2646 0.2643
0.0277 0.2579 0.2579
0.0247 0.2579 0.2579
0.0243 0.2594 0.2594
0.0233 0.2508 0.2503
0.0244 0.2514 0.2514
0.0282 0.2697 0.2692
0.0261 0.2612 0.2612
0.0484 0.256 0.2549

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

12 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.506801.80 (Trypanosoma cruzi), cysteine peptidase inhibitor
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