Detailed view for TcCLB.507491.151

Basic information

TDR Targets ID: 54844
Trypanosoma cruzi, flagellar calcium-binding 24 kDa protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.6691 | Length (AA): 211 | MW (Da): 23728 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13202   EF hand
PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0009288   flagellin-based flagellum  
GO:0005509   calcium ion binding  
GO:0001539   ciliary or flagellar motility  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
35 211 1uhk (A) 1 187 16.00 0 1 0.95 -0.27
126 196 1zmz (A) 27 96 30.00 0.000000014 0.96 0.89 -1.85
17 208 3cs1 (A) 17 208 97.00 0 1 2.23865 -2.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3CS1:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133600)

Species Accession Gene Product
Leishmania braziliensis LbrM.16.0930   flagellar calcium-binding protein, putative
Leishmania donovani LdBPK_160930.1   flagellar calcium-binding protein, putative
Leishmania infantum LinJ.16.0930   flagellar calcium-binding protein, putative
Leishmania mexicana LmxM.16.0910   flagellar calcium-binding protein, putative
Leishmania mexicana LmxM.16.0920   flagellar calcium-binding protein, putative
Trypanosoma brucei gambiense Tbg972.8.5410   flagellar calcium-binding protein TB-24, putative
Trypanosoma brucei gambiense Tbg972.8.5430   flagellar calcium-binding protein Tb-17
Trypanosoma brucei Tb927.8.5460   Flagellar calcium-binding 44 kDa protein
Trypanosoma brucei Tb427.08.5465   24 kDa calcimedin
Trypanosoma brucei Tb11.v5.0798   flagellar calcium-binding protein
Trypanosoma brucei Tb11.v5.0797   flagellar calcium-binding protein
Trypanosoma brucei Tb927.8.5440   flagellar calcium-binding 24 kDa protein
Trypanosoma brucei Tb927.8.5470   flagellar calcium-binding 24 kDa protein
Trypanosoma congolense TcIL3000_0_43830   Flagellar calcium-binding protein 17, putative
Trypanosoma congolense TcIL3000_0_43820   Flagellar calcium-binding protein 24, putative
Trypanosoma congolense TcIL3000_8_5250   Flagellar calcium-binding protein 24, putative
Trypanosoma cruzi TcCLB.506749.20   flagellar calcium-binding 24 kDa protein
Trypanosoma cruzi TcCLB.509391.30   flagellar calcium-binding 24 kDa protein
Trypanosoma cruzi TcCLB.507891.38   flagellar calcium-binding 24 kDa protein
Trypanosoma cruzi TcCLB.507491.151   flagellar calcium-binding 24 kDa protein
Trypanosoma cruzi TcCLB.509391.10   flagellar calcium-binding 24 kDa protein
Trypanosoma cruzi TcCLB.507891.47   flagellar calcium-binding 24 kDa protein
Trypanosoma cruzi TcCLB.507891.29   flagellar calcium-binding 24 kDa protein
Trypanosoma cruzi TcCLB.509391.20   flagellar calcium-binding 24 kDa protein

Essentiality

TcCLB.507491.151 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.5460 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.5460 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.5460 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.5460 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.5440 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.5440 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.5440 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.5440 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.5470 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.5470 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.5470 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.5470 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Calmodulin 149 aa 23.9% 163 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.507491.151 (Trypanosoma cruzi), flagellar calcium-binding 24 kDa protein
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