pI: 9.7191 |
Length (AA): 1321 |
MW (Da): 158748 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
352 | 1308 | 5czz (A) | 60 | 972 | 21.00 | 0.11 | 1 | 0.587651 | 2.19 |
641 | 923 | 4gf2 (A) | 356 | 718 | 29.00 | 0.058 | 0.17 | 0.0514316 | 0.62 |
643 | 932 | 4hte (A) | 274 | 593 | 24.00 | 0.11 | 0.08 | 0.350731 | 0.09 |
1016 | 1197 | 4uos (A) | 6 | 184 | 20.00 | 0.27 | 0.48 | 0.325074 | -0.4 |
352 | 1308 | 5czz (A) | 60 | 972 | 21.00 | 0.094 | 1 | 0.600751 | 2.07 |
605 | 963 | 4wat (A) | 160 | 494 | 30.00 | 0.093 | 0.02 | 0.236064 | 0.71 |
643 | 915 | 4hte (A) | 274 | 583 | 26.00 | 0.36 | 0.13 | 0.341962 | 0.01 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | gametocyte, Female Gametocyte. | PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Ring, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Sporozoite. | Otto TD Zanghi G |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_127158)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G48760 | putative S-acyltransferase |
Arabidopsis thaliana | AT5G41060 | DHHC-type zinc finger family protein |
Arabidopsis thaliana | AT3G26935 | putative S-acyltransferase |
Arabidopsis thaliana | AT4G24630 | DHHC-type zinc finger family protein |
Arabidopsis thaliana | AT5G50020 | putative S-acyltransferase |
Babesia bovis | BBOV_II002930 | DHHC zinc finger domain containing protein |
Candida albicans | CaO19.4466 | protein involved in palmitoylation and localization of RAS2 |
Candida albicans | CaO19.11947 | similar to ERF2: RAS2p palmitoylation and localization |
Candida albicans | CaO19.11946 | protein involved in palmitoylation and localization of RAS2 |
Caenorhabditis elegans | CELE_Y47H9C.2 | Protein DHHC-2 |
Cryptosporidium hominis | Chro.70184 | hypothetical protein |
Cryptosporidium parvum | cgd7_1560 | DHHC family palmitoyl transferase with a signal peptide and 4 transmembrane domains |
Dictyostelium discoideum | DDB_G0276997 | DHHC-type zinc finger-containing protein |
Dictyostelium discoideum | DDB_G0284603 | hypothetical protein |
Drosophila melanogaster | Dmel_CG42318 | approximated |
Echinococcus granulosus | EgrG_000160400 | palmitoyltransferase zdhhc9 |
Echinococcus granulosus | EgrG_002010500 | palmitoyltransferase ZDHHC14 |
Entamoeba histolytica | EHI_198560 | hypothetical protein, conserved domain containing |
Echinococcus multilocularis | EmuJ_000160000 | palmitoyltransferase ZDHHC14 |
Echinococcus multilocularis | EmuJ_000160400 | palmitoyltransferase zdhhc9 |
Echinococcus multilocularis | EmuJ_000161000 | palmitoyltransferase ZDHHC14 |
Giardia lamblia | GL50803_6733 | Zinc finger domain |
Giardia lamblia | GL50803_8619 | Zinc finger domain |
Homo sapiens | ENSG00000175048 | zinc finger, DHHC-type containing 14 |
Homo sapiens | ENSG00000188706 | zinc finger, DHHC-type containing 9 |
Leishmania braziliensis | LbrM.25.1870 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_252390.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.25.2390 | hypothetical protein, conserved |
Leishmania major | LmjF.25.2280 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.25.2280 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000034265 | zinc finger, DHHC domain containing 14 |
Mus musculus | ENSMUSG00000036985 | zinc finger, DHHC domain containing 9 |
Neospora caninum | NCLIV_069490 | hypothetical protein |
Oryza sativa | 4326900 | Os01g0279000 |
Oryza sativa | 4346154 | Os08g0535400 |
Oryza sativa | 4325051 | Os01g0868200 |
Oryza sativa | 4347526 | Os09g0508300 |
Oryza sativa | 4338902 | Os05g0436900 |
Oryza sativa | 4327233 | Os01g0925300 |
Oryza sativa | 4346178 | Os08g0539100 |
Plasmodium berghei | PBANKA_1420900 | palmitoyltransferase DHHC4, putative |
Plasmodium falciparum | PF3D7_0714300 | palmitoyltransferase DHHC4, putative |
Plasmodium knowlesi | PKNH_1423200 | palmitoyltransferase DHHC4, putative |
Plasmodium vivax | PVX_122945 | palmitoyltransferase, putative |
Plasmodium yoelii | PY02619 | unknown protein |
Saccharomyces cerevisiae | YLR246W | Erf2p |
Schistosoma japonicum | Sjp_0061890 | Probable palmitoyltransferase ZDHHC8, putative |
Schistosoma japonicum | Sjp_0023850 | Probable palmitoyltransferase ZDHHC5, putative |
Schistosoma mansoni | Smp_073070 | hypothetical protein |
Schistosoma mansoni | Smp_146700 | zinc finger protein |
Schmidtea mediterranea | mk4.005341.00 | Palmitoyltransferase |
Schmidtea mediterranea | mk4.002530.02 | |
Schmidtea mediterranea | mk4.003021.01 | Palmitoyltransferase |
Trypanosoma brucei gambiense | Tbg972.3.2380 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.3.2400 | palmitoyl acyltransferase 10, putative |
Trypanosoma congolense | TcIL3000_3_1430 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508479.200 | palmitoyl acyltransferase 10, putative |
Toxoplasma gondii | TGME49_213550 | DHHC zinc finger domain-containing protein |
Theileria parva | TP01_0341 | hypothetical protein, conserved |
Theileria parva | TP03_0623 | hypothetical protein |
Theileria parva | TP04_0300 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.2400 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.2400 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.2400 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.2400 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1420900 | Plasmodium berghei | Essential | plasmo |
TGME49_213550 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1