Detailed view for EgrG_000476800

Basic information

TDR Targets ID: 575494
Echinococcus granulosus, cell division protein
Source Database / ID:  GeneDB

pI: 4.8955 | Length (AA): 332 | MW (Da): 36375 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01728   FtsJ-like methyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008175   tRNA methyltransferase activity  
GO:0008168   methyltransferase activity  
GO:0032259   methylation  
GO:0008033   tRNA processing  
GO:0001510   RNA methylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 210 2nyu (A) 2 189 33.00 0 1 0.952889 -0.81
21 211 3dou (A) 18 197 30.00 0 1 0.815901 -0.51
21 210 2plw (A) 2 198 27.00 0 0.87 0.765889 -0.27
118 191 5x89 (A) 151 227 37.00 0.43 0.16 0.288692 2.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127766)

Species Accession Gene Product
Babesia bovis BBOV_IV009410   rRNA methyltransferase, putative
Brugia malayi Bm1_44340   protein R74.7
Candida albicans CaO19.14043   likely methyltransferase similar to S. cerevisiae TRM7 (YBR061C) cytoplasmic tRNA methyltransferase
Candida albicans CaO19.6751   likely methyltransferase similar to S. cerevisiae TRM7 (YBR061C) cytoplasmic tRNA methyltransferase
Caenorhabditis elegans CELE_R74.7   Protein R74.7
Cryptosporidium hominis Chro.30118   cell division protein
Cryptosporidium parvum cgd3_890   ybr061c-like, FtsJ methylase
Dictyostelium discoideum DDB_G0280483   rRNA -methyltransferase
Drosophila melanogaster Dmel_CG7009   CG7009 gene product from transcript CG7009-RA
Drosophila melanogaster Dmel_CG5220   CG5220 gene product from transcript CG5220-RA
Echinococcus granulosus EgrG_000476800   cell division protein
Echinococcus granulosus EgrG_000476700   phosphatidylinositol glycan biosynthesis class s
Entamoeba histolytica EHI_098730   ribosomal RNA methyltransferase, putative
Echinococcus multilocularis EmuJ_000476700   phosphatidylinositol glycan biosynthesis class s
Echinococcus multilocularis EmuJ_000476800   cell division protein
Giardia lamblia GL50803_6055   FtsJ-like protein
Homo sapiens ENSG00000068438   FtsJ RNA methyltransferase homolog 1 (E. coli)
Leishmania braziliensis LbrM.02.0410   FtsJ-like methyltransferase, putative
Leishmania donovani LdBPK_020350.1   FtsJ-like methyltransferase, putative
Leishmania infantum LinJ.02.0350   FtsJ-like methyltransferase, putative
Leishmania major LmjF.02.0380   FtsJ-like methyltransferase, putative
Leishmania mexicana LmxM.02.0380   FtsJ-like methyltransferase, putative
Loa Loa (eye worm) LOAG_05470   hypothetical protein
Mus musculus ensembl-mmu:ENSMUSG00000031171   FtsJ homolog 1 (E. coli)
Neospora caninum NCLIV_024280   KLLA0F18414p, related
Oryza sativa 4342000   Os06g0704900
Plasmodium berghei PBANKA_0809800   ribosomal RNA methyltransferase, putative
Plasmodium falciparum PF3D7_0908600   ribosomal RNA methyltransferase, putative
Plasmodium knowlesi PKNH_0706600   ribosomal RNA methyltransferase, putative
Plasmodium vivax PVX_098870   ribosomal RNA methyltransferase, putative
Plasmodium yoelii PY05388   putative cell division protein
Saccharomyces cerevisiae YBR061C   Trm7p
Schistosoma japonicum Sjp_0308520   Putative ribosomal RNA methyltransferase CG5220, putative
Schistosoma japonicum Sjp_0096420   IPR000777,Envelope glycoprotein GP120,domain-containing
Schistosoma japonicum Sjp_0218110   ko:K02427 cell division protein methyltransferase FtsJ, putative
Schistosoma mansoni Smp_137590   ribosomal RNA methyltransferase
Schmidtea mediterranea mk4.000825.05   Putative tRNA
Trypanosoma brucei gambiense Tbg.972.2.1010   ribosomal RNA methyltransferase, putative
Trypanosoma brucei Tb927.2.2450   ribosomal RNA methyltransferase, putative
Trypanosoma congolense TcIL3000_0_50270   ribosomal RNA methyltransferase, putative
Trypanosoma cruzi TcCLB.508741.290   ribosomal RNA methyltransferase, putative
Toxoplasma gondii TGME49_263670   ribosomal RNA large subunit methyltransferase FTSJ1, putative
Theileria parva TP01_0830   hypothetical protein
Trichomonas vaginalis TVAG_092500   ribosomal RNA methyltransferase, putative
Trichomonas vaginalis TVAG_319930   ribosomal RNA methyltransferase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0577   23S rRNA methylase

Essentiality

EgrG_000476800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.2450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.2450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.2450 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.2450 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_263670 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000476800 (Echinococcus granulosus), cell division protein
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