Detailed view for EgrG_000144700

Basic information

TDR Targets ID: 577513
Echinococcus granulosus, echinoderm microtubule associated protein1
Source Database / ID:  GeneDB

pI: 5.5889 | Length (AA): 679 | MW (Da): 74623 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat
PF03451   HELP motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 678 4ci8 (A) 189 815 52.00 0 1 1.59903 -0.71
491 563 2hes (X) 104 180 27.00 0.0037 1 0.554011 -0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129133)

Species Accession Gene Product
Brugia malayi Bm1_14480   HELP domain containing protein
Caenorhabditis elegans CELE_F38A6.2   Protein ELP-1, isoform B
Drosophila melanogaster Dmel_CG42247   Doublecortin-domain-containing echinoderm-microtubule-associated protein ortholog
Echinococcus granulosus EgrG_000144700   echinoderm microtubule associated protein1
Echinococcus granulosus EgrG_002071300   echinoderm microtubule associated protein
Echinococcus multilocularis EmuJ_000139600   echinoderm microtubule associated protein
Echinococcus multilocularis EmuJ_000144700   echinoderm microtubule associated protein1
Homo sapiens ENSG00000066629   echinoderm microtubule associated protein like 1
Homo sapiens ENSG00000149499   echinoderm microtubule associated protein like 3
Homo sapiens ENSG00000143924   echinoderm microtubule associated protein like 4
Homo sapiens ENSG00000125746   echinoderm microtubule associated protein like 2
Loa Loa (eye worm) LOAG_07893   hypothetical protein
Mus musculus ENSMUSG00000058070   echinoderm microtubule associated protein like 1
Mus musculus ENSMUSG00000040811   echinoderm microtubule associated protein like 2
Mus musculus ENSMUSG00000032624   echinoderm microtubule associated protein like 4
Mus musculus ENSMUSG00000071647   echinoderm microtubule associated protein like 3
Schistosoma japonicum Sjp_0050030   expressed protein
Schistosoma japonicum Sjp_0096250   similar to 77 kDa echinoderm microtubule-associated protein, putative
Schistosoma japonicum Sjp_0091140   Echinoderm microtubule-associated protein-like 1, putative
Schistosoma mansoni Smp_163210   hypothetical protein
Schmidtea mediterranea mk4.000552.08   Echinoderm microtubule-associated protein-like CG42247
Schmidtea mediterranea mk4.002323.04   Echinoderm microtubule-associated protein-like elp-1
Schmidtea mediterranea mk4.000292.10   Echinoderm microtubule-associated protein-like elp-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens echinoderm microtubule associated protein like 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.009 1 1
0.0314 0.2515 1
0.0241 0.2567 1
0.009 1 1
0.0306 0.3008 0.301
0.0314 0.2515 1
0.0314 0.2515 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000144700 (Echinococcus granulosus), echinoderm microtubule associated protein1
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