Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.8564 | 1 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0074 | 0.7039 | 0.0855 |
Trypanosoma brucei | Casein kinase II | 0.0082 | 0.8564 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0082 | 0.8564 | 1 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0074 | 0.7039 | 0.0855 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.8564 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0082 | 0.8564 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0072 | 0.6762 | 0.5528 |
Schistosoma mansoni | protein kinase | 0.0082 | 0.8564 | 0.5152 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0082 | 0.8564 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.8564 | 1 |
Plasmodium vivax | unspecified product | 0.0082 | 0.8564 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.8564 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0082 | 0.8564 | 0.5567 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.8564 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 0.8564 | 0.5 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0074 | 0.7039 | 0.5911 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.8564 | 1 |
Echinococcus granulosus | echinoderm microtubule associated protein1 | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0082 | 0.8564 | 0.5567 |
Brugia malayi | Protein kinase domain containing protein | 0.0074 | 0.7039 | 0.7039 |
Echinococcus multilocularis | echinoderm microtubule associated protein | 0.009 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.009 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0082 | 0.8564 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0082 | 0.8564 | 0.8018 |
Brugia malayi | Casein kinase II, alpha chain | 0.0082 | 0.8564 | 0.8564 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0082 | 0.8564 | 1 |
Echinococcus multilocularis | echinoderm microtubule associated protein1 | 0.009 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0082 | 0.8564 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.8564 | 1 |
Leishmania major | casein kinase II, putative | 0.0082 | 0.8564 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0 % | Inhibition of wild type EML4-ALK (unknown origin) expressed in mouse Ba/F3 cells assessed as cell viability at 1 uM after 72 hrs by MTS assay | ChEMBL. | 26568289 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.