pI: 7.0448 |
Length (AA): 263 |
MW (Da): 28100 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 111 | 2vrn (A) | 11 | 135 | 14.00 | 0.08 | 0.21 | 0.436542 | -0.39 |
8 | 213 | 4gud (A) | 5 | 190 | 19.00 | 0.000000016 | 0.78 | 0.87077 | 0.34 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126858)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G37150 | holocarboxylase synthetase 2 |
Arabidopsis thaliana | AT2G25710 | holocarboxylase synthase 1 |
Brugia malayi | Bm1_15240 | biotin--acetyl-CoA-carboxylase ligase family protein |
Candida albicans | CaO19.7645 | Biotin:apoprotein ligase |
Caenorhabditis elegans | CELE_F13H8.10 | Protein BPL-1, isoform C |
Cryptosporidium hominis | Chro.20303 | transcriptional repressor of the biotin operon birA |
Cryptosporidium parvum | cgd2_2890 | putative biotin-(acetyl-CoA carboxylase) ligase |
Chlamydia trachomatis | CT_035 | hypothetical protein |
Chlamydia trachomatis | CT_725 | biotin synthetase |
Dictyostelium discoideum | DDB_G0289035 | biotin--[acetyl-CoA-carboxylase] ligase 3 |
Dictyostelium discoideum | DDB_G0288789 | biotin--[acetyl-CoA-carboxylase] ligase 2 |
Dictyostelium discoideum | DDB_G0288791 | biotin--[acetyl-CoA-carboxylase] ligase 1 |
Drosophila melanogaster | Dmel_CG14670 | Holocarboxylase synthetase |
Escherichia coli | b3973 | bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/DNA-binding transcriptional repressor, bio-5'-AMP-binding |
Echinococcus granulosus | EgrG_000518400 | 5'partial|biotin protein ligase |
Echinococcus granulosus | EgrG_000685000 | N terminal of biotin protein ligase |
Entamoeba histolytica | EHI_104900 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_167730 | biotin--acetyl-CoA-carboxylase ligase, putative |
Entamoeba histolytica | EHI_193800 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_033910 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_011260 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_101430 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_193790 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_104890 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_177040 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_101420 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000518400 | biotin protein ligase |
Echinococcus multilocularis | EmuJ_000685000 | N terminal of biotin protein ligase |
Echinococcus multilocularis | EmuJ_000518600 | biotin protein ligase |
Giardia lamblia | GL50803_12082 | Hypothetical protein |
Homo sapiens | ENSG00000159267 | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) |
Leishmania braziliensis | LbrM.31.1280 | biotin/lipoate protein ligase-like protein |
Leishmania donovani | LdBPK_311070.1 | biotin/lipoate protein ligase-like protein |
Leishmania infantum | LinJ.31.1070 | biotin/lipoate protein ligase-like protein |
Leishmania major | LmjF.31.1070 | biotin/lipoate protein ligase-like protein |
Leishmania mexicana | LmxM.30.1070 | biotin/lipoate protein ligase-like protein |
Loa Loa (eye worm) | LOAG_11686 | biotin protein ligase 1 |
Loa Loa (eye worm) | LOAG_15956 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10903 | hypothetical protein |
Mycobacterium leprae | ML0732 | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS |
Mus musculus | ENSMUSG00000040820 | holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) |
Mycobacterium tuberculosis | Rv3279c | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas |
Mycobacterium ulcerans | MUL_2631 | bifunctional protein BirA |
Oryza sativa | 4328417 | Os02g0167000 |
Plasmodium berghei | PBANKA_1323600 | biotin protein ligase, putative |
Plasmodium berghei | PBANKA_0511000 | biotin--acetyl-CoA-carboxylase, putative |
Plasmodium falciparum | PF3D7_1460000 | biotin protein ligase, putative |
Plasmodium falciparum | PF3D7_1026900 | biotin--acetyl-CoA-carboxylase, putative |
Plasmodium knowlesi | PKNH_0611300 | Biotin--acetyl-CoA-carboxylase ligase, putative |
Plasmodium vivax | PVX_111375 | biotin--[acetyl-CoA-carboxylase] synthetase, putative |
Plasmodium yoelii | PY06060 | biotin--acetyl-CoA-carboxylase ligase |
Plasmodium yoelii | PY01917 | biotin--acetyl-CoA-carboxylase ligase |
Saccharomyces cerevisiae | YDL141W | biotin--[acetyl-CoA-carboxylase] ligase BPL1 |
Schistosoma japonicum | Sjp_0021510 | ko:K01942 biotin-[methylmalonyl-CoA-carboxyltransferase] ligase [EC6.3.4.9], putative |
Schistosoma japonicum | Sjp_0309010 | expressed protein |
Schistosoma japonicum | Sjp_0021920 | ko:K01942 biotin-[methylmalonyl-CoA-carboxyltransferase] ligase [EC6.3.4.9], putative |
Schistosoma mansoni | Smp_081420 | biotin-protein ligase |
Schistosoma mansoni | Smp_153150 | biotin-protein ligase |
Schmidtea mediterranea | mk4.000351.05 | BiotinALQ-protein ligase |
Trypanosoma brucei gambiense | Tbg972.11.11300 | Biotin--acetyl-CoA-carboxylase ligase, putative,biotin--protein ligase, putative |
Trypanosoma brucei | Tb927.11.10060 | Biotin--acetyl-CoA-carboxylase ligase, putative |
Trypanosoma congolense | TcIL3000.11.10550 | Biotin--acetyl-CoA-carboxylase ligase, putative |
Trypanosoma congolense | TcIL3000_0_32190 | Biotin--acetyl-CoA-carboxylase ligase, putative |
Trypanosoma cruzi | TcCLB.510719.60 | Biotin--acetyl-CoA-carboxylase ligase, putative |
Trypanosoma cruzi | TcCLB.509749.10 | Biotin--acetyl-CoA-carboxylase ligase, putative |
Treponema pallidum | TP0357 | biotin--acetyl-CoA-carboxylase ligase |
Wolbachia endosymbiont of Brugia malayi | Wbm0620 | biotin-(acetyl-CoA carboxylase) ligase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.1820 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.1820 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.1820 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.1820 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3973 | Escherichia coli | essential | goodall |
YDL141W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0511000 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_1323600 | Plasmodium berghei | Dispensable | plasmo |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | BirA bifunctional protein | Compounds | References |
Escherichia coli | bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/DNA-binding transcriptional repressor, bio-5'-AMP-binding | Compounds | References |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Biotin--acetyl-CoA-carboxylase ligase | Compounds | References |
Staphylococcus aureus | Bifunctional ligase/repressor BirA | Compounds | References |
Mycobacterium tuberculosis | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas | Compounds | References |
Homo sapiens | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | Compounds | References |