Detailed information for compound 1706881

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.695 | Formula: C30H44N4O4
  • H donors: 1 H acceptors: 4 LogP: 5.13 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@H]1CN(CCCC[C@H]2CNC(=O)C(=O)N2Cc2ccccc2)C(=O)C(=O)N1CC1CCCCC1)C
  • InChi: 1S/C30H44N4O4/c1-22(2)17-26-21-32(29(37)30(38)34(26)20-24-13-7-4-8-14-24)16-10-9-15-25-18-31-27(35)28(36)33(25)19-23-11-5-3-6-12-23/h3,5-6,11-12,22,24-26H,4,7-10,13-21H2,1-2H3,(H,31,35)/t25-,26-/m0/s1
  • InChiKey: XEQUOQNABFHQHY-UIOOFZCWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin Z-like cysteine proteinase 0.0097 0.0136 0.0634
Onchocerca volvulus Cathepsin L homolog 0.0097 0.0136 0.1269
Echinococcus multilocularis biotin protein ligase 0.1084 0.2149 0.3147
Echinococcus granulosus transient receptor potential cation channel 0.3373 0.6822 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0032 0.0046
Loa Loa (eye worm) RNA binding protein 0.0074 0.0088 0.0411
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.0136 0.0634
Onchocerca volvulus Lipoyltransferase 1, mitochondrial homolog 0.0314 0.0579 0.567
Loa Loa (eye worm) hypothetical protein 0.0097 0.0136 0.0634
Brugia malayi RNA binding protein 0.0074 0.0088 0.0411
Trypanosoma cruzi cruzipain precursor, putative 0.0528 0.1015 0.4642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0272 0.0492 0.4054
Leishmania major cathepsin L-like protease 0.0528 0.1015 0.4642
Echinococcus granulosus cathepsin l cysteine peptidase 0.0528 0.1015 0.1487
Echinococcus multilocularis cathepsin L cysteine protease 0.0528 0.1015 0.1486
Schistosoma mansoni cathepsin C 0.0097 0.0136 0.0201
Echinococcus multilocularis transient receptor potential cation channel 0.0031 0.000000074588 0.00000010923
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0097 0.0136 0.0597
Schistosoma mansoni cathepsin F (C01 family) 0.0353 0.0658 0.0973
Entamoeba histolytica hypothetical protein, conserved 0.0708 0.1383 0.4666
Plasmodium falciparum serine repeat antigen 7 0.0097 0.0136 0.0494
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0097 0.0136 0.0597
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.1015 1
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.0136 0.0634
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0097 0.0136 0.0201
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0097 0.0136 0.0494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.0492 0.2176
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0097 0.0136 0.0494
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Echinococcus multilocularis cathepsin b 0.0097 0.0136 0.02
Plasmodium vivax unspecified product 0.0097 0.0136 0.0597
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0272 0.0492 0.0728
Brugia malayi Pre-SET motif family protein 0.0035 0.0009 0.004
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.0136 0.0634
Schistosoma mansoni lipoate-protein ligase B 0.0314 0.0579 0.0856
Trichomonas vaginalis set domain proteins, putative 0.0276 0.0501 0.4158
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0136 0.0201
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0097 0.0136 0.0597
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0528 0.1015 0.4721
Trypanosoma brucei lipoyltransferase, putative 0.0314 0.0579 0.2585
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0009 0.0013
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Echinococcus multilocularis cathepsin L 0.0097 0.0136 0.02
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0272 0.0492 0.2176
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Entamoeba histolytica cysteine protease, putative 0.0097 0.0136 0.0432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0658 0.5946
Entamoeba histolytica hypothetical protein, conserved 0.1477 0.2953 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0058 0.0085
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0528 0.1015 0.1486
Plasmodium falciparum cysteine proteinase falcipain 3 0.0528 0.1015 0.4642
Brugia malayi Muscleblind-like protein 0.0146 0.0235 0.1092
Loa Loa (eye worm) cysteine protease 0.0528 0.1015 0.4721
Entamoeba histolytica hypothetical protein, conserved 0.1477 0.2953 1
Entamoeba histolytica cysteine protease, putative 0.0528 0.1015 0.3416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0009 0.0013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0528 0.1015 0.4721
Loa Loa (eye worm) hypothetical protein 0.0097 0.0136 0.0634
Plasmodium falciparum serine repeat antigen 9 0.0097 0.0136 0.0494
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.1084 0.2149 1
Entamoeba histolytica hypothetical protein, conserved 0.0708 0.1383 0.4666
Toxoplasma gondii cathepsin CPL 0.0528 0.1015 1
Leishmania major cathepsin L-like protease 0.0528 0.1015 0.4642
Brugia malayi cathepsin Z-like cysteine proteinase 0.0097 0.0136 0.0634
Wolbachia endosymbiont of Brugia malayi biotin-(acetyl-CoA carboxylase) ligase 0.1084 0.2149 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0032 0.0107
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0088 0.0411
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0136 0.0201
Toxoplasma gondii thioredoxin reductase 0.0046 0.0032 0.0228
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0097 0.0136 0.0634
Loa Loa (eye worm) hypothetical protein 0.0314 0.0579 0.2694
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0174 0.0294 0.1366
Brugia malayi cathepsin L-like precursor 0.0353 0.0658 0.3064
Loa Loa (eye worm) hypothetical protein 0.0353 0.0658 0.3064
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0009 0.0013
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0032 0.0147
Onchocerca volvulus 0.0528 0.1015 1
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0088 0.0129
Loa Loa (eye worm) glutathione reductase 0.0046 0.0032 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Entamoeba histolytica cysteine proteinase, putative 0.0272 0.0492 0.1642
Entamoeba histolytica hypothetical protein, conserved 0.1477 0.2953 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Brugia malayi Pre-SET motif family protein 0.0243 0.0433 0.2015
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0058 0.0086
Echinococcus granulosus muscleblind protein 0.0146 0.0235 0.0344
Echinococcus granulosus cathepsin L cysteine protease 0.0272 0.0492 0.0722
Echinococcus granulosus cathepsin l1 0.0353 0.0658 0.0965
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0097 0.0136 0.0634
Trypanosoma brucei Biotin--acetyl-CoA-carboxylase ligase, putative 0.1084 0.2149 1
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Plasmodium falciparum serine repeat antigen 5 0.0097 0.0136 0.0494
Echinococcus multilocularis transient receptor potential cation channel 0.3376 0.6828 1
Brugia malayi Cathepsin L-like precursor 0.0528 0.1015 0.4721
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0097 0.0136 0.0494
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.3346 0.6766 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.1015 1
Loa Loa (eye worm) biotin protein ligase 1 0.1084 0.2149 1
Loa Loa (eye worm) cathepsin B 0.0097 0.0136 0.0634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Mycobacterium leprae POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS 0.0769 0.1508 1
Leishmania major cathepsin L-like protease 0.0528 0.1015 0.4642
Trypanosoma cruzi cysteine proteinase, putative 0.0272 0.0492 0.2176
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0136 0.0201
Entamoeba histolytica hypothetical protein, conserved 0.1477 0.2953 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Brugia malayi cathepsin B-like cysteine proteinase 0.0097 0.0136 0.0634
Entamoeba histolytica cysteine protease, putative 0.0097 0.0136 0.0432
Loa Loa (eye worm) hypothetical protein 0.0097 0.0136 0.0634
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0528 0.1015 0.4642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0272 0.0492 0.0728
Trypanosoma cruzi cysteine proteinase, putative 0.0272 0.0492 0.2176
Onchocerca volvulus Cathepsin L homolog 0.0528 0.1015 1
Onchocerca volvulus Putative lipoyltransferase 2, mitochondrial 0.0314 0.0579 0.567
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Brugia malayi cathepsin L precursor 0.0097 0.0136 0.0634
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0097 0.0136 0.0597
Leishmania major cathepsin L-like protease 0.0528 0.1015 0.4642
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0097 0.0136 0.0432
Plasmodium falciparum serine repeat antigen 6 0.0097 0.0136 0.0494
Onchocerca volvulus 0.0528 0.1015 1
Echinococcus granulosus octanoyltransferase mitochondrial 0.0314 0.0579 0.0849
Trypanosoma cruzi lipoyltransferase, putative 0.0314 0.0579 0.2585
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0058 0.0085
Loa Loa (eye worm) hypothetical protein 0.0769 0.1508 0.7015
Trypanosoma cruzi major cysteine proteinase, putative 0.0097 0.0136 0.0494
Leishmania major lipoate-protein ligase-like,lipoyl ligase, putative,lipoyltransferase, putative,lipoate biosynthesis protein, putative 0.0314 0.0579 0.2585
Schistosoma mansoni cathepsin B (C01 family) 0.0097 0.0136 0.0201
Entamoeba histolytica cysteine proteinase, putative 0.0272 0.0492 0.1642
Toxoplasma gondii preprocathepsin c precursor, putative 0.0097 0.0136 0.1269
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Chlamydia trachomatis biotin synthetase 0.1084 0.2149 0.6615
Brugia malayi biotin--acetyl-CoA-carboxylase ligase family protein 0.1084 0.2149 1
Plasmodium falciparum serine repeat antigen 8 0.0097 0.0136 0.0494
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0097 0.0136 0.0634
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0097 0.0136 0.0597
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0058 0.0086
Mycobacterium tuberculosis Probable reductase 0.0105 0.0152 0.0121
Plasmodium falciparum cysteine proteinase falcipain 1 0.0272 0.0492 0.2176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Mycobacterium ulcerans lipoate-protein ligase B 0.0314 0.0579 0.056
Loa Loa (eye worm) fibroinase 0.0528 0.1015 0.4721
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0009 0.0013
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0097 0.0136 0.0201
Brugia malayi TAR-binding protein 0.0074 0.0088 0.0411
Echinococcus granulosus cathepsin b 0.0097 0.0136 0.02
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0174 0.0294 0.1366
Loa Loa (eye worm) ctsf protein 0.0528 0.1015 0.4721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Chlamydia trachomatis hypothetical protein 0.1477 0.2953 1
Entamoeba histolytica cysteine proteinase, putative 0.0272 0.0492 0.1642
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0088 0.013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0009 0.0013
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0097 0.0136 0.0634
Brugia malayi lipoate-protein ligase, mitochondrial precursor, putative 0.0314 0.0579 0.2694
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0009 0.0013
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0272 0.0492 0.0728
Trypanosoma cruzi cysteine peptidase, putative 0.0272 0.0492 0.2176
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0097 0.0136 0.0597
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0097 0.0136 0.0494
Entamoeba histolytica cysteine proteinase, putative 0.0528 0.1015 0.3416
Plasmodium vivax biotin--[acetyl-CoA-carboxylase] synthetase, putative 0.1084 0.2149 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0528 0.1015 0.1487
Loa Loa (eye worm) hypothetical protein 0.0146 0.0235 0.1092
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0097 0.0136 0.0201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.1015 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0058 0.0126
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0235 0.0344
Plasmodium vivax serine-repeat antigen (SERA) 0.0097 0.0136 0.0597
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0097 0.0136 0.0597
Leishmania major cathepsin L-like protease 0.0528 0.1015 0.4642
Echinococcus granulosus transient receptor potential cation channel 0.0031 0.000000074588 0.00000010933
Brugia malayi Papain family cysteine protease containing protein 0.0528 0.1015 0.4721
Brugia malayi Cathepsin L-like cysteine proteinase 0.0353 0.0658 0.3064
Brugia malayi cathepsin F-like cysteine proteinase 0.0097 0.0136 0.0634
Echinococcus multilocularis biotin protein ligase 0.1084 0.2149 0.3147
Brugia malayi Cathepsin L-like precursor 0.0528 0.1015 0.4721
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.1015 1
Loa Loa (eye worm) hypothetical protein 0.0353 0.0658 0.3064
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Echinococcus multilocularis ankyrin repeat protein 0.3346 0.6766 0.9908
Echinococcus multilocularis muscleblind protein 0.0146 0.0235 0.0344
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0136 0.0201
Trypanosoma cruzi cysteine peptidase, putative 0.0528 0.1015 0.4642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.1015 1
Entamoeba histolytica hypothetical protein, conserved 0.1477 0.2953 1
Echinococcus multilocularis octanoyltransferase, mitochondrial 0.0314 0.0579 0.0848
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0136 0.0201
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0097 0.0136 0.0201
Entamoeba histolytica cysteine protease, putative 0.0097 0.0136 0.0432
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0088 0.013
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0152 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Trypanosoma cruzi cruzipain precursor, putative 0.0174 0.0294 0.1237
Echinococcus multilocularis cathepsin L 0.0272 0.0492 0.0721
Entamoeba histolytica hypothetical protein, conserved 0.1477 0.2953 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0152 0.0121
Brugia malayi lipoate-protein ligase B containing protein 0.0314 0.0579 0.2694
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Toxoplasma gondii cathepsin CPC1 0.0097 0.0136 0.1269
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.004
Plasmodium falciparum serine repeat antigen 4 0.0097 0.0136 0.0494
Brugia malayi Cathepsin L-like precursor 0.0353 0.0658 0.3064
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0176 0.0145
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.1015 1
Schistosoma mansoni cathepsin S (C01 family) 0.0097 0.0136 0.0201
Plasmodium vivax unspecified product 0.0272 0.0492 0.226
Echinococcus granulosus N terminal of biotin protein ligase 0.1477 0.2953 0.4328
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Loa Loa (eye worm) hypothetical protein 0.0146 0.0235 0.1092
Onchocerca volvulus Cathepsin L homolog 0.0528 0.1015 1
Onchocerca volvulus 0.0528 0.1015 1
Onchocerca volvulus 0.0097 0.0136 0.1269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Brugia malayi hypothetical protein 0.0035 0.0009 0.0042
Plasmodium vivax lipoate-protein ligase 1, putative 0.0314 0.0579 0.2665
Plasmodium falciparum biotin protein ligase, putative 0.1084 0.2149 1
Loa Loa (eye worm) hypothetical protein 0.0353 0.0658 0.3064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.0433 0.2015
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0088 0.013
Brugia malayi cathepsin L-like cysteine proteinase 0.0097 0.0136 0.0634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0097 0.0136 0.0597
Brugia malayi Thioredoxin reductase 0.0046 0.0032 0.0147
Entamoeba histolytica cysteine protease, putative 0.0097 0.0136 0.0432
Echinococcus granulosus ankyrin repeat protein 0.3346 0.6766 0.9917
Toxoplasma gondii cathepsin CPC2 0.0097 0.0136 0.1269
Trypanosoma cruzi cysteine peptidase, putative 0.0528 0.1015 0.4642
Echinococcus granulosus cathepsin l1 0.0528 0.1015 0.1487
Entamoeba histolytica cysteine proteinase, putative 0.0272 0.0492 0.1642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Plasmodium falciparum serine repeat antigen 3 0.0097 0.0136 0.0494
Toxoplasma gondii lipoyl(octanoyl) transferase 0.0314 0.0579 0.567
Entamoeba histolytica hypothetical protein, conserved 0.1477 0.2953 1
Plasmodium vivax vivapain-2 0.0528 0.1015 0.47
Entamoeba histolytica cysteine proteinase 1, putative 0.0272 0.0492 0.1642
Entamoeba histolytica cysteine proteinase, putative 0.0528 0.1015 0.3416
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.1084 0.2149 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0097 0.0136 0.0432
Plasmodium vivax unspecified product 0.0174 0.0294 0.1331
Plasmodium vivax vivapain-2 0.0528 0.1015 0.47
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0176 0.0145
Toxoplasma gondii cathepsin B 0.0097 0.0136 0.1269
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0009 0.0013
Leishmania major cysteine peptidase A (CPA) 0.0528 0.1015 0.4642
Echinococcus granulosus cathepsin L 0.0272 0.0492 0.0722
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0097 0.0136 0.0201
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0152 0.0121
Leishmania major cathepsin L-like protease 0.0528 0.1015 0.4642
Brugia malayi Cathepsin L-like precursor 0.0528 0.1015 0.4721
Echinococcus granulosus cathepsin b 0.0097 0.0136 0.02
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0009 0.0013
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0097 0.0136 0.0597
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Onchocerca volvulus Cathepsin F homolog 0.0528 0.1015 1
Leishmania major cathepsin L-like protease 0.0528 0.1015 0.4642
Plasmodium vivax serine-repeat antigen (SERA) 0.0097 0.0136 0.0597
Trichomonas vaginalis lipoate-protein ligase, putative 0.0314 0.0579 0.504
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0097 0.0136 0.0494
Mycobacterium tuberculosis Probable lipoate biosynthesis protein B LipB 0.0314 0.0579 0.0549
Schistosoma mansoni biotin-protein ligase 0.1477 0.2953 0.4364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0006 0.0009
Echinococcus granulosus cysteine protease 0.0272 0.0492 0.0722
Giardia lamblia Hypothetical protein 0.1084 0.2149 1
Leishmania major biotin/lipoate protein ligase-like protein 0.1084 0.2149 1
Entamoeba histolytica cysteine protease, putative 0.0097 0.0136 0.0432
Entamoeba histolytica hypothetical protein, conserved 0.1477 0.2953 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0097 0.0136 0.0494
Onchocerca volvulus 0.0528 0.1015 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.1015 1
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0088 0.0411
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0176 0.0145
Loa Loa (eye worm) hypothetical protein 0.0097 0.0136 0.0634
Leishmania major cathepsin L-like protease 0.0528 0.1015 0.4642
Onchocerca volvulus 0.0279 0.0508 0.4962
Brugia malayi Cathepsin L-like precursor 0.0528 0.1015 0.4721
Brugia malayi Papain family cysteine protease containing protein 0.0272 0.0492 0.2291
Trypanosoma cruzi cysteine peptidase, putative 0.0528 0.1015 0.4642
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0152 0.0121
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0272 0.0492 0.2176
Plasmodium vivax vivapain-1 0.0272 0.0492 0.226
Brugia malayi Cathepsin L-like precursor 0.0174 0.0294 0.1366
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0528 0.1015 0.4642
Treponema pallidum biotin--acetyl-CoA-carboxylase ligase 0.493 1 0.5
Onchocerca volvulus 0.0528 0.1015 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0097 0.0136 0.0597
Echinococcus granulosus tar DNA binding protein 0.0074 0.0088 0.0129
Mycobacterium ulcerans bifunctional protein BirA 0.4616 0.9359 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0088 0.013
Onchocerca volvulus 0.0353 0.0658 0.6461
Plasmodium falciparum serine repeat antigen 2 0.0097 0.0136 0.0494
Brugia malayi Cathepsin L-like precursor 0.0353 0.0658 0.3064
Brugia malayi Cathepsin L-like precursor 0.0528 0.1015 0.4721
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0136 0.0201
Echinococcus multilocularis cathepsin b 0.0097 0.0136 0.02
Brugia malayi fibroinase precursor 0.0097 0.0136 0.0634
Entamoeba histolytica cysteine proteinase, putative 0.0353 0.0658 0.2206
Mycobacterium leprae Probable lipoate biosynthesis protein B LipB 0.0314 0.0579 0.3149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0658 0.5946
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0353 0.0658 0.2961
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0272 0.0492 0.4054
Echinococcus multilocularis N terminal of biotin protein ligase 0.1477 0.2953 0.4324
Onchocerca volvulus 0.0528 0.1015 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0528 0.1015 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0174 0.0294 0.1366
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0136 0.0201
Schistosoma mansoni biotin-protein ligase 0.1084 0.2149 0.3176
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0088 0.013
Entamoeba histolytica cysteine protease, putative 0.0097 0.0136 0.0432
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0058 0.0494
Loa Loa (eye worm) hypothetical protein 0.0174 0.0294 0.1366
Loa Loa (eye worm) hypothetical protein 0.0097 0.0136 0.0634
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0136 0.0201
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Entamoeba histolytica biotin--acetyl-CoA-carboxylase ligase, putative 0.1084 0.2149 0.727
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0058 0.0027
Echinococcus multilocularis cathepsin L cysteine protease 0.0528 0.1015 0.1486
Loa Loa (eye worm) hypothetical protein 0.0097 0.0136 0.0634
Echinococcus granulosus cathepsin L 0.0097 0.0136 0.02
Trypanosoma cruzi cysteine peptidase, putative 0.0528 0.1015 0.4642
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0152 0.0121
Plasmodium vivax glutathione reductase, putative 0.0046 0.0032 0.0107
Schistosoma mansoni cathepsin F (C01 family) 0.0528 0.1015 0.15
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0176 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Entamoeba histolytica hypothetical protein 0.0097 0.0136 0.0432
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0032 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0174 0.0294 0.1237
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0528 0.1015 1
Plasmodium falciparum serine repeat antigen 1 0.0097 0.0136 0.0494
Entamoeba histolytica cysteine protease, putative 0.0272 0.0492 0.1642
Loa Loa (eye worm) hypothetical protein 0.0528 0.1015 0.4721
Onchocerca volvulus 0.0528 0.1015 1
Schistosoma mansoni cathepsin F (C01 family) 0.0528 0.1015 0.15
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.1015 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Loa Loa (eye worm) hypothetical protein 0.0769 0.1508 0.7015
Brugia malayi Cathepsin L-like precursor 0.0528 0.1015 0.4721
Echinococcus granulosus 5'partial|biotin protein ligase 0.0769 0.1508 0.221
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0097 0.0136 0.0494
Trypanosoma cruzi cysteine protease, putative 0.0272 0.0492 0.2176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Plasmodium vivax vivapain-3 0.0272 0.0492 0.226
Loa Loa (eye worm) hypothetical protein 0.0174 0.0294 0.1366
Schistosoma mansoni cathepsin s 0.0174 0.0294 0.0434
Trypanosoma cruzi major cysteine proteinase, putative 0.0097 0.0136 0.0494
Brugia malayi glutathione reductase 0.0046 0.0032 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.1015 1
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0088 0.0411
Plasmodium falciparum lipoate-protein ligase 1 0.0314 0.0579 0.2585
Trypanosoma cruzi lipoate-protein ligase, putative 0.0314 0.0579 0.2585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.1015 1
Plasmodium falciparum biotin--acetyl-CoA-carboxylase, putative 0.1084 0.2149 1
Entamoeba histolytica hypothetical protein, conserved 0.1477 0.2953 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0528 0.1015 0.1486
Echinococcus multilocularis cysteine protease 0.0528 0.1015 0.1486
Brugia malayi Papain family cysteine protease containing protein 0.0272 0.0492 0.2291
Loa Loa (eye worm) hypothetical protein 0.0097 0.0136 0.0634
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0009 0.0013
Echinococcus multilocularis cysteine protease 0.0528 0.1015 0.1486
Mycobacterium tuberculosis Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas 0.0769 0.1508 0.1481
Loa Loa (eye worm) hypothetical protein 0.0174 0.0294 0.1366
Entamoeba histolytica cysteine proteinase 2 0.0272 0.0492 0.1642
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0136 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0528 0.1015 0.4642

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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