Detailed view for EgrG_001110900

Basic information

TDR Targets ID: 585961
Echinococcus granulosus, synaptotagmin
Source Database / ID:  GeneDB

pI: 8.7778 | Length (AA): 420 | MW (Da): 47082 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0008021   synaptic vesicle  
GO:0005544   calcium-dependent phospholipid binding  
GO:0007269   neurotransmitter secretion  

Metabolic Pathways

Synaptic vesicle cycle (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
144 418 2r83 (A) 140 412 68.00 0 1 1.46946 -0.58
155 269 5h4y (A) 109 232 57.00 0 1 0.94881 -0.99
155 258 1ugk (A) 8 122 52.00 0 1 0.773419 -0.16
162 415 1dqv (A) 314 567 54.00 0 1 1.15156 0.53
280 414 3n5a (A) 268 402 48.00 0 1 1.00123 -1.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130913)

Species Accession Gene Product
Brugia malayi Bm1_50215   Synaptotagmin protein 3
Caenorhabditis elegans CELE_Y75B7AL.3   Protein SNT-3
Caenorhabditis elegans CELE_F31E8.2   Protein SNT-1, isoform B
Drosophila melanogaster Dmel_CG3139   Synaptotagmin 1
Echinococcus granulosus EgrG_001110900   synaptotagmin
Echinococcus multilocularis EmuJ_001110900   synaptotagmin
Homo sapiens ENSG00000143858   synaptotagmin II
Homo sapiens ENSG00000067715   synaptotagmin I
Loa Loa (eye worm) LOAG_01082   hypothetical protein
Loa Loa (eye worm) LOAG_09289   synaptotagmin-1
Mus musculus ENSMUSG00000026452   synaptotagmin II
Mus musculus ENSMUSG00000035864   synaptotagmin I
Schistosoma japonicum Sjp_0119320   Synaptotagmin-1, putative
Schistosoma mansoni Smp_150920   synaptotagmin
Schistosoma mansoni Smp_194330   synaptotagmin 12
Schmidtea mediterranea mk4.012039.00   Synaptotagmin-8
Schmidtea mediterranea mk4.003756.01   Synaptotagmin, putative
Schmidtea mediterranea mk4.004753.00   Putative synaptotagmin 1,2
Schmidtea mediterranea mk4.008706.01  
Schmidtea mediterranea mk4.003017.01   Synaptotagmin, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0058 0.5 0.5
0.0057 0.3491 0.3491
0.0107 0.5 0.5
0.0071 0.2549 0.2498
0.0121 1 1
0.0018 0.5 0.5
0.0125 0.3893 0.9758
0.005 0.2612 0.2612
0.0072 0.2639 0.2639
0.0109 0.4866 0.4866

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001110900 (Echinococcus granulosus), synaptotagmin
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