pI: 8.8981 |
Length (AA): 205 |
MW (Da): 22649 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 38 | 2kzy (A) | 6 | 37 | 53.00 | 0 | 0.8 | 0.659854 | 0.42 |
15 | 51 | 2c7n (E) | 17 | 53 | 41.00 | 0.00034 | 0.83 | 0.710088 | -0.48 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127624)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G52800 | zinc finger A20 and AN1 domain-containing stress-associated protein 6 |
Arabidopsis thaliana | AT2G27580 | zinc finger A20 and AN1 domain-containing stress-associated protein 3 |
Arabidopsis thaliana | AT1G12440 | A20/AN1-like zinc finger family protein |
Arabidopsis thaliana | AT1G51200 | zinc finger A20 and AN1 domain-containing stress-associated protein 2 |
Arabidopsis thaliana | AT4G22820 | A20/AN1-like zinc finger family protein |
Arabidopsis thaliana | AT4G12040 | zinc finger A20 and AN1 domain-containing stress-associated protein 7 |
Arabidopsis thaliana | AT2G36320 | zinc finger A20 and AN1 domain-containing stress-associated protein 4 |
Babesia bovis | BBOV_III002670 | conserved hypothetical protein |
Brugia malayi | Bm1_56660 | AN1-like Zinc finger family protein |
Caenorhabditis elegans | CELE_F22D6.2 | Protein F22D6.2 |
Cryptosporidium hominis | Chro.10110 | zinc finger transcription factor ZFP33 |
Cryptosporidium parvum | cgd1_910 | ZnF A20 and Znf AN1 domains, involved in signaling |
Dictyostelium discoideum | DDB_G0276881 | hypothetical protein |
Drosophila melanogaster | Dmel_CG45050 | CG45050 gene product from transcript CG45050-RF |
Drosophila melanogaster | Dmel_CG43675 | CG43675 gene product from transcript CG43675-RC |
Echinococcus granulosus | EgrG_001022700 | AN1 type zinc finger protein 5 |
Echinococcus granulosus | EgrG_000960100 | zinc finger A20 and AN1 domain containing protein |
Echinococcus granulosus | EgrG_000337500 | Zinc finger A20 type |
Echinococcus multilocularis | EmuJ_001022700 | AN1 type zinc finger protein 5 |
Echinococcus multilocularis | EmuJ_000337500 | Zinc finger, A20 type |
Echinococcus multilocularis | EmuJ_000960100 | zinc finger A20 and AN1 domain containing protein |
Homo sapiens | ENSG00000107372 | zinc finger, AN1-type domain 5 |
Homo sapiens | ENSG00000086666 | zinc finger, AN1-type domain 6 |
Loa Loa (eye worm) | LOAG_10887 | hypothetical protein |
Mus musculus | ENSMUSG00000030629 | zinc finger, AN1-type domain 6 |
Mus musculus | 22682 | zinc finger, AN1-type domain 5 |
Neospora caninum | NCLIV_005310 | LOC397781 protein, related |
Oryza sativa | 4325591 | Os01g0718000 |
Oryza sativa | 4334393 | Os03g0793000 |
Oryza sativa | 4329544 | Os02g0530300 |
Oryza sativa | 4342503 | Os07g0168800 |
Oryza sativa | 4334395 | Os03g0793300 |
Oryza sativa | 4341520 | Os06g0612800 |
Oryza sativa | 4334392 | Os03g0792900 |
Oryza sativa | 4328609 | Os02g0195600 |
Onchocerca volvulus | OVOC1737 | Zinc finger protein, putative homolog |
Plasmodium berghei | PBANKA_0712300 | zinc finger protein, putative |
Plasmodium falciparum | PF3D7_0818500 | zinc finger protein, putative |
Plasmodium knowlesi | PKNH_0501400 | zinc finger protein, putative |
Plasmodium vivax | PVX_089490 | hypothetical protein, conserved |
Plasmodium yoelii | PY00088 | hypothetical protein |
Schistosoma japonicum | Sjp_0124720 | Zinc finger A20 and AN1 domain-containing stress-associated protein 6, putative |
Schistosoma japonicum | Sjp_0039700 | AN1-type zinc finger protein 6, putative |
Schistosoma japonicum | Sjp_0208610 | Zinc finger A20 and AN1 domain-containing stress-associated protein 4, putative |
Schistosoma mansoni | Smp_105210 | zinc finger protein |
Schistosoma mansoni | Smp_072720 | zinc finger protein |
Schmidtea mediterranea | mk4.001843.00 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.001971.03 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.023205.00 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.004949.00 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.000033.33 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.024409.00 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.021225.00 | |
Schmidtea mediterranea | mk4.021695.01 | |
Schmidtea mediterranea | mk4.006757.00 | |
Schmidtea mediterranea | mk4.002144.05 | |
Schmidtea mediterranea | mk4.004949.01 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.012051.01 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.007565.00 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.001971.04 | Putative zinc finger protein |
Schmidtea mediterranea | mk4.003993.00 | |
Toxoplasma gondii | TGME49_221910 | AN1 family Zinc finger domain-containing protein |
Theileria parva | TP04_0113 | zinc finger protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0712300 | Plasmodium berghei | Slow | plasmo |
TGME49_221910 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.