Detailed view for EgrG_000436000

Basic information

TDR Targets ID: 589914
Echinococcus granulosus, otoferlin
Source Database / ID:  GeneDB

pI: 5.4964 | Length (AA): 2162 | MW (Da): 244585 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF08150   FerB (NUC096) domain
PF16165   Ferlin C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 121 3l9b (A) 1 122 26.00 0.0000014 1 0.522467 -1.18
209 341 6ewl (A) 3 130 22.00 0 0.57 0.197217 0.09
419 515 5yq3 (A) 26 127 28.00 0.1 0.04 0.0203659 2.47
873 977 3twy (A) 156 257 19.00 0.00041 0.15 0.0591661 0.39
1452 1590 4tql (A) 15 180 29.00 0.21 0.29 0.0477923 0.54
1638 1749 4wee (A) 138 249 26.00 0 0.93 0.314504 -0.19
1661 1749 2b3r (A) 1397 1490 19.00 0 0.17 0.0998656 0.33
1661 1748 4ns0 (A) 399 492 38.00 0.001 0.36 0.295203 0.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127502)

Species Accession Gene Product
Brugia malayi Bm1_51580   C2 domain containing protein
Caenorhabditis elegans CELE_F43G9.6   Protein FER-1, isoform A
Caenorhabditis elegans CELE_T05E8.1   Protein FERL-1
Drosophila melanogaster Dmel_CG5747   misfire
Echinococcus granulosus EgrG_000825200   myoferlin
Echinococcus granulosus EgrG_000436000   otoferlin
Echinococcus multilocularis EmuJ_000825200   myoferlin
Homo sapiens ENSG00000214814   fer-1-like family member 6
Homo sapiens ENSG00000115155   otoferlin
Homo sapiens ENSG00000135636   dysferlin
Homo sapiens ENSG00000249715   fer-1-like family member 5
Homo sapiens ENSG00000138119   myoferlin
Loa Loa (eye worm) LOAG_08121   hypothetical protein
Loa Loa (eye worm) LOAG_04010   C2 domain-containing protein
Mus musculus ENSMUSG00000062372   otoferlin
Mus musculus ENSMUSG00000013338   fer-1-like 4 (C. elegans)
Mus musculus ENSMUSG00000033788   dysferlin
Mus musculus ENSMUSG00000037432   fer-1-like 5 (C. elegans)
Mus musculus 631797   fer-1-like 6 (C. elegans)
Mus musculus ENSMUSG00000048612   myoferlin
Schistosoma japonicum Sjp_0114940   IPR000008,C2 calcium-dependent membrane targeting;IPR008973,C2 calcium/lipid-binding region, CaLB,domain-containing
Schistosoma japonicum Sjp_0133990   Otoferlin, putative
Schistosoma japonicum Sjp_0078120   Dysferlin, putative
Schistosoma japonicum Sjp_0215270   expressed protein
Schistosoma japonicum Sjp_0310470   Fer-1-like protein 6, putative
Schistosoma japonicum Sjp_0090660   Myoferlin, putative
Schistosoma japonicum Sjp_0114950   Otoferlin, putative
Schistosoma japonicum Sjp_0078130   Dysferlin, putative
Schistosoma japonicum Sjp_0119910   Dysferlin, putative
Schistosoma mansoni Smp_141010   fer-1-related
Schistosoma mansoni Smp_163750   otoferlin
Schmidtea mediterranea mk4.024643.00  
Schmidtea mediterranea mk4.025195.00  
Schmidtea mediterranea mk4.026228.00  
Schmidtea mediterranea mk4.000386.02  
Schmidtea mediterranea mk4.023396.00   Sperm vesicle fusion protein fer-1
Schmidtea mediterranea mk4.027077.00  
Schmidtea mediterranea mk4.001392.11   Putative otoferlin
Schmidtea mediterranea mk4.000573.07  
Schmidtea mediterranea mk4.057194.00  
Schmidtea mediterranea mk4.000386.05  
Schmidtea mediterranea mk4.023120.00  
Schmidtea mediterranea mk4.000386.03  
Schmidtea mediterranea mk4.001392.10   Putative otoferlin
Schmidtea mediterranea mk4.000573.06  
Schmidtea mediterranea mk4.001392.07  
Schmidtea mediterranea mk4.000386.04  
Schmidtea mediterranea mk4.022631.00  
Schmidtea mediterranea mk4.025195.01  
Schmidtea mediterranea mk4.001392.09  
Schmidtea mediterranea mk4.001392.06  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0018 0.5 0.5
0.0125 0.3893 0.9758
0.0107 0.5 0.5
0.0057 0.3491 0.3491
0.0058 0.5 0.5
0.0071 0.2549 0.2498
0.0121 1 1
0.0109 0.4866 0.4866
0.0072 0.2639 0.2639
0.005 0.2612 0.2612

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000436000 (Echinococcus granulosus), otoferlin
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