Detailed view for EgrG_000857200

Basic information

TDR Targets ID: 592183
Echinococcus granulosus, synaptotagmin
Source Database / ID:  GeneDB

pI: 9.2116 | Length (AA): 841 | MW (Da): 94106 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF02318   FYVE-type zinc finger

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0008021   synaptic vesicle  
GO:0017137   Rab GTPase binding  
GO:0006887   exocytosis  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 108 1tjl (A) 33 141 28.00 0.14 0.17 0.368995 -0.42
31 145 2zet (C) 4 124 25.00 0.0029 0.57 0.369442 0.04
83 126 2yqm (A) 27 68 38.00 0.4 0.89 0.377219 0.84
486 609 4mjj (A) 90 216 38.00 0 1 0.618644 -1.28
486 766 2r83 (A) 142 417 33.00 0 1 0.726326 -0.19
624 769 4ldc (A) 267 408 49.00 0 1 0.815503 -0.92
625 732 2b3r (A) 1384 1489 30.00 0.000014 0.98 0.477319 -0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132530)

Species Accession Gene Product
Brugia malayi Bm1_26340   C2 domain containing protein
Caenorhabditis elegans CELE_F37A4.7   Protein RBF-1, isoform A
Drosophila melanogaster Dmel_CG11556   Rabphilin
Echinococcus granulosus EgrG_000857200   synaptotagmin
Echinococcus granulosus EgrG_001189100   actin protein 8
Echinococcus multilocularis EmuJ_001189100   actin protein 8
Echinococcus multilocularis EmuJ_000857200   synaptotagmin
Homo sapiens 8447   double C2-like domains, beta
Homo sapiens ENSG00000089169   rabphilin 3A
Loa Loa (eye worm) LOAG_11485   hypothetical protein
Loa Loa (eye worm) LOAG_00001   hypothetical protein
Mus musculus ENSMUSG00000020848   double C2, beta
Mus musculus ENSMUSG00000029608   rabphilin 3A
Schistosoma japonicum Sjp_0003400   Actin-related protein 8, putative
Schistosoma japonicum Sjp_0003390   Double C2-like domain-containing protein alpha, putative
Schistosoma japonicum Sjp_0003410   IPR004000,Actin/actin-like,domain-containing
Schistosoma japonicum Sjp_0003370   Rabphilin-3A, putative
Schistosoma japonicum Sjp_0088460   IPR003315,Rabphilin-3A effector;IPR010911,Rab-binding;IPR011011,Zinc finger, FYVE/PHD-type,domain-containing
Schistosoma mansoni Smp_145120   rabphilin-3a
Schmidtea mediterranea mk4.010872.00   Actin-related protein 8
Schmidtea mediterranea mk4.004160.00   Rabphilin-1
Schmidtea mediterranea mk4.026804.00   Rabphilin-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0109 0.4866 0.4866
0.0107 0.5 0.5
0.0125 0.3893 0.9758
0.0018 0.5 0.5
0.0071 0.2549 0.2498
0.0121 1 1
0.0072 0.2639 0.2639
0.0057 0.3491 0.3491
0.0058 0.5 0.5
0.005 0.2612 0.2612

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000857200 (Echinococcus granulosus), synaptotagmin
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