pI: 7.4073 |
Length (AA): 1774 |
MW (Da): 200212 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 18 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 258 | 1uoc (A) | 12 | 286 | 37.00 | 0 | 1 | 0.56 | -2.02 |
6 | 268 | 4gmj (B) | 11 | 280 | 56.00 | 0 | 1 | 0.852453 | -1.5 |
7 | 257 | 2p51 (A) | 22 | 271 | 49.00 | 0 | 1 | 0.850388 | -1.65 |
9 | 331 | 3d45 (A) | 2 | 493 | 19.00 | 0.000000000044 | 1 | 0.245274 | 0.01 |
521 | 756 | 4r6f (A) | 46 | 302 | 30.00 | 0.22 | 0.75 | 0.233933 | 0.48 |
525 | 1019 | 4mn8 (A) | 319 | 774 | 24.00 | 0.029 | 0.85 | 0.20093 | 0.97 |
911 | 1146 | 3n7l (A) | 920 | 1158 | 29.00 | 0.88 | 0.8 | 0.166933 | 0.7 |
1060 | 1230 | 4b60 (A) | 246 | 448 | 32.00 | 0.018 | 0.11 | 0.221292 | -0.3 |
1235 | 1341 | 3ult (A) | 6 | 114 | 27.00 | 0.00016 | 0.49 | 0.618216 | -2.65 |
1361 | 1771 | 1s0f (A) | 743 | 1185 | 25.00 | 0.97 | 0.86 | 0.11858 | 1.13 |
6 | 267 | 4gmj (B) | 11 | 279 | 56.00 | 0 | 1 | 0.852239 | -1.56 |
7 | 257 | 2p51 (A) | 22 | 271 | 49.00 | 0 | 1 | 0.843328 | -1.56 |
9 | 336 | 3d45 (B) | 2 | 502 | 18.00 | 0.0045 | 1 | 0.307106 | -0.2 |
1031 | 1641 | 3h09 (A) | 332 | 963 | 23.00 | 0.00000096 | 0.69 | 0.434603 | 0.65 |
1061 | 1231 | 4b60 (A) | 246 | 448 | 32.00 | 0.016 | 0.03 | 0.210156 | -0.25 |
1223 | 1338 | 3ult (A) | 6 | 114 | 28.00 | 0.00019 | 0.12 | 0.5341 | -2.51 |
1291 | 1744 | 3s5m (A) | 137 | 630 | 24.00 | 0.36 | 0.87 | 0.313952 | 0.75 |
1417 | 1686 | 4u0r (A) | 161 | 493 | 15.00 | 0.85 | 0 | 0.259356 | -0.35 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, Oocyst, Ring, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | early schizont, early trophozoite, late ring, late schizont, late trophozoite, Female Gametocyte, Male Gametocyte. | PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | gametocyte. | PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_127146)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G32070 | polynucleotidyl transferase, ribonuclease H-like superfamily protein |
Arabidopsis thaliana | AT1G80780 | putative CCR4-associated factor 1-like 6 |
Arabidopsis thaliana | AT5G10960 | polynucleotidyl transferase, ribonuclease H-like superfamily protein |
Babesia bovis | BBOV_III006830 | CAF1 family ribonuclease containing protein |
Brugia malayi | Bm1_07025 | CCR4-NOT transcription complex subunit 7 |
Candida albicans | CaO19.5734 | potential mRNA deadenylase similar to S. cerevisiae POP2/CAF1 (YNR052C) ribonuclease-like component of the cytoplasmic mRNA dead |
Candida albicans | CaO19.13156 | potential mRNA deadenylase similar to S. cerevisiae POP2/CAF1 (YNR052C) ribonuclease-like component of the cytoplasmic mRNA dead |
Caenorhabditis elegans | CELE_Y56A3A.20 | Protein CCF-1 |
Cryptosporidium hominis | Chro.30052 | hypothetical protein |
Cryptosporidium parvum | cgd3_350 | Pop2p-like 35 exonuclease, CCR4-NOT transcription complex |
Dictyostelium discoideum | DDB_G0284217 | CAF1 family protein |
Dictyostelium discoideum | DDB_G0285269 | CAF1 family protein |
Drosophila melanogaster | Dmel_CG5684 | CG5684 gene product from transcript CG5684-RA |
Echinococcus granulosus | EgrG_001187400 | CCR4 NOT transcription complex subunit 7 |
Entamoeba histolytica | EHI_039000 | CAF1 family ribonuclease, putative |
Entamoeba histolytica | EHI_048150 | CAF1 family ribonuclease, putative |
Echinococcus multilocularis | EmuJ_001187400 | CCR4 NOT transcription complex subunit 7 |
Giardia lamblia | GL50803_10606 | CCR4-NOT transcription complex, subunit 7 |
Giardia lamblia | GL50803_8209 | CCR4-NOT transcription complex, subunit 7 |
Homo sapiens | ENSG00000198791 | CCR4-NOT transcription complex, subunit 7 |
Homo sapiens | ENSG00000155508 | CCR4-NOT transcription complex, subunit 8 |
Leishmania braziliensis | LbrM.22.1540 | CCR4 associated factor, putative |
Leishmania donovani | LdBPK_221480.1 | ccr4-not transcription complex subunit |
Leishmania infantum | LinJ.22.1480 | CCR4 associated factor, putative |
Leishmania major | LmjF.22.1630 | CCR4 associated factor, putative |
Leishmania mexicana | LmxM.22.1630 | CCR4 associated factor, putative |
Loa Loa (eye worm) | LOAG_04270 | CCR4-NOT transcription complex subunit 7 |
Mus musculus | ENSMUSG00000020515 | CCR4-NOT transcription complex, subunit 8 |
Mus musculus | ENSMUSG00000031601 | CCR4-NOT transcription complex, subunit 7 |
Neospora caninum | NCLIV_026760 | CCR4-NOT transcription complex,subunit 7-like, related |
Oryza sativa | 4347066 | Os09g0416800 |
Oryza sativa | 4331006 | Os02g0796300 |
Plasmodium berghei | PBANKA_1426200 | CCR4-associated factor 1, putative |
Plasmodium falciparum | PF3D7_0811300 | CCR4-associated factor 1 |
Plasmodium knowlesi | PKNH_1429400 | CCR4-associated factor 1, putative |
Plasmodium vivax | PVX_123205 | CCR4-associated factor 1, putative |
Plasmodium yoelii | PY04679 | hypothetical protein |
Plasmodium yoelii | PY01168 | ccr4-not transcription complex, subunit 7 |
Saccharomyces cerevisiae | YNR052C | Pop2p |
Schistosoma japonicum | Sjp_0103700 | CCR4-NOT transcription complex subunit 7, putative |
Schistosoma mansoni | Smp_021870 | ccr4-associated factor |
Schmidtea mediterranea | mk4.003641.00 | CCR4-NOT transcription complex subunit 7 |
Schmidtea mediterranea | mk4.001247.20 | CCR4-NOT transcription complex subunit 7 |
Schmidtea mediterranea | mk4.002031.07 | CCR4-NOT transcription complex subunit 7 |
Schmidtea mediterranea | mk4.000784.10 | CCR4-NOT transcription complex subunit 7 |
Trypanosoma brucei gambiense | Tbg972.6.270 | CCR4 associated factor, putative |
Trypanosoma brucei | Tb927.6.600 | ccr4-not transcription complex subunit |
Trypanosoma congolense | TcIL3000_6_120 | ccr4-not transcription complex subunit |
Trypanosoma cruzi | TcCLB.510535.60 | CCR4-associated factor 1 |
Trypanosoma cruzi | TcCLB.511827.60 | ccr4-not transcription complex subunit |
Toxoplasma gondii | TGME49_260240 | ccr4-associated factor family protein |
Theileria parva | TP04_0580 | hypothetical protein |
Trichomonas vaginalis | TVAG_149020 | CCR4-associated factor, putative |
Trichomonas vaginalis | TVAG_007620 | CCR4-associated factor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.600 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.600 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y56A3A.20 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y56A3A.20 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y56A3A.20 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y56A3A.20 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y56A3A.20 | Caenorhabditis elegans | sterile | wormbase |
YNR052C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1426200 | Plasmodium berghei | Essential | plasmo |
TGME49_260240 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | CCR4-NOT transcription complex, subunit 7 | Compounds | References |