Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | sonic hedgehog | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K06224 hedgehog, putative | Get druggable targets OG5_131225 | All targets in OG5_131225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.4227 | 0.3664 |
Entamoeba histolytica | CAF1 family ribonuclease, putative | 0.0181 | 0.5761 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.0888 | 0.0327 |
Leishmania major | CCR4 associated factor, putative | 0.0181 | 0.5761 | 0.5347 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.0888 | 0.1153 |
Trypanosoma cruzi | CCR4-associated factor 1 | 0.0181 | 0.5761 | 0.55 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0018 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1321 | 0.1714 |
Giardia lamblia | CCR4-NOT transcription complex, subunit 7 | 0.0181 | 0.5761 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0918 | 0.0358 |
Onchocerca volvulus | 0.0026 | 0.0018 | 0.5 | |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.0888 | 0.0327 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.4813 | 0.5 |
Plasmodium vivax | CCR4-associated factor 1, putative | 0.0181 | 0.5761 | 0.5 |
Brugia malayi | Hint module family protein | 0.0061 | 0.1321 | 0.1695 |
Echinococcus multilocularis | CCR4 NOT transcription complex subunit 7 | 0.0181 | 0.5761 | 0.7737 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0018 | 0.0023 |
Onchocerca volvulus | 0.0026 | 0.0018 | 0.5 | |
Trichomonas vaginalis | CCR4-associated factor, putative | 0.0181 | 0.5761 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.4227 | 0.3871 |
Giardia lamblia | CCR4-NOT transcription complex, subunit 7 | 0.0181 | 0.5761 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0018 | 0.0023 |
Echinococcus granulosus | CCR4 NOT transcription complex subunit 7 | 0.0181 | 0.5761 | 0.7737 |
Trichomonas vaginalis | CCR4-associated factor, putative | 0.0181 | 0.5761 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1321 | 0.1714 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0888 | 0.1516 |
Loa Loa (eye worm) | CCR4-NOT transcription complex subunit 7 | 0.0181 | 0.5761 | 0.7476 |
Toxoplasma gondii | ccr4-associated factor family protein | 0.0181 | 0.5761 | 1 |
Echinococcus granulosus | Desert hedgehog protein | 0.0226 | 0.744 | 1 |
Schistosoma mansoni | ccr4-associated factor | 0.0181 | 0.5761 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 0.7706 | 1 |
Brugia malayi | Hint module family protein | 0.0061 | 0.1321 | 0.1695 |
Brugia malayi | follicle stimulating hormone receptor | 0.0233 | 0.7706 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.0888 | 0.0164 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.4227 | 0.3871 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.0888 | 0.1173 |
Trypanosoma brucei | ccr4-not transcription complex subunit | 0.0181 | 0.5761 | 0.55 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5159 | 0.8951 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.0888 | 0.1173 |
Echinococcus multilocularis | hedgehog | 0.0226 | 0.744 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.0888 | 0.0327 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.0888 | 0.1173 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.4813 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.0888 | 0.1173 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.0888 | 0.0327 |
Brugia malayi | CCR4-NOT transcription complex subunit 7 | 0.0181 | 0.5761 | 0.747 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.0888 | 0.0327 |
Trypanosoma cruzi | ccr4-not transcription complex subunit | 0.0181 | 0.5761 | 0.55 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.0888 | 0.0327 |
Plasmodium falciparum | CCR4-associated factor 1 | 0.0157 | 0.487 | 0.5 |
Entamoeba histolytica | CAF1 family ribonuclease, putative | 0.0181 | 0.5761 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.0888 | 0.1132 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7.6 nM | Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assay | ChEMBL. | 22985958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.