pI: 5.7507 |
Length (AA): 526 |
MW (Da): 56807 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 518 | 4b2t (B) | 9 | 524 | 53.00 | 0.0000000034 | 1 | 1.49339 | 0.06 |
3 | 517 | 4b2t (B) | 9 | 523 | 68.00 | 0 | 1 | 1.69149 | -0.16 |
210 | 358 | 1ass (A) | 2 | 150 | 27.00 | 0 | 1 | 0.69877 | -0.88 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127730)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G20890 | TCP-1/cpn60 chaperonin family protein |
Babesia bovis | BBOV_III000880 | T-complex protein beta subunit, putative |
Brugia malayi | Bm1_10270 | T-complex protein 1, beta subunit |
Brugia malayi | Bm1_28565 | T-complex protein 1, beta subunit |
Candida albicans | CaO19.1402 | similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Candida albicans | CaO19.8980 | similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Caenorhabditis elegans | CELE_T21B10.7 | Protein CCT-2 |
Cryptosporidium hominis | Chro.60586 | TCP-1/cpn60 chaperonin-related protein |
Cryptosporidium parvum | cgd6_5080 | GroEL-like chaperone (ATpase); T-complex protein 1 |
Dictyostelium discoideum | DDB_G0291358 | chaperonin containing TCP1 beta subunit |
Drosophila melanogaster | Dmel_CG7033 | CG7033 gene product from transcript CG7033-RA |
Echinococcus granulosus | EgrG_000702700 | chaperonin containing TCP1 subunit 2 beta |
Entamoeba histolytica | EHI_103270 | T-complex protein 1 beta subunit, putative |
Echinococcus multilocularis | EmuJ_000702700 | chaperonin containing TCP1, subunit 2 (beta) |
Giardia lamblia | GL50803_11397 | TCP-1 chaperonin subunit beta |
Homo sapiens | ENSG00000166226 | chaperonin containing TCP1, subunit 2 (beta) |
Leishmania braziliensis | LbrM.27.1370 | T-complex protein 1, beta subunit, putative |
Leishmania donovani | LdBPK_271150.1 | T-complex protein 1, beta subunit, putative |
Leishmania infantum | LinJ.27.1150 | T-complex protein 1, beta subunit, putative |
Leishmania major | LmjF.27.1260 | T-complex protein 1, beta subunit, putative |
Leishmania mexicana | LmxM.27.1260 | T-complex protein 1, beta subunit, putative |
Loa Loa (eye worm) | LOAG_01393 | T-complex protein 1 |
Mus musculus | ENSMUSG00000034024 | chaperonin containing Tcp1, subunit 2 (beta) |
Neospora caninum | NCLIV_018400 | TCP-1/cpn60 family chaperonin, putative |
Oryza sativa | 4339570 | Os05g0556700 |
Oryza sativa | 4333462 | Os03g0619400 |
Plasmodium berghei | PBANKA_0405200 | T-complex protein 1 subunit beta, putative |
Plasmodium falciparum | PF3D7_0306800 | T-complex protein 1 subunit beta |
Plasmodium knowlesi | PKNH_0835900 | T-complex protein 1 subunit beta, putative |
Plasmodium vivax | PVX_119465 | T-complex protein 1 subunit beta, putative |
Plasmodium yoelii | PY06837 | putative T-complex protein beta subunit |
Saccharomyces cerevisiae | YIL142W | Cct2p |
Schistosoma japonicum | Sjp_0301360 | ko:K09494 T-complex protein 1 subunit beta, putative |
Schistosoma mansoni | Smp_054340.3 | chaperonin containing t-complex protein 1 beta subunit tcpb |
Schistosoma mansoni | Smp_054340.2 | chaperonin containing t-complex protein 1 beta subunit tcpb |
Schistosoma mansoni | Smp_054340.1 | chaperonin containing t-complex protein 1 beta subunit tcpb |
Schmidtea mediterranea | mk4.001712.05 | T-complex protein 1 subunit beta |
Trypanosoma brucei gambiense | Tbg972.11.2030 | T-complex protein 1, beta subunit, putative |
Trypanosoma brucei | Tb927.11.1900 | T-complex protein 1, beta subunit, putative |
Trypanosoma cruzi | TcCLB.508357.90 | T-complex protein 1, beta subunit, putative |
Toxoplasma gondii | TGME49_243710 | t-complex protein beta subunit |
Theileria parva | TP03_0723 | T-complex protein 1, beta subunit, putative |
Trichomonas vaginalis | TVAG_177930 | chaperonin-60kD, ch60, putative |
Trichomonas vaginalis | TVAG_178890 | chaperonin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_T21B10.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T21B10.7 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T21B10.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T21B10.7 | Caenorhabditis elegans | sterile | wormbase |
YIL142W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0405200 | Plasmodium berghei | Essential | plasmo |
TGME49_243710 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Macaaca fascicularis | T-complex protein 1 subunit beta | Compounds | References |