Detailed view for EHI_158240

Basic information

TDR Targets ID: 797771
Entamoeba histolytica, fatty acid elongase, putative
Source Database / ID:  AmoebaDB  

pI: 8.537 | Length (AA): 495 | MW (Da): 56512 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08392   FAE1/Type III polyketide synthase-like protein
PF08541   3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0016747   transferase activity, transferring groups other than amino-acyl groups  
GO:0016020   membrane  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  
GO:0006633   fatty acid biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
88 493 2p0u (A) 32 405 17.00 0 1 0.907502 0.22
143 493 1z1e (A) 55 387 21.00 0 1 0.832391 0.16
184 289 5byv (A) 27 132 12.00 0.75 0.17 0.370441 -0.31
416 482 2d3m (A) 319 390 39.00 0.0073 0.46 0.481254 -0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_130146)

Species Accession Gene Product
Arabidopsis thaliana AT1G25450   3-ketoacyl-CoA synthase 5
Arabidopsis thaliana AT2G16280   3-ketoacyl-CoA synthase 9
Arabidopsis thaliana AT4G34250   3-ketoacyl-CoA synthase 16
Arabidopsis thaliana AT4G34510   3-ketoacyl-CoA synthase 17
Arabidopsis thaliana AT1G19440   3-ketoacyl-CoA synthase 4
Arabidopsis thaliana AT1G01120   3-ketoacyl-CoA synthase 1
Arabidopsis thaliana AT1G68530   3-ketoacyl-CoA synthase 6
Arabidopsis thaliana AT2G26250   3-ketoacyl-CoA synthase 10
Arabidopsis thaliana AT5G43760   3-ketoacyl-CoA synthase 20
Arabidopsis thaliana AT4G34520   3-ketoacyl-CoA synthase 18
Arabidopsis thaliana AT2G26640   3-ketoacyl-CoA synthase 11
Arabidopsis thaliana AT2G15090   3-ketoacyl-CoA synthase 8
Arabidopsis thaliana AT1G04220   3-ketoacyl-CoA synthase 2
Dictyostelium discoideum DDB_G0283621   fatty acid elongase 3-ketoacyl-CoA synthase
Entamoeba histolytica EHI_158240   fatty acid elongase, putative
Entamoeba histolytica EHI_111000   fatty acid elongase, putative
Entamoeba histolytica EHI_092190   fatty acid elongase, putative
Giardia lamblia GL50803_92729   Fatty acid elongase 1
Oryza sativa 4348145   Os10g0158100
Oryza sativa 4332090   Os03g0220100
Oryza sativa 4350817   Os11g0591200
Oryza sativa 4340691   Os06g0260500
Oryza sativa 4331836   Os03g0181500
Oryza sativa 4328676   Os02g0205500
Oryza sativa 4341445   Os06g0598800
Oryza sativa 4339645   Os05g0568000
Oryza sativa 4339684   Os05g0574600
Oryza sativa 4332236   Os03g0245700

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Arabidopsis thaliana 3-ketoacyl-CoA synthase 20 Compounds References
Arabidopsis thaliana 3-ketoacyl-CoA synthase 18 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 335 aa 20.7% 352 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.023 0.5096 1
0.0269 0.3293 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_158240 (Entamoeba histolytica), fatty acid elongase, putative
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