Detailed view for Rv0533c

Basic information

TDR Targets ID: 5974
Mycobacterium tuberculosis, 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)
Source Database / ID:  Tuberculist 

pI: 4.771 | Length (AA): 335 | MW (Da): 34873 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08541   3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08545   3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III

Gene Ontology

Mouse over links to read term descriptions.
GO:0004315   3-oxoacyl-[acyl-carrier-protein] synthase activity  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  
GO:0006633   fatty acid biosynthetic process  

Metabolic Pathways

Fatty acid biosynthesis (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 334 2qo0 (A) 0 317 99.99 0 1 2.15242 -0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1HZP:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1M1M:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1U6E:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1U6S:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2AHB:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2AJ9:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2QNX:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2QNY:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2QNZ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2QO0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2QO1:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2QX1:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_129509)

Species Accession Gene Product
Arabidopsis thaliana AT1G62640   3-ketoacyl-acyl carrier protein synthase III
Chlamydia trachomatis CT_239   oxoacyl-ACP synthase III
Escherichia coli b1091   3-oxoacyl-[acyl-carrier-protein] synthase III
Mycobacterium tuberculosis Rv0533c   3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)
Mycobacterium ulcerans MUL_3531   3-oxoacyl-ACP synthase
Mycobacterium ulcerans MUL_0632   3-oxoacyl-ACP synthase
Mycobacterium ulcerans MUP045   beta-ketoacyl synthase-like protein
Neospora caninum NCLIV_031900   3-oxoacyl-(acyl-carrier-protein) synthase III family protein, putative
Oryza sativa 4337178   Os04g0643300
Plasmodium berghei PBANKA_0308200   apicoplast beta-ketoacyl-acyl carrier protein synthase III precursor, putative
Plasmodium falciparum PF3D7_0211400   beta-ketoacyl-ACP synthase III
Plasmodium knowlesi PKNH_0409900   beta-ketoacyl-acyl carrier protein synthase III precursor, putative
Plasmodium vivax PVX_002960   beta-ketoacyl-acyl carrier protein synthase III precursor, putative
Schmidtea mediterranea mk4.058575.00  
Wolbachia endosymbiont of Brugia malayi Wbm0614   3-oxoacyl-ACP synthase

Essentiality

Rv0533c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu541 this record Mycobacterium tuberculosis non-essential nmpdr
b1091 Escherichia coli essential goodall
PBANKA_0308200 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 0   315193   584945  
Annotator: crowther@u.washington.edu. Comment: 2007-12-20. References: 10840036 14552758 17524982
response to drug (GO:0042493) normal (PATO:0000461) inferred from over expression (ECO:0000120) Mycobacterium tuberculosis 315193   584945  
Annotator: crowther@u.washington.edu. Comment: 2007-12-20. References: 10840036

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

Compound Source Reference
ChEMBL23 References
Curated by TDRTargets References
ChEMBL23 References
Curated by TDRTargets References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum beta-ketoacyl-ACP synthase III Compounds References
Pseudomonas aeruginosa 2-heptyl-4(1H)-quinolone synthase PqsD Compounds References
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) Beta-ketoacyl-ACP synthase III Compounds References
Escherichia coli 3-oxoacyl-[acyl-carrier-protein] synthase III Compounds References
Enterococcus faecalis (strain ATCC 700802 / V583) Beta-ketoacyl-ACP synthase III Compounds References
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Beta-ketoacyl-ACP synthase III Compounds References
Staphylococcus aureus subsp. aureus Mu50 Beta-ketoacyl-ACP synthase III Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0383 1 0.5
0.0973 1 1
0.4584 0.4255 0.5845
0.0348 0.6996 1
0.7725 0.835 1
0.164 1 0.5
0.5639 1 1
0.1914 0.6788 1
0.0652 0.7718 1
0.037 0.5382 1
0.3215 0.5754 1
0.5452 1 0.5
0.3118 0.5 0.5
0.0354 0.4517 1
0.0664 0.7037 1
0.0614 0.6127 1
0.0685 0.5471 0.5471
0.1259 0.3468 1
0.5675 1 0.5
0.0676 0.3879 1
0.0679 1 0.5
0.263 0.5923 0.8317
0.0671 0.7951 1
0.0383 0.4958 1
0.2248 0.8155 1
0.0719 0.9127 1
0.1256 1 1
0.0691 0.6027 1
0.5062 1 0.5
0.0383 0.4865 1
0.0708446 0.366129 0.344147
0.2304 0.4952 1
0.031 0.9523 0.9522
0.1006 0.4376 1
0.1282 0.3892 0.4181
0.1292 0.4144 0.446
0.1223 0.3002 1
0.1325 0.8144 1
0.5998 0.3308 1
0.2261 0.6961 1
0.0739 0.5517 0.5517
0.6515 0.5949 0.9007
0.4584 0.4255 0.5845
0.0696 0.7618 1
0.1309 0.3644 0.39
0.2837 1 0.5
0.0308 0.9274 1
0.0383 1 1
0.0332 0.3562 1
0.0368 1 0.5
0.3901 0.7328 1
0.3629 1 1
0.1294 0.3834 1
0.01 0.3216 0.5
0.0766 0.7124 1
0.0383 1 1
0.0693 0.7958 1
0.0999 1 1
0.054 1 1
0.3739 0.4903 1
0.6122 1 1
0.3811 0.4714 1
0.0328 0.7053 1
0.3215 1 0.5
0.3257 0.5567 1
0.2309 1 1
0.3811 0.4714 1
0.0383 0.4545 0.5
0.4842 0.2981 0.5033
0.1407 1 1
0.0368 0.278 1
0.0663 0.7509 1
0.5983 1 1
0.1978 0.3218 1
0.5452 0.4811 0.5
0.2874 0.6553 1
0.095 0.2934 0.3153
0.6515 0.5949 0.9007
0.2955 1 1
0.0308 0.7688 0.5
0.1612 0.3139 0.3368
0.0681 0.3899 0.9591
0.5786 1 0.5
0.0378 1 1
0.0383 0.4032 0.797
0.0688 1 1
0.0726 0.5691 0.5691
0.0383 0.9588 1
0.3609 0.7368 1
0.0708 0.3228 0.5501
0.263 0.5923 0.8317
0.3982 1 1
0.0343 0.4773 0.4755
0.032019 0.5 0.5
0.3609 0.7368 1
0.2309 1 1
0.0383 0.6484 1
0.3327 1 1
0.0732 0.3447 0.5
0.0383 1 1
0.0317 0.3763 1
0.0383 0.4335 0.5
0.0311 0.4201 1
0.0383 0.9692 1
0.3541 0.7682 0.5
0.0383 1 0.5
0.0368 0.278 1
0.066 0.4897 0.5
0.4842 0.2981 0.5033
0.4842 0.2981 0.5033
0.0654 0.3125 0.3125
0.2304 0.4952 1
0.5078 1 0.5
0.2108 1 1
0.0633 0.8912 1
0.1917 0.4141 1
0.3629 1 1
0.2304 0.4952 1
0.16 0.315 0.3355
0.3952 1 0.5
0.0339 1 0.5
0.3811 0.4714 1
0.0332 0.3562 1
0.0939 1 1
0.3739 0.4903 1
0.0323 0.5 0.5
0.0255 0.2567 1
0.4842 0.2981 0.5033
0.031 0.7616 0.9134
0.0618 0.5034 0.5428
0.1576 0.3201 0.3431
0.1634 0.2552 0.2743
0.2548 1 1
0.3811 0.4714 1
0.0989 0.6567 0.6937
0.0306 0.3628 0.5
0.0383 0.9588 1
0.0306 1 0.5
0.5337 1 0.5
0.1991 1 0.5
0.4842 0.2981 0.5033
0.0331 1 1
0.0366 0.2935 0.5208
0.4842 0.2981 0.5033
0.0725 1 0.5
0.29554 1 0.5
0.0784 0.7049 1
0.0368 0.278 1
0.0355 0.2725 1
0.5858 1 1
0.0635 0.3048 0.326
0.0357 0.4455 1
0.0306 0.45 1
0.0953 1 1
0.3304 1 0.5
0.1429 0.3393 1
0.8226 1 1
0.0628 0.6075 0.7513
0.0306 0.3778 1
0.4842 0.2981 0.5033
0.0632 1 0.5
0.1042 1 1
0.0654 0.5174 0.5174
0.8226 1 1
0.4584 0.4255 0.5845
0.2304 0.4952 1
0.0951 0.3024 0.3767
0.0314 0.3088 1
0.5078 1 0.5
0.0255 0.6557 1
0.0383 1 0.5
0.024 1 1
0.2487 1 0.5
0.0708 0.3228 0.5501
0.0657 0.7945 1
0.0627 1 0.5
0.0312 0.2517 1
0.034 0.4493 1
0.0691 0.6027 1
0.0696 0.7618 1
0.0719 0.9127 1
0.2548 1 1
0.3629 1 1
0.0383 0.3701 0.5
0.0496 1 0.5
0.3428 0.8401 0.5
0.0313 1 1
0.5786 1 0.5
0.0496 0.4617 1
0.0312 0.41 1
0.5644 0.8356 1
0.0728 0.5516 0.5516
0.4842 0.2981 0.5033
0.0383 1 1
0.0338 0.4629 1
0.1131 0.2805 1
0.0654 0.7347 1
0.3339 0.5 0.5
0.5636 0.5 0.5
0.0622 0.7377 1
0.0636 0.3197 1
0.0366 0.3586 0.5
0.162 0.297 0.3195
0.0629 0.9398 1
0.0627 0.6309 1
0.031 0.5876 1
0.0942 1 0.5
0.0676 1 1
0.0682 1 0.5
0.0383 0.9588 1
0.8226 1 1
0.4842 0.2981 0.5033
0.6219 1 0.5
0.037 0.4482 1
0.3609 0.7368 1
0.031 0.9036 0.5
0.0323 0.5105 0.9992
0.0689 0.3211 0.3211
0.0383 0.385 1
0.0966 0.2677 0.2879
0.0696 0.7618 1
0.5742 1 1
0.0383 0.359 1
0.3327 1 1
0.0705 0.552 0.552
0.0383 1 0.5
0.0383 0.9588 1
0.0383 0.2804 0.5
0.0659 0.2548 0.7845
0.0698 0.5315 0.5315
0.0953 1 1
0.3557 0.6869 1
0.4251 1 0.5
0.093 0.4226 0.4828
0.0698 0.3665 0.3663
0.0534 0.4564 1
0.0935 0.2715 1
0.0376 0.4455 1
0.187 1 1
0.0719 0.9127 1
0.0736 1 1
0.0665 0.7613 1
0.099 0.4733 1
0.0628 0.6075 0.7513
0.0673 0.7671 1
0.4666 1 1
0.2304 0.4952 1
0.0716 0.5522 0.5522
0.718 0.3489 0.7664
0.8226 1 1
0.0368 0.278 1
0.0383 0.5614 0.5
0.0383 0.8674 1
0.3315 1 1
0.4842 0.2981 0.5033
0.1919 1 1
0.9741 1 1
0.0999 0.6659 0.7016
0.0646 0.4686 0.4686
0.1626 0.2676 0.2878
0.0311 0.4455 1
0.4842 0.2981 0.5033
0.6119 0.3491 0.3489
0.2548 1 1
0.2324 1 1
0.0338 0.4629 1
0.6119 0.3491 0.3489
0.4842 0.2981 0.5033
0.0383 0.4344 0.8139
0.0312 1 1
0.6021 0.5 0.5
0.0306 0.3164 1
0.0973 1 1
0.1079 1 0.5
0.1294 0.3834 1
0.4584 0.4255 0.5845
0.0534 0.6511 1
0.146 1 0.5
0.3557 0.6869 1
0.3557 0.6869 1
0.1638 0.2678 0.2877
0.6977 1 1
0.0354 0.4517 1
0.0655 0.6958 1
0.033 0.7053 1
0.0653 1 0.5
0.0348 0.3486 0
0.1428 1 1
0.8226 1 1
0.3327 1 1
0.0383 1 1
0.0368 0.7433 0.6532
0.1665 1 1
0.0331 1 1
0.0316 1 1
0.0969 0.2685 0.2877
0.0619 0.7054 1
0.0624 0.2956 1
0.0335 0.6536 0.3774
0.0979 1 1
0.1034 1 1
0.0656 0.9252 1
0.0255 0.2567 1
0.0667 1 1
0.1364 1 0.5
0.1413 0.4622 0.4952
0.1312 0.5244 1
0.031 0.9523 0.9522
0.0383 1 1
0.1853 0.4505 0.4503
0.1149 1 1
0.1017 1 1
0.1294 0.3834 1
0.0383 1 0.5
0.032 0.9532 1
0.4842 0.2981 0.5033
0.0383 1 0.5
0.7647 0.3597 1
0.1347 1 0.5
0.0626 0.3026 0.3023
0.037 0.643 1
0.0973 1 0.5
0.0383 1 1
0.1343 1 0.5
0.263 0.5923 0.8317
0.0383 0.5 0.5
0.3025 1 1
0.0383 0.9488 0.5
0.0315 0.3938 0.4992
0.7924 1 1
0.101 1 0.5
0.0309 0.3023 1
0.1259 0.3468 1
0.5231 1 1
0.2955 1 1
0.0637 1 1
0.3327 1 1
0.1612 0.2801 0.3009
0.0383 0.7791 1
0.0314 0.4438 1
0.3811 0.4714 1
0.0503 0.3914 1
0.0383 0.3232 0.2904
0.4261 1 0.5
0.4584 0.4255 0.5845
0.0679 0.927 1
0.3257 0.5567 1
0.8226 1 1
0.3811 0.4714 1
0.0614 0.6006 1
0.031 1 0.5
0.8226 1 1
0.6515 0.5949 0.9007
0.027 1 1
0.066 0.4897 0.5
0.0365 0.7308 1
0.0677 1 1
0.345 1 1
0.032 0.6163 1
0.0655 0.7612 1
0.4842 0.2981 0.5033
0.1278 1 0.5
0.16 0.3825 0.4074
0.0383 0.4713 1
0.4218 1 0.5
0.0307 1 0.5
0.0978 1 0.5
0.0935 0.2715 1
0.0633 1 1
0.0383 0.5281 0.5232
0.6515 0.5949 0.9007
0.6062 1 1
0.8226 1 1
0.5983 1 1
0.6214 1 1
0.0307 0.3822 0.4283
0.0942 0.371 0.8585
0.0645 0.3634 0.3905
0.6062 1 1
0.29 0.5 0.5
0.032 0.6163 1
0.1003 0.4744 0.4788
0.0645 0.256 1
0.3982 1 1
0.073 0.5 0.5
0.1036 1 0.5
0.2304 0.4952 1
0.0368 0.278 1
0.0619 0.7308 1
0.0383 0.4705 1
0.1308 0.2682 0.2864
0.1259 0.3468 1
0.1263 0.3232 1
0.0739 0.5517 0.5517
0.0383 0.2564 0.5
0.1131 0.2805 1
0.0981 0.2552 0.2732
0.0633 1 1
0.0659 0.7833 1
0.7725 0.835 1
0.0383 1 1
0.0383 1 1
0.1667 0.2604 0.28
0.1036 1 0.5
0.0708 0.3228 0.5501
0.2124 1 1
0.0308 0.5725 1
0.0369 0.5351 1
0.0308 0.382 1
0.4584 0.4255 0.5845
0.263 0.5923 0.8317
0.3329 0.2526 1
0.0306 0.547 1
0.0677 1 1
0.1919 1 1
0.5621 0.6051 1
0.3336 1 0.5
0.2304 0.4952 1
0.0636 0.3197 1
0.0383 0.4674 1
0.3697 1 0.5
0.0659 0.4539 1
0.2156 1 1
0.5806 1 0.5
0.1023 0.4899 1
0.5644 0.8356 1
0.0383 1 0.5
0.0955 1 1
0.0766 0.3101 1
0.0766 1 0.5
0.2309 1 1
0.641 1 0.5
0.8226 1 1
0.0369 0.2876 1
0.0672 0.8949 1
0.0373 1 1
0.1245 0.5876 0.5876
0.1064 1 1
0.0306 1 1
0.1264 0.2835 0.3041
0.1899 1 0.5
0.8226 1 1
0.3739 0.4903 1
0.0317 0.4337 1
0.2501 0.6346 0.5
0.1667 0.2604 0.28
0.6515 0.5949 0.9007
0.3609 0.7368 1
0.0698 0.3665 0.3665
0.0691 0.6027 1
0.16 0.6259 1
0.0996 0.7486 1
0.6122 1 1
0.0655 0.5243 1
0.2196 0.5 0.5
0.2634 0.8 1
0.0351 0.3421 1
0.1555 1 1
0.0383 1 0.5
0.1684 0.3792 1
0.0351 0.4248 1
0.5097 1 1
0.0708 0.5532 0.553
0.0639 1 1
0.4616 1 0.5
0.263 0.5923 0.8317
0.062 0.2997 0.2997
0.0732 0.3447 0.5
0.2812 1 1
0.0383 0.5598 0.5
0.1383 0.4617 0.4596
0.0652 0.7608 1
0.0956 0.4487 0.4834
0.0383 0.4868 1
0.0654 0.7347 1
0.0369 0.2876 1
0.1261 1 1
0.7289 1 1
0.1601 0.3138 0.3375
0.1006 0.4376 1
0.0939 0.6095 1
0.1259 0.3468 1
0.391 1 1
0.0352 0.6669 1
0.263 0.5923 0.8317
0.0383 0.4412 1
0.0627 0.7156 0.7688
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0.1312 0.3065 0.5
0.0355 0.2725 1
0.4842 0.2981 0.5033
0.4858 1 1
0.0383 0.4956 1
0.1612 0.2801 0.3009
0.7886 1 0.5
0.0999 0.5437 1
0.8226 1 1
0.0936508 0.277999 0.253229
0.0965 1 0.5
0.3995 1 1
0.5644 0.8356 1
0.0383 0.5 0.5
0.1032 1 0.5
0.0973 1 0.5
0.0618 0.6246 1
0.4584 0.4255 0.5845
0.5172 1 0.5
0.0348 0.6996 1
0.0383 1 0.5
0.3811 0.4714 1
0.2224 1 1
0.0243 0.4993 1
0.2539 0.6656 1
0.0255 0.2567 1
0.6515 0.5949 0.9007
0.2304 0.4952 1
0.0312 0.379 1
0.0383 0.2587 0.5
0.8226 1 1
0.4842 0.2981 0.5033
0.4602 1 0.5
0.6119 0.3491 0.3489

Assayability

Assay information

  • Inhibitory activity against FabH from Mycobacterium tuberculosis H37Rv ChEMBL
  • Inhibitory activity against FabH from Mycobacterium tuberculosis H37Rv
  • Inhibitory activity against KasA from Mycobacterium tuberculosis H37Rv ChEMBL
  • Inhibitory activity against KasA from Mycobacterium tuberculosis H37Rv
  • Inhibitory activity against FabH from Mycobacterium tuberculosis H37Rv at 100 uM ChEMBL
  • Inhibitory activity against FabH from Mycobacterium tuberculosis H37Rv at 100 uM
  • Inhibition of Mycobacterium tuberculosis FabH at 100 uM ChEMBL
  • Inhibition of Mycobacterium tuberculosis FabH at 100 uM
  • Inhibition of Mycobacterium tuberculosis FabH ChEMBL
  • Inhibition of Mycobacterium tuberculosis FabH
  • In vitro inhibitory activity against the recombinant Mycobacterium tuberculosis Beta-ketoacyl-ACP synthase III mtFabH condensing enzyme. ChEMBL
  • In vitro inhibitory activity against the recombinant Mycobacterium tuberculosis Beta-ketoacyl-ACP synthase III mtFabH condensing enzyme.
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis FabH
  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Mycobacterium tuberculosis ( 3 )

Reagent availability

  • Reagent:
  • Target Type Source Notes
    Rv0533c cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 3 )

Bibliographic References

30 literature references were collected for this gene.

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Gene identifier Rv0533c (Mycobacterium tuberculosis), 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)
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