Detailed view for EHI_084260

Basic information

TDR Targets ID: 799423
Entamoeba histolytica, 1-Cys peroxiredoxin, putative
Source Database / ID:  AmoebaDB  

pI: 6.6336 | Length (AA): 217 | MW (Da): 24551 | Paralog Number: 518

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00578   AhpC/TSA family
PF10417   C-terminal domain of 1-Cys peroxiredoxin

Gene Ontology

Mouse over links to read term descriptions.
GO:0051920   peroxiredoxin activity  
GO:0016491   oxidoreductase activity  
GO:0016209   antioxidant activity  
GO:0055114   oxidation reduction  
GO:0045454   cell redox homeostasis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Trophozoite. Hon CC
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Schistosoma mansoni thioredoxin peroxidase 185 aa 44.3% 176 aa Compounds References
Mycobacterium leprae ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C) 195 aa 27.5% 171 aa Compounds References
Mycobacterium tuberculosis Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) 195 aa 29.6% 169 aa Compounds References
Trypanosoma cruzi tryparedoxin peroxidase 199 aa 39.6% 192 aa Compounds References
Trypanosoma cruzi tryparedoxin peroxidase, putative 199 aa 39.1% 192 aa Compounds References
Trypanosoma cruzi tryparedoxin peroxidase, putative 199 aa 39.1% 192 aa Compounds References
Trypanosoma cruzi tryparedoxin peroxidase, putative 199 aa 39.1% 192 aa Compounds References
Trypanosoma cruzi tryparedoxin peroxidase, putative 199 aa 39.1% 192 aa Compounds References
Trypanosoma cruzi tryparedoxin peroxidase, putative 199 aa 39.1% 192 aa Compounds References
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0192 0.4617 0.4617

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_084260 (Entamoeba histolytica), 1-Cys peroxiredoxin, putative
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