Detailed view for EHI_117570

Basic information

TDR Targets ID: 801397
Entamoeba histolytica, serine/threonine protein phosphatase, putative
Source Database / ID:  AmoebaDB  

pI: 4.7173 | Length (AA): 433 | MW (Da): 48940 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 393 4ja7 (A) 89 486 33.00 0 1 1.37702 -0.85
1 393 5jjt (A) 74 472 36.00 0 1 1.38202 -0.6
86 386 4i5l (C) 3 292 34.00 0 1 1.21515 -1.46
133 427 4or9 (A) 85 422 35.00 0 1 1.04169 -0.46
141 210 1g5b (A) 14 77 45.00 0.00023 1 0.650563 -0.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_131440)

Species Accession Gene Product
Brugia malayi Bm1_03005   Ser/Thr protein phosphatase family protein
Caenorhabditis elegans CELE_F23H11.8   Protein PEF-1, isoform C
Drosophila melanogaster Dmel_CG44746   retinal degeneration C
Echinococcus granulosus EgrG_000211200   serine:threonine protein phosphatase with
Entamoeba histolytica EHI_117570   serine/threonine protein phosphatase, putative
Echinococcus multilocularis EmuJ_000211200   serine:threonine protein phosphatase with
Homo sapiens ENSG00000156194   protein phosphatase, EF-hand calcium binding domain 2
Homo sapiens ENSG00000086717   protein phosphatase, EF-hand calcium binding domain 1
Loa Loa (eye worm) LOAG_14099   hypothetical protein
Loa Loa (eye worm) LOAG_06253   phosphatase with ef hands protein 1
Mus musculus ENSMUSG00000062168   protein phosphatase with EF hand calcium-binding domain 1
Mus musculus ENSMUSG00000029410   protein phosphatase, EF hand calcium-binding domain 2
Schistosoma japonicum Sjp_0005750   ko:K01090 protein phosphatase [EC3.1.3.16], putative
Schistosoma japonicum Sjp_0095750   Serine/threonine-protein phosphatase with EF-hands 1, putative
Schistosoma mansoni Smp_140770   protein phosphatase-7
Schmidtea mediterranea mk4.005482.02  
Schmidtea mediterranea mk4.013371.00   Serine/threonine-protein phosphatase rdgC
Schmidtea mediterranea mk4.021878.01  
Schmidtea mediterranea mk4.021878.02   Serine/threonine-protein phosphatase rdgC
Schmidtea mediterranea mk4.023905.00   Serine/threonine-protein phosphatase rdgC
Schmidtea mediterranea mk4.001594.00  
Schmidtea mediterranea mk4.010835.03   Serine/threonine-protein phosphatase rdgC
Schmidtea mediterranea mk4.013959.01  
Schmidtea mediterranea mk4.013959.00   Serine/threonine-protein phosphatase rdgC

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 169 aa 33.3% 159 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 297 aa 35.7% 241 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 beta 330 aa 34.3% 280 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 294 aa 35.7% 241 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 294 aa 35.7% 241 aa Compounds References
Bos taurus Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform 309 aa 34.3% 306 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 294 aa 35.7% 241 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 159 aa 35.3% 150 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_117570 (Entamoeba histolytica), serine/threonine protein phosphatase, putative
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