Detailed view for GL50803_15984

Basic information

TDR Targets ID: 805892
Giardia lamblia, Impact-like protein
Source Database / ID:  GiardiaDB  

pI: 5.1791 | Length (AA): 276 | MW (Da): 30612 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01205   Uncharacterized protein family UPF0029

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 105 2ebk (A) 12 120 12.00 0.000000075 0.16 0.415535 -0.2
1 112 2dmf (A) 13 131 10.00 0.000000000071 0.18 0.430897 -0.28
154 266 2cve (A) 16 120 33.00 0 1 0.66832 0.06
154 247 1vi7 (A) 21 112 38.00 0.00018 1 0.65678 0.79
154 247 2cve (A) 16 100 41.00 0.00083 0.75 0.58778 0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129517)

Species Accession Gene Product
Candida albicans CaO19.3273   similar to S. cerevisiae YCR059C involved in regulation of amino acid metabolsm
Candida albicans CaO19.3274   general amino acid control pathway
Candida albicans CaO19.10784   general amino acid control pathway
Candida albicans CaO19.10783   similar to S. cerevisiae YCR059C involved in regulation of amino acid metabolsm
Caenorhabditis elegans CELE_Y52B11A.2   Protein Y52B11A.2, isoform B
Cryptosporidium parvum cgd2_2430   ximpact ortholog conserved protein seen in bacteria and eukaryotes
Dictyostelium discoideum DDB_G0287757   hypothetical protein
Echinococcus granulosus EgrG_000983600   protein IMPACT
Entamoeba histolytica EHI_013300   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000983600   protein IMPACT
Giardia lamblia GL50803_15984   Impact-like protein
Homo sapiens ENSG00000154059   impact RWD domain protein
Leishmania braziliensis LbrM.35.5190   hypothetical protein, conserved
Leishmania donovani LdBPK_365170.1   Uncharacterized protein family UPF0029, putative
Leishmania infantum LinJ.36.5170   hypothetical protein, conserved
Leishmania major LmjF.36.4940   hypothetical protein, conserved
Leishmania mexicana LmxM.36.4940   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_15784   hypothetical protein
Loa Loa (eye worm) LOAG_14972   hypothetical protein
Mus musculus ENSMUSG00000024423   impact, RWD domain protein
Onchocerca volvulus OVOC3400  
Saccharomyces cerevisiae YCR059C   Yih1p
Schistosoma japonicum Sjp_0135010   IPR001498,Protein of unknown function UPF0029;IPR006575,RWD,domain-containing
Schistosoma japonicum Sjp_0210280   Protein IMPACT-A, putative
Schistosoma japonicum Sjp_0057040   IPR001498,Protein of unknown function UPF0029;IPR006575,RWD,domain-containing
Schistosoma japonicum Sjp_0119610   IPR006575,RWD,domain-containing
Schistosoma mansoni Smp_029370   hypothetical protein
Schmidtea mediterranea mk4.006384.00   Protein IMPACT homolog
Trypanosoma brucei gambiense Tbg972.11.12300   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.10970   RWD domain/Uncharacterized protein family UPF0029, putative
Trypanosoma congolense TcIL3000.11.11690   RWD domain/Uncharacterized protein family UPF0029, putative
Trypanosoma cruzi TcCLB.508269.10   RWD domain/Uncharacterized protein family UPF0029, putative
Trypanosoma cruzi TcCLB.503971.20   RWD domain/Uncharacterized protein family UPF0029, putative
Trichomonas vaginalis TVAG_291410   impact, putative

Essentiality

GL50803_15984 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.2750 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.2750 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.2750 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.2750 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_15984 (Giardia lamblia), Impact-like protein
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