pI: 9.7817 |
Length (AA): 1118 |
MW (Da): 123448 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
483 | 635 | 2mtd (A) | 27 | 179 | 18.00 | 0 | 0.43 | 0.360752 | -0.29 |
749 | 975 | 4d81 (A) | 99 | 289 | 29.00 | 0.0000000057 | 1 | 0.284741 | -0.03 |
751 | 1024 | 3b9p (A) | 484 | 726 | 32.00 | 0.00000000024 | 1 | 0.31078 | 0.53 |
751 | 854 | 5w0t (A) | 92 | 198 | 30.00 | 0.000028 | 0.81 | 0.422723 | 0 |
784 | 903 | 2dhr (A) | 192 | 309 | 28.00 | 0.037 | 0.59 | 0.390035 | -0.15 |
784 | 984 | 3h4m (A) | 207 | 370 | 37.00 | 0.0000000092 | 1 | 0.186485 | 1.02 |
784 | 858 | 3whl (A) | 218 | 303 | 37.00 | 0.016 | 0.3 | 0.224784 | 1.21 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129551)
Species | Accession | Gene Product |
---|---|---|
Drosophila melanogaster | Dmel_CG16789 | CG16789 gene product from transcript CG16789-RA |
Drosophila melanogaster | Dmel_CG14183 | CG14183 gene product from transcript CG14183-RA |
Echinococcus granulosus | EgrG_001013100 | IQ and AAA domain containing protein 1 |
Echinococcus multilocularis | EmuJ_001013100 | IQ and AAA domain containing protein 1 |
Giardia lamblia | GL50803_94322 | Spastin |
Homo sapiens | ENSG00000132321 | IQ motif containing with AAA domain 1 |
Homo sapiens | 102723607 | putative IQ and AAA domain-containing protein 1-like |
Leishmania braziliensis | LbrM.13.1280 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_131580.1 | ATPase family associated with various cellular activities (AAA), putative |
Leishmania infantum | LinJ.13.1580 | hypothetical protein, conserved |
Leishmania major | LmjF.13.1520 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.13.1520 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000026301 | IQ motif containing with AAA domain |
Mus musculus | ENSMUSG00000038199 | RIKEN cDNA 4931409K22 gene |
Neospora caninum | NCLIV_011810 | AAA family ATPase domain-containing protein, putative |
Schistosoma japonicum | Sjp_0006740 | IQ and AAA domain-containing protein, putative |
Schistosoma japonicum | Sjp_0006750 | IQ and AAA domain-containing protein, putative |
Schistosoma mansoni | Smp_013080 | hypothetical protein |
Schmidtea mediterranea | mk4.000317.00 | |
Trypanosoma brucei gambiense | Tbg972.11.3800 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.3360 | Component of motile flagella 22 |
Trypanosoma congolense | TcIL3000_0_10780 | ATPase family associated with various cellular activities (AAA), putative |
Trypanosoma congolense | TcIL3000.11.3230 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.507099.10 | ATPase family associated with various cellular activities (AAA), putative |
Trypanosoma cruzi | TcCLB.503999.110 | ATPase family associated with various cellular activities (AAA), putative |
Toxoplasma gondii | TGME49_211050 | ATPase, AAA family protein |
Trichomonas vaginalis | TVAG_493270 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.0860 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.0860 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.0860 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.0860 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_211050 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.