Detailed view for GL50803_14403

Basic information

TDR Targets ID: 811076
Giardia lamblia, Lysophosphatidic acid acyltransferase, putative
Source Database / ID:  GiardiaDB  

pI: 8.4336 | Length (AA): 433 | MW (Da): 49698 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01553   Acyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016746   transferase activity, transferring acyl groups  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
152 323 5kym (A) 13 188 29.00 0.07 0.57 0.476129 0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129480)

Species Accession Gene Product
Arabidopsis thaliana AT5G60620   glycerol-3-phosphate acyltransferase 9
Brugia malayi Bm1_40295   Acyltransferase-like protein 4
Caenorhabditis elegans CELE_F49H12.6   Protein ACL-4, isoform B
Caenorhabditis elegans CELE_R07E3.5   Protein ACL-5, isoform B
Dictyostelium discoideum DDB_G0274969   phospholipid/glycerol acyltransferase
Drosophila melanogaster Dmel_CG3209   CG3209 gene product from transcript CG3209-RE
Echinococcus multilocularis EmuJ_000573200   glycerol 3 phosphate acyltransferase 3
Giardia lamblia GL50803_14403   Lysophosphatidic acid acyltransferase, putative
Homo sapiens ENSG00000158669   1-acylglycerol-3-phosphate O-acyltransferase 6
Homo sapiens ENSG00000138678   1-acylglycerol-3-phosphate O-acyltransferase 9
Loa Loa (eye worm) LOAG_06144   ACL-5 protein
Mus musculus ENSMUSG00000029314   1-acylglycerol-3-phosphate O-acyltransferase 9
Mus musculus ENSMUSG00000031545   1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
Oryza sativa 4343455   Os07g0531600
Schistosoma japonicum Sjp_0106030   hypothetical protein
Schistosoma japonicum Sjp_0313500   expressed protein
Schistosoma japonicum Sjp_0121170   hypothetical protein
Schistosoma japonicum Sjp_0003510   ko:K00655 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC2.3.1.51], putative
Schistosoma mansoni Smp_145060   acyl-CoA:glycerol-3-phosphate acyltransferase
Schmidtea mediterranea mk4.000195.08  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0006 0.5 0.5
0.0006 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_14403 (Giardia lamblia), Lysophosphatidic acid acyltransferase, putative
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