Detailed view for GL50803_11052

Basic information

TDR Targets ID: 814322
Giardia lamblia, Zinc finger domain
Source Database / ID:  GiardiaDB  

pI: 7.0636 | Length (AA): 278 | MW (Da): 30040 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13920   Zinc finger, C3HC4 type (RING finger)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
185 262 3lrq (A) 0 78 23.00 0.14 0.5 0.552276 -0.1
191 266 2csy (A) 9 80 26.00 0.68 0.97 0.572081 0
200 244 1rmd (A) 26 70 29.00 0 0.72 0.384171 0.85
200 263 2csy (A) 18 81 28.00 0.043 0.75 0.492316 0.51
200 246 4auq (B) 252 293 38.00 0.0045 1 0.468165 0.59
200 244 4gb0 (A) 16 60 44.00 0.0057 0.99 0.613971 0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128926)

Species Accession Gene Product
Arabidopsis thaliana AT3G53410   probable E3 ubiquitin-protein ligase LUL2
Arabidopsis thaliana AT3G06140   probable E3 ubiquitin-protein ligase LUL4
Arabidopsis thaliana AT3G09770   probable E3 ubiquitin-protein ligase LOG2
Arabidopsis thaliana AT5G19080   probable E3 ubiquitin-protein ligase LUL3
Babesia bovis BBOV_IV012000   hypothetical protein
Brugia malayi Bm1_03585   hypothetical protein
Caenorhabditis elegans CELE_C11H1.3   Protein C11H1.3
Cryptosporidium hominis Chro.30158   B1045D11.20
Cryptosporidium parvum cgd3_1260   RING domain protein
Dictyostelium discoideum DDB_G0269704   hypothetical protein
Drosophila melanogaster Dmel_CG9941   CG9941 gene product from transcript CG9941-RA
Giardia lamblia GL50803_11052   Zinc finger domain
Homo sapiens ENSG00000102858   mahogunin ring finger 1, E3 ubiquitin protein ligase
Homo sapiens ENSG00000141576   ring finger protein 157
Loa Loa (eye worm) LOAG_14622   hypothetical protein
Loa Loa (eye worm) LOAG_09645   hypothetical protein
Mus musculus ENSMUSG00000022517   mahogunin, ring finger 1
Mus musculus ENSMUSG00000052949   ring finger protein 157
Neospora caninum NCLIV_038740   hypothetical protein
Oryza sativa 4348266   Os10g0204100
Oryza sativa 4332287   Os03g0254900
Oryza sativa 9266835   Os05g0397650
Onchocerca volvulus OVOC4056  
Plasmodium berghei PBANKA_0311900   RING zinc finger protein, putative
Plasmodium falciparum PF3D7_0215100   RING zinc finger protein, putative
Plasmodium knowlesi PKNH_0405700   RING zinc finger protein, putative
Plasmodium vivax PVX_002780   RING zinc finger protein, putative
Plasmodium yoelii PY00197   hypothetical protein
Schmidtea mediterranea mk4.000361.28  
Toxoplasma gondii TGME49_267440   RING zinc finger protein
Theileria parva TP01_1110   hypothetical protein

Essentiality

GL50803_11052 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C11H1.3 Caenorhabditis elegans adult lethal wormbase
CELE_C11H1.3 Caenorhabditis elegans slow growth wormbase
PBANKA_0311900 Plasmodium berghei Slow plasmo
TGME49_267440 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_11052 (Giardia lamblia), Zinc finger domain
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