Detailed view for GL50803_2933

Basic information

TDR Targets ID: 814524
Giardia lamblia, Programmed cell death protein-like protein
Source Database / ID:  GiardiaDB  

pI: 5.8797 | Length (AA): 180 | MW (Da): 19960 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13405   EF-hand domain
PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 177 3sib (A) 38 218 20.00 0 1 1.30631 -1.24
13 141 5d43 (A) 26 163 29.00 0.0000033 1 1.09977 -0.62
13 171 1y1x (A) 22 182 29.00 0 1 1.31253 -0.73
85 141 2m97 (A) 6 62 23.00 0.045 0.6 0.743767 -1.46
100 144 4c89 (A) 256 299 43.00 0.92 0.31 0.6461 0.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127426)

Species Accession Gene Product
Arabidopsis thaliana AT3G10300   putative calcium-binding protein CML49
Arabidopsis thaliana AT5G04170   putative calcium-binding protein CML50
Arabidopsis thaliana AT2G27480   putative calcium-binding protein CML48
Brugia malayi Bm1_07185   programmed cell death protein 6
Candida albicans CaO19.2180   similar to S. cerevisiae YGR058W
Candida albicans CaO19.9726   similar to S. cerevisiae YGR058W
Caenorhabditis elegans CELE_M04F3.4   Protein M04F3.4, isoform A
Dictyostelium discoideum DDB_G0293530   penta EF hand calcium binding protein
Dictyostelium discoideum DDB_G0291081   penta EF hand calcium binding protein
Drosophila melanogaster Dmel_CG17765   CG17765 gene product from transcript CG17765-RA
Drosophila melanogaster Dmel_CG40410   Apoptosis-linked gene-2
Echinococcus granulosus EgrG_000715700   programmed cell death protein 6
Echinococcus granulosus EgrG_000925800   programmed cell death protein
Entamoeba histolytica EHI_167310   grainin 2
Entamoeba histolytica EHI_120360   grainin, putative
Echinococcus multilocularis EmuJ_000025200   programmed cell death protein
Echinococcus multilocularis EmuJ_000925800   programmed cell death protein
Echinococcus multilocularis EmuJ_000715700   programmed cell death protein 6
Giardia lamblia GL50803_2933   Programmed cell death protein-like protein
Homo sapiens ENSG00000249915   programmed cell death 6
Homo sapiens ENSG00000162517   penta-EF-hand domain containing 1
Leishmania braziliensis LbrM.13.1220   programmed cell death 6 protein-like protein
Leishmania donovani LdBPK_131500.1   programmed cell death 6 protein-like protein
Leishmania infantum LinJ.13.1500   programmed cell death 6 protein-like protein
Leishmania major LmjF.13.1460   programmed cell death 6 protein-like protein
Leishmania mexicana LmxM.13.1460   programmed cell death 6 protein-like protein
Loa Loa (eye worm) LOAG_12256   programmed cell death protein 6
Mus musculus ENSMUSG00000021576   programmed cell death 6
Mus musculus ENSMUSG00000028779   penta-EF hand domain containing 1
Oryza sativa 4351450   Os12g0137100
Oryza sativa 4346304   Os08g0558100
Oryza sativa 4349736   Os11g0140600
Onchocerca volvulus OVOC7576  
Saccharomyces cerevisiae YGR058W   Pef1p
Schistosoma japonicum Sjp_0052430   Sorcin, putative
Schistosoma japonicum Sjp_0092340   Sorcin, putative
Schistosoma japonicum Sjp_0052420   Sorcin, putative
Schistosoma mansoni Smp_136640   programmed cell death protein
Schistosoma mansoni Smp_067490   programmed cell death protein
Schistosoma mansoni Smp_067480.1   programmed cell death protein
Schistosoma mansoni Smp_067480.2   programmed cell death protein
Schistosoma mansoni Smp_067480.3   programmed cell death protein
Schmidtea mediterranea mk4.000083.01  
Schmidtea mediterranea mk4.000097.04   Programmed cell death protein 6
Schmidtea mediterranea mk4.004775.03   Programmed cell death protein 6
Trypanosoma cruzi TcCLB.507099.50   programmed cell death 6 protein-like, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Calmodulin 149 aa 25.5% 141 aa Compounds References
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0016 0.2966 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_2933 (Giardia lamblia), Programmed cell death protein-like protein
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