pI: 6.9084 |
Length (AA): 1472 |
MW (Da): 166961 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
52 | 654 | 2a3l (A) | 212 | 827 | 29.00 | 0 | 1 | 0.767647 | -0.12 |
708 | 1282 | 2a3l (A) | 246 | 826 | 43.00 | 0 | 1 | 0.926325 | -0.54 |
1220 | 1426 | 5cwp (A) | 13 | 225 | 13.00 | 0.21 | 0.01 | 0.296625 | -0.89 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126856)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G38280 | AMP deaminase |
Brugia malayi | Bm1_54650 | adenosine monophosphate deaminase |
Candida albicans | CaO19.8510 | Adenosine/AMP deaminase similar to S. cerevisiae AMD1 (YML035C) involved in purine nucleotide metabolism |
Candida albicans | CaO19.891 | Adenosine/AMP deaminase similar to S. cerevisiae AMD1 (YML035C) involved in purine nucleotide metabolism |
Caenorhabditis elegans | CELE_C34F11.3 | Protein C34F11.3, isoform B |
Cryptosporidium hominis | Chro.40214 | AMP deaminase |
Cryptosporidium parvum | cgd4_1890 | adenosine monophosphate deaminase 2 |
Dictyostelium discoideum | DDB_G0292266 | AMP deaminase |
Drosophila melanogaster | Dmel_CG32626 | AMP deaminase |
Echinococcus granulosus | EgrG_000392900 | AMP deaminase 2 |
Entamoeba histolytica | EHI_029100 | AMP deaminase, putative |
Entamoeba histolytica | EHI_120890 | AMP deaminase, putative |
Echinococcus multilocularis | EmuJ_000392900 | AMP deaminase 2 |
Homo sapiens | ENSG00000133805 | adenosine monophosphate deaminase 3 |
Homo sapiens | ENSG00000116748 | adenosine monophosphate deaminase 1 |
Homo sapiens | ENSG00000116337 | adenosine monophosphate deaminase 2 |
Leishmania braziliensis | LbrM.04.0320 | adenosine monophosphate deaminase, putative,AMP deaminase, putative |
Leishmania braziliensis | LbrM.32.2780 | AMP deaminase, putative,adenosine monophosphate deaminase-like protein |
Leishmania braziliensis | LbrM.34.4760 | AMP deaminase, putative |
Leishmania braziliensis | LbrM.13.0790 | AMP deaminase, putative,amp deaminase-like protein |
Leishmania donovani | LdBPK_322690.1 | AMP deaminase, putative |
Leishmania donovani | LdBPK_040270.1 | adenosine monophosphate deaminase, putative |
Leishmania donovani | LdBPK_354860.1 | AMP deaminase, putative |
Leishmania donovani | LdBPK_130870.1 | AMP deaminase, putative |
Leishmania infantum | LinJ.32.2690 | AMP deaminase, putative,adenosine monophosphate deaminase-like protein |
Leishmania infantum | LinJ.35.4860 | AMP deaminase, putative |
Leishmania infantum | LinJ.04.0270 | adenosine monophosphate deaminase, putative,AMP deaminase, putative |
Leishmania infantum | LinJ.13.0870 | AMP deaminase, putative,amp deaminase-like protein |
Leishmania major | LmjF.13.0980 | AMP deaminase, putative,amp deaminase-like protein |
Leishmania major | LmjF.32.2550 | AMP deaminase, putative,adenosine monophosphate deaminase-like protein |
Leishmania major | LmjF.35.4800 | AMP deaminase, putative |
Leishmania major | LmjF.04.0280 | adenosine monophosphate deaminase, putative,AMP deaminase, putative |
Leishmania mexicana | LmxM.13.0980 | AMP deaminase, putative,amp deaminase-like protein |
Leishmania mexicana | LmxM.31.2550 | AMP deaminase, putative,adenosine monophosphate deaminase-like protein |
Leishmania mexicana | LmxM.04.0280 | adenosine monophosphate deaminase, putative,AMP deaminase, putative |
Leishmania mexicana | LmxM.34.4800 | AMP deaminase, putative |
Loa Loa (eye worm) | LOAG_06535 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06536 | AMP deaminase |
Mus musculus | ENSMUSG00000070385 | adenosine monophosphate deaminase 1 |
Mus musculus | ENSMUSG00000005686 | adenosine monophosphate deaminase 3 |
Mus musculus | ENSMUSG00000027889 | adenosine monophosphate deaminase 2 |
Neospora caninum | NCLIV_049460 | adenosine monophosphate deaminase, putative |
Oryza sativa | 4344386 | Os07g0693500 |
Oryza sativa | 4338495 | Os05g0349200 |
Onchocerca volvulus | OVOC3634 | AMP deaminase 2 homolog |
Plasmodium berghei | PBANKA_1344400 | AMP deaminase, putative |
Plasmodium falciparum | PF3D7_1329400 | AMP deaminase, putative |
Plasmodium knowlesi | PKNH_1271000 | AMP deaminase, putative |
Plasmodium vivax | PVX_082415 | adenosine/AMP deaminase, putative |
Plasmodium yoelii | PY01044 | AMP deaminase homolog |
Saccharomyces cerevisiae | YML035C | AMP deaminase |
Schistosoma japonicum | Sjp_0036970 | ko:K01490 AMP deaminase [EC3.5.4.6], putative |
Schistosoma japonicum | Sjp_0121980 | AMP deaminase 2, putative |
Schistosoma mansoni | Smp_004120 | AMP deaminase |
Schmidtea mediterranea | mk4.006992.03 | AMP deaminase 2 |
Schmidtea mediterranea | mk4.022116.01 | |
Schmidtea mediterranea | mk4.007268.02 | AMP deaminase 2 |
Schmidtea mediterranea | mk4.025763.00 | |
Schmidtea mediterranea | mk4.000649.05 | Adenosine monophosphate deaminase 1 |
Schmidtea mediterranea | mk4.016439.04 | Adenosine monophosphate deaminase 1 |
Schmidtea mediterranea | mk4.000135.03 | AMP deaminase 2 |
Trypanosoma brucei gambiense | Tbg972.11.17670 | AMP deaminase, putative |
Trypanosoma brucei gambiense | Tbg972.9.3860 | adenosine monophosphate deaminase, putative,AMP deaminase, putative |
Trypanosoma brucei gambiense | Tbg972.9.5600 | AMP deaminase, putative |
Trypanosoma brucei gambiense | Tbg972.11.4470 | AMP deaminase, putative |
Trypanosoma brucei | Tb927.9.7180 | adenosine monophosphate deaminase, putative |
Trypanosoma brucei | Tb927.11.15750 | AMP deaminase, putative |
Trypanosoma brucei | Tb927.9.9740 | AMP deaminase, putative |
Trypanosoma brucei | Tb927.11.3850 | AMP deaminase, putative |
Trypanosoma congolense | TcIL3000.11.3800 | AMP deaminase, putative |
Trypanosoma congolense | TcIL3000_0_53780 | adenosine monophosphate deaminase, putative |
Trypanosoma congolense | TcIL3000_9_3570 | AMP deaminase, putative |
Trypanosoma congolense | TcIL3000_9_2410 | adenosine monophosphate deaminase, putative |
Trypanosoma cruzi | TcCLB.506733.20 | AMP deaminase, putative |
Trypanosoma cruzi | TcCLB.410589.10 | AMP deaminase, putative |
Trypanosoma cruzi | TcCLB.511857.80 | AMP deaminase, putative |
Trypanosoma cruzi | TcCLB.461927.9 | adenosine monophosphate deaminase, putative |
Trypanosoma cruzi | TcCLB.506885.390 | AMP deaminase, putative |
Trypanosoma cruzi | TcCLB.510729.10 | AMP deaminase, putative |
Trypanosoma cruzi | TcCLB.508273.10 | adenosine monophosphate deaminase-like protein, putative |
Toxoplasma gondii | TGME49_234280 | AMP deaminase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.1340 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.1340 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.1340 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.1340 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb09.211.1320 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.1320 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.1320 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.211.1320 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb09.160.5250 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.5250 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.5250 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.5250 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.01.7390 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.7390 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.7390 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.7390 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C34F11.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C34F11.3 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_234280 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | adenosine monophosphate deaminase 1 | Compounds | References |
Homo sapiens | adenosine monophosphate deaminase 3 | Compounds | References |
Oryctolagus cuniculus | AMP deaminase 1 | Compounds | References |
Trypanosoma brucei | AMP deaminase, putative | Compounds | References |
Arabidopsis thaliana | AMP deaminase | Compounds | References |
Trypanosoma brucei | AMP deaminase, putative | Compounds | References |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | Compounds | References |
Trypanosoma brucei | AMP deaminase, putative | Compounds | References |
Homo sapiens | adenosine monophosphate deaminase 2 | Compounds | References |