pI: 8.6119 |
Length (AA): 324 |
MW (Da): 37685 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 324 | 3hx4 (A) | 40 | 320 | 31.00 | 0 | 1 | 1.0853 | 0.76 |
2 | 41 | 3dls (A) | 992 | 1030 | 33.00 | 0 | 0.84 | 0.416357 | 0.22 |
7 | 310 | 1ob3 (A) | 2 | 286 | 46.00 | 0 | 1 | 1.36157 | 0.08 |
12 | 321 | 1ua2 (A) | 14 | 308 | 44.00 | 0 | 1 | 1.37509 | 0.03 |
110 | 185 | 4oau (C) | 458 | 534 | 30.00 | 0.7 | 0.71 | 0.630968 | -0.51 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Erthyrocytic stages. | Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Ookinete, 16 hs Trophozoite. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | 4 hs Ring, Female gametocyte, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Gametocyte, 22 hs Schizont. | Otto TD |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_141009)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_IV010230 | cyclin-dependent kinase-related kinase, putative |
Cryptosporidium hominis | Chro.70056 | cyclin-dependent kinase-related kinase |
Cryptosporidium parvum | cgd7_430 | cyclin-dependent kinase-related kinase, putative |
Neospora caninum | NCLIV_036330 | CAM kinase, CDPK family, putative |
Plasmodium berghei | PBANKA_1212800 | MO15-related protein kinase |
Plasmodium falciparum | PF3D7_1014400 | MO15-related protein kinase |
Plasmodium knowlesi | PKNH_0814500 | MO15-related protein kinase |
Plasmodium vivax | PVX_094935 | cyclin dependent kinase 7 (cdk7), putative |
Plasmodium yoelii | PY05139 | MO15-related protein kinase Pfmrk |
Toxoplasma gondii | TGME49_270330 | cell-cycle-associated protein kinase, putative |
Theileria parva | TP01_0781 | cyclin-dependent kinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1212800 this record | Plasmodium berghei | Essential | plasmo |
TGME49_270330 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | MO15-related protein kinase | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 37.4% | 297 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 44.1% | 295 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 36.5% | 296 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 40.9% | 296 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 36.5% | 181 aa | Compounds | References |