Detailed view for TP02_0140

Basic information

TDR Targets ID: 833996
Theileria parva, cysteine proteinase, putative
Source Database / ID: 

pI: 7.288 | Length (AA): 440 | MW (Da): 50027 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00112   Papain family cysteine protease
PF08246   Cathepsin propeptide inhibitor domain (I29)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
141 440 1cs8 (A) 1 219 26.00 0 1 0.936818 -0.25
148 218 3f75 (P) 109 178 36.00 0 0.48 0.671364 -1.36
149 438 1pci (A) 16 212 31.00 0 1 1.02929 -0.3
156 416 1xkg (A) 8 281 24.00 0 1 0.835382 -0.02
238 440 3p5u (A) 2 216 31.00 0 1 0.875564 -0.94
238 438 1fh0 (A) 2 217 33.00 0 1 0.820018 -0.73
368 416 2wbf (X) 744 798 37.00 0.09 0.09 0.241564 1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_171239)

Species Accession Gene Product
Schistosoma japonicum Sjp_0014320   Cathepsin K precursor, putative
Schistosoma mansoni Smp_139240   cathepsin S (C01 family)
Theileria parva TP02_0140   cysteine proteinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Canis familiaris Cathepsin K 330 aa 29.4% 316 aa Compounds References
Rattus norvegicus Cathepsin B 339 aa 22.6% 305 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 28.1% 306 aa Compounds References
Rattus norvegicus Cathepsin S 330 aa 27.7% 285 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 28.0% 311 aa Compounds References
Capra hircus Cathepsin H 335 aa 27.5% 316 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 28.0% 311 aa Compounds References
Rattus norvegicus Cathepsin K 329 aa 28.3% 325 aa Compounds References
Carica papaya Papain 345 aa 29.0% 307 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 27.6% 311 aa Compounds References
Rattus norvegicus Cathepsin L 334 aa 26.1% 337 aa Compounds References
Oryctolagus cuniculus Cathepsin K 329 aa 28.5% 330 aa Compounds References
Bos taurus Cathepsin L 334 aa 27.4% 274 aa Compounds References
Leishmania major cysteine peptidase A (CPA) 354 aa 27.3% 308 aa Compounds References
Dermatophagoides pteronyssinus Peptidase 1 320 aa 22.2% 288 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 27.6% 311 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TP02_0140 (Theileria parva), cysteine proteinase, putative
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