Detailed view for TVAG_219530

Basic information

TDR Targets ID: 837993
Trichomonas vaginalis, copine, putative
Source Database / ID: 

pI: 6.7503 | Length (AA): 480 | MW (Da): 54158 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF07002   Copine

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127123)

Species Accession Gene Product
Arabidopsis thaliana AT5G07300   protein BONZAI 2
Arabidopsis thaliana AT1G08860   protein BONZAI 3
Arabidopsis thaliana AT5G61900   copine-like protein BONZAI 1
Brugia malayi Bm1_36360   Copine family protein
Caenorhabditis elegans CELE_T28F3.1   Protein NRA-1, isoform B
Caenorhabditis elegans CELE_T12A7.1   Protein GEM-4
Dictyostelium discoideum DDB_G0284791   copine C
Dictyostelium discoideum DDB_G0274051   copine B
Dictyostelium discoideum DDB_G0272875   copine B
Dictyostelium discoideum DDB_G0293008   copine A
Dictyostelium discoideum DDB_G0291498   copine F
Dictyostelium discoideum DDB_G0290529   copine E
Dictyostelium discoideum DDB_G0267688   copine D
Echinococcus granulosus EgrG_000209400   copine 9
Echinococcus granulosus EgrG_000209350   copine 9
Echinococcus granulosus EgrG_000111400   copine 9
Entamoeba histolytica EHI_163260   copine, putative
Echinococcus multilocularis EmuJ_000111400   copine 9
Echinococcus multilocularis EmuJ_000209350   copine 9
Echinococcus multilocularis EmuJ_000209400   copine 9
Homo sapiens ENSG00000140848   copine II
Homo sapiens ENSG00000144550   copine family member IX
Homo sapiens ENSG00000085719   copine III
Homo sapiens ENSG00000139117   copine VIII
Homo sapiens ENSG00000214078   copine I
Homo sapiens ENSG00000124772   copine V
Leishmania braziliensis LbrM.28.1290   copine i-like protein
Leishmania donovani LdBPK_281300.1   copine i-like protein
Leishmania infantum LinJ.28.1300   copine i-like protein
Leishmania major LmjF.28.1190   copine i-like protein
Leishmania mexicana LmxM.28.1190   copine i-like protein
Loa Loa (eye worm) LOAG_02550   copine family protein
Mus musculus ENSMUSG00000028228   copine III
Mus musculus ENSMUSG00000024008   copine V
Mus musculus ENSMUSG00000074643   copine I
Mus musculus ENSMUSG00000052560   copine VIII
Mus musculus ENSMUSG00000034361   copine II
Mus musculus ENSMUSG00000030270   copine family member IX
Oryza sativa 4329499   Os02g0521300
Oryza sativa 9266651   Os05g0373300
Oryza sativa 9266743   Os08g0133201
Schistosoma japonicum Sjp_0074490   Copine-3, putative
Schistosoma mansoni Smp_060480   copine
Schmidtea mediterranea mk4.006117.00  
Schmidtea mediterranea mk4.002994.01  
Schmidtea mediterranea mk4.008789.02   Copine-1
Schmidtea mediterranea mk4.028260.00  
Schmidtea mediterranea mk4.014165.00  
Schmidtea mediterranea mk4.006117.03  
Schmidtea mediterranea mk4.006117.01  
Schmidtea mediterranea mk4.024437.00  
Schmidtea mediterranea mk4.020338.00  
Schmidtea mediterranea mk4.017307.00  
Schmidtea mediterranea mk4.008945.00  
Schmidtea mediterranea mk4.014165.01  
Trichomonas vaginalis TVAG_480960   copine, putative
Trichomonas vaginalis TVAG_219530   copine, putative
Trichomonas vaginalis TVAG_069450   copine, putative
Trichomonas vaginalis TVAG_037710   copine, putative
Trichomonas vaginalis TVAG_304980   copine, putative

Essentiality

TVAG_219530 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T28F3.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0109 0.4866 0.5
0.0072 0.2639 1
0.005 0.2612 0.5
0.0018 0.5 0.5
0.0125 0.3893 0.3893
0.0121 1 1
0.0071 0.2549 0.5
0.0057 0.3491 0.5
0.0107 0.5 0.5
0.0058 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_219530 (Trichomonas vaginalis), copine, putative
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