pI: 11.7654 |
Length (AA): 159 |
MW (Da): 17845 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126766)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G09690 | 60S ribosomal protein L21-1 |
Arabidopsis thaliana | AT1G57860 | translation protein SH3-like family protein |
Arabidopsis thaliana | AT1G57660 | 60S ribosomal protein L21-2 |
Arabidopsis thaliana | AT1G09590 | 60S ribosomal protein L21-1 |
Babesia bovis | BBOV_III010520 | ribosomal protein L21, putative |
Brugia malayi | Bm1_47445 | 60S ribosomal protein L21 |
Candida albicans | CaO19.840 | similar to C terminus of S. cerevisiae RPL21A (YBR191W) and RPL21B (YPL079W) genes for cytosolic ribosomal protein large subunit |
Candida albicans | CaO19.8460 | similar to C terminus of S. cerevisiae RPL21A (YBR191W) and RPL21B (YPL079W) genes for cytosolic ribosomal protein large subunit |
Caenorhabditis elegans | CELE_C14B9.7 | Protein RPL-21 |
Cryptosporidium hominis | Chro.60285 | ribosomal protein L21 |
Cryptosporidium parvum | cgd6_2460 | 60s ribosomal protein L21 |
Dictyostelium discoideum | DDB_G0279387 | S60 ribosomal protein L21 |
Drosophila melanogaster | Dmel_CG12775 | Ribosomal protein L21 |
Echinococcus granulosus | EgrG_000582200 | 60S ribosomal protein L21 |
Entamoeba histolytica | EHI_161180 | 60S ribosomal protein L21, putative |
Entamoeba histolytica | EHI_069110 | 60S ribosomal protein L21, putative |
Entamoeba histolytica | EHI_182920 | 60S ribosomal protein L21, putative |
Echinococcus multilocularis | EmuJ_000582200 | 60S ribosomal protein L21 |
Giardia lamblia | GL50803_15520 | Ribosomal protein L21 |
Homo sapiens | ENSG00000122026 | ribosomal protein L21 |
Leishmania braziliensis | LbrM.16.0480 | 60S ribosomal protein L21, putative |
Leishmania braziliensis | LbrM.20.3240 | 60S ribosomal protein L21, putative |
Leishmania donovani | LdBPK_343440.1 | 60S ribosomal protein L21, putative |
Leishmania infantum | LinJ.16.0470 | 60S ribosomal protein L21, putative |
Leishmania infantum | LinJ.34.3440 | 60S ribosomal protein L21, putative |
Leishmania major | LmjF.16.0460 | 60S ribosomal protein L21, putative |
Leishmania major | LmjF.34.3650 | 60S ribosomal protein L21, putative |
Leishmania mexicana | LmxM.16.0460 | 60S ribosomal protein L21, putative |
Leishmania mexicana | LmxM.33.3650 | 60S ribosomal protein L21, putative |
Loa Loa (eye worm) | LOAG_04391 | 60S ribosomal protein L21 |
Mus musculus | ENSMUSG00000041453 | ribosomal protein L21 |
Mus musculus | 636187 | predicted gene, 20764 |
Mus musculus | 102643293 | 60S ribosomal protein L21-like |
Mus musculus | 102641365 | 60S ribosomal protein L21-like |
Neospora caninum | NCLIV_062950 | 50S ribosomal protein L21e, related |
Oryza sativa | 9266412 | Os03g0141000 |
Oryza sativa | 4348839 | Os10g0465800 |
Plasmodium berghei | PBANKA_1018600 | 60S ribosomal protein L21, putative |
Plasmodium falciparum | PF3D7_1426000 | 60S ribosomal protein L21 |
Plasmodium knowlesi | PKNH_1332700 | 60S ribosomal protein L21, putative |
Plasmodium vivax | PVX_085225 | 60S ribosomal protein L21, putative |
Plasmodium yoelii | PY05142 | Ribosomal protein L21e, putative |
Saccharomyces cerevisiae | YPL079W | ribosomal 60S subunit protein L21B |
Saccharomyces cerevisiae | YBR191W | ribosomal 60S subunit protein L21A |
Schistosoma japonicum | Sjp_0069130 | ko:K02889 large subunit ribosomal protein L21e, putative |
Schistosoma mansoni | Smp_022560.2 | 60S ribosomal protein L21 |
Schistosoma mansoni | Smp_022560.1 | 60S ribosomal protein L21 |
Schmidtea mediterranea | mk4.000937.01 | 60S ribosomal protein L21 |
Trypanosoma brucei gambiense | Tbg972.11.660 | ribosomal protein L21E (60S), putative |
Trypanosoma brucei gambiense | Tbg972.4.930 | ribosomal protein L21E (60S), putative |
Trypanosoma brucei | Tb927.4.1100 | ribosomal protein L21E (60S), putative |
Trypanosoma brucei | Tb11.0880 | chrXI additional, unordered contigs |
Trypanosoma brucei | Tb927.11.680 | ribosomal protein L21E (60S), putative |
Trypanosoma brucei | Tb427.04.1100 | ribosomal protein L21E (60S), putative |
Trypanosoma congolense | TcIL3000.11.670 | ribosomal protein L21E (60S), putative |
Trypanosoma cruzi | TcCLB.507251.20 | ribosomal protein L21E (60S), putative |
Trypanosoma cruzi | TcCLB.506405.149 | ribosomal protein L21E (60S), putative |
Toxoplasma gondii | TGME49_245680 | ribosomal protein RPL21 |
Theileria parva | TP02_0089 | 60S ribosomal protein L21e, putative |
Trichomonas vaginalis | TVAG_277060 | 60S ribosomal protein L21, putative |
Trichomonas vaginalis | TVAG_141940 | 60S ribosomal protein L21, putative |
Trichomonas vaginalis | TVAG_119330 | 60S ribosomal protein L21, putative |
Trichomonas vaginalis | TVAG_446000 | 60S ribosomal protein L21, putative |
Trichomonas vaginalis | TVAG_231260 | 60S ribosomal protein L21, putative |
Trichomonas vaginalis | TVAG_231250 | 60S ribosomal protein L21, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.50.0005 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.50.0005 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.50.0005 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.50.0005 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.4.1100 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.1100 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.1100 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.1100 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C14B9.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C14B9.7 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C14B9.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C14B9.7 | Caenorhabditis elegans | sterile | wormbase |
TGME49_245680 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.